Recombinant Human CNTFR Protein, His-tagged

• Cat.No.: CNTFR-184H
• Product Overview: Recombinant human CNTFR protein with His tag was expressed in HEK293.

Specification

• Description: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 36.9 kDa
• Protein length: 372
• AA Sequence: MAAPVPWACCAVLAAAAAVVYAQRH SPQEAPHVQYERLGSDVTLPCGTAN WDAAVTWRVNGTDLAPDLLNGSQLV LHGLELGHSGLYACFHRDSWHLRHQ VLLHVGLPPREPVLSCRSNTYPKGF YCSWHLPTPTYIPNTFNVTVLHGSK IMVCEKDPALKNRCHIRYMHLFSTI KYKVSISVSNALGHNATAITFDEFT IVKPDPPENVVARPVPSNPRRLEVT WQTPSTWPDPESFPLKFFLRYRPLI LDQWQHVELSDGTAHTITDAYAGKE YIIQVAAKDNEIGTWSDWSVAAHAT PWTEEPRHLTTEAQAAETTTSTTSS LAPPPTTKICDPGELGSGGGPSAPF LVSVPITLALAAAAATASSLLI
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: CNTFR ciliary neurotrophic factor receptor [ Homo sapiens (human) ]
• Official Symbol: CNTFR
• Synonyms: CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; MGC1774
• Gene ID: 1271
• mRNA Refseq: NM_001207011
• Protein Refseq: NP_001193940
• MIM: 118946
• UniProt ID: P26992