cntfr
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  • Official Full Name
  • ciliary neurotrophic factor receptor
  • Background
  • This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component;of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival,;differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the;transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal;transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as;well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms
  • CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; MGC1774
Cat.#:CNTFR-361HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CNTFR Protein, His-tagged
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Cat.#:CNTFR-1607HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CNTFR Protein, GST-tagged
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Cat.#:CNTFR-3287HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CNTFR Protein, MYC/DDK-tagged
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Cat.#:CNTFR-381HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CNTFR Protein, His-tagged
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Cat.#:CNTFR-178HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CNTFR
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Cat.#:CNTFR-3334HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CNTFR, His tagged
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Cat.#:CNTFR-3683MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CNTFR Protein
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Cat.#:CNTFR-1501RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CNTFR Protein
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Cat.#:Cntfr-4084RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Cntfr, His tagged
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Cat.#:CNTFR-949RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CNTFR Protein, His-tagged
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Cat.#:CNTFR-6585CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CNTFR
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Cat.#:CNTFR-5666ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CNTFR
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Cat.#:CNTFR-1596HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Ciliary Neurotrophic Factor Receptor
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Cat.#:CNTFR-687HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CNTFR cell lysate
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Cat.#:CNTFR-598RCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat CNTFR cell lysate
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Involved Pathway

CNTFR involved in several pathways and played different roles in them. We selected most pathways CNTFR participated on our site, such as Adipogenesis, Cytokine-cytokine receptor interaction, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adipogenesis
CEBPA; STIL; CISD1; BMP3; NDN; MBNL1; AGPAT2; SPOCK1; GATA2A; CNTFR
Cytokine-cytokine receptor interaction
CXCL3; TNFB; IL6; XCL1; IL20; TGFB1A; IFNA13; CCL11; IFNA4; IL2RGA
Delta-Notch Signaling Pathway
YY1; CNTFR; HEY2; WDR12; JAG1; CNTN1B; SMAD3B; ADAM10A; YY1A; TCF3B
Jak-STAT signaling pathway
CCND2A; IL12B; IL21R.1; IL11RA; IL12A; IFNK; IL27RA; IL4R; AKT2L; HRASB

Protein Function

CNTFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity, cytokine binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTFR itself. We selected most functions CNTFR had, and list some proteins which have the same functions with CNTFR. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ciliary neurotrophic factor receptor activity
Related Protein CNTFR; LIFR; IL6R; Il6ra
Function cytokine binding
Related Protein KITB; CXCR4; ELANE; CHRD; NRP2; CRLF1; IL17F; NOG; NRP1; CNTFR
Function receptor binding
Related Protein CCL17; ADIPOQ; MYO1C; SCP2; HSPA1B; PVRL2; SMARCD3; TNFSF4; CCL2; Ifnl2

Interacting Protein

CNTFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTFR here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTFR.
ABL1; FYN; NCK1; CRK; GRB2; PLSCR1; APPBP2; CRAMP1L; KRTAP4-12

CNTFR Related Articles

Lee, N; Spearry, RP; et al. Muscle ciliary neurotrophic factor receptor promotes axonal regeneration and functional recovery following peripheral nerve lesion. JOURNAL OF COMPARATIVE NEUROLOGY 521:2947-2965(2013).
Lu, J; Ksendzovsky, A; et al. CNTF receptor subunit alpha as a marker for glioma tumor-initiating cells and tumor grade. JOURNAL OF NEUROSURGERY 117:1022-1031(2012).

CNTFR Related Gene Family

IL