CFL2 Protein, cofilin 2 (muscle)

CFL2

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CFL2

Official Full Name cofilin 2 (muscle)
Background This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Synonyms CFL2; cofilin 2 (muscle); cofilin-2; cofilin, muscle isoform; NEM7
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cfl2-881M Recombinant Mouse Cfl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CFL2-11143H Recombinant Human CFL2, GST-tagged E.coli GST
    Human CFL2-1174H Recombinant Human CFL2 Protein, GST-Tagged Wheat Germ GST
    Human CFL2-26779TH Recombinant Human CFL2 Wheat Germ N/A
    Human CFL2-26843TH Recombinant Human CFL2, His-tagged E.coli His
    Human CFL2-6905H Recombinant Human CFL2, His tagged E.coli His
    Human CFL2-7554HCL Recombinant Human CFL2 293 Cell Lysate HEK293 N/A
    Mouse CFL2-3351M Recombinant Mouse CFL2 Protein Mammalian Cell His
    Rhesus Macaque CFL2-829R Recombinant Rhesus monkey CFL2 Protein, His-tagged Mammalian Cell His
    Chicken CFL2-1224C Recombinant Chicken CFL2 Mammalian Cell His
    Zebrafish CFL2-11722Z Recombinant Zebrafish CFL2 Mammalian Cell His

    CFL2 involved in several pathways and played different roles in them. We selected most pathways CFL2 participated on our site, such as Axon guidance, Caspase cascade in apoptosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance RHOD; NFATC2; COL6A3; PTPRA; SCN3A; RASGRP1; LIMK2; SEMA3AA; MAPK1; MET
    Caspase cascade in apoptosis ACTA1; DIABLO; CFL2; NUMA1; CASP4; PARP1; LMNB1; DFFA; GAS2; CRADD
    Fc gamma R-mediated phagocytosis PRKCA; FCGR2B; RAF1; CFL2; VAV3; AKT1; FCGR1A; RAC1; cgr2b; VAV1
    G13 Signaling Pathway CFL2; CIT; TNK2; ARHGEF1A; MYBPH; RHPN2; RTKN; DIAPH1; SH3RF1; MYL1
    Leptin signaling pathway CFL2; KHDRBS1; IL1RN
    Pertussis IRAK1; CALM2; RHOA; C1RA; TICAM2; MAPK8; IL1A; Itgam&Itgb2; CALML5; ITGA5
    Regulation of Actin Cytoskeleton GNG12A; PIP5K1A; RHOAC; WASLB; MRAS; ITGA2; ENAH; MYL5; RHOAB; PTK2AB
    Regulation of Microtubule Cytoskeleton CFL2; MARK1; MARK2; TPPP; TESK2; MAP1B; DPYSL2

    CFL2 has several biochemical functions, for example, actin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFL2 itself. We selected most functions CFL2 had, and list some proteins which have the same functions with CFL2. You can find most of the proteins on our site.

    Function Related Protein
    actin binding MYHZ1.1; WASF3; FMN2; TPM1; KIF18A; TWF2B; MYH1; SPATA32; MPRIP; ANLN
    protein binding EEF1E1; E2F4; PPP4C; STX16; CBLB; PRX; ZNF410; ATP6V1G1; KLRB1F; KIAA0368

    CFL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFL2.

    ACTB; ACTG1; CSRP3; MAP3K3; CFL1; STK11; MYO1C; FLNA; MYH9; IQGAP1; CAPZA2; Tpm1; PPP1CB; GRB2; DBN1

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