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Recombinant Human CDK4 protein, His-tagged

Cat.No. : CDK4-2208H
Product Overview : Recombinant Human CDK4 protein(P11802)(2-303aa), fused to N-terminal His tag, was expressed in Insect Cell.
  • Specification
  • Gene Information
  • Related Products
Source : Insect Cell
Species : Human
Tag : His
Form : If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Molecular Mass : 35.6 kDa
Protein length : 2-303aa
AA Sequence : ATSRYEPVAEIGVGAYGTVYKARDP HSGHFVALKSVRVPNGGGGGGGLPI STVREVALLRRLEAFEHPNVVRLMD VCATSRTDREIKVTLVFEHVDQDLR TYLDKAPPPGLPAETIKDLMRQFLR GLDFLHANCIVHRDLKPENILVTSG GTVKLADFGLARIYSYQMALTPVVV TLWYRAPEVLLQSTYATPVDMWSVG CIFAEMFRRKPLFCGNSEADQLGKI FDLIGLPPEDDWPRDVSLPRGAFPP RGPRPVQSVVPEMEESGAQLLLEML TFNPHKRISAFRALQHSYLHKDEGN PE
Purity : Greater than 90% as determined by SDS-PAGE.
Storage : Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Gene Name : CDK4 cyclin-dependent kinase 4 [ Homo sapiens ]
Official Symbol : CDK4
Synonyms : CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458;
Gene ID : 1019
mRNA Refseq : NM_000075
Protein Refseq : NP_000066
MIM : 123829
UniProt ID : P11802

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential challenges in targeting CDK4 for cancer therapy? 11/24/2022

Resistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.

Can CDK4 be targeted for cancer therapy? 06/16/2022

Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.

How is CDK4 clinically relevant? 06/30/2020

CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.

Which cancers are commonly associated with CDK4 overactivity? 06/19/2020

CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.

How does CDK4 relate to cell senescence? 05/31/2016

CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.

Customer Reviews (3)

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Reviews
02/18/2023

    Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

    02/16/2020

      They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.

      05/29/2018

        The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

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