Recombinant Human CNTFR Protein (23-342aa), C-His-tagged

• Cat.No.: CNTFR-12H
• Product Overview: Recombinant human CNTFR (23-342aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Specification

• Description: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
• Source: Baculovirus
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 36.9 kDa (329aa)
• Protein length: 23-342
• AA Sequence: ADPQRHSPQEAPHVQYERLGSDVTL PCGTANWDAAVTWRVNGTDLAPDLL NGSQLVLHGLELGHSGLYACFHRDS WHLRHQVLLHVGLPPREPVLSCRSN TYPKGFYCSWHLPTPTYIPNTFNVT VLHGSKIMVCEKDPALKNRCHIRYM HLFSTIKYKVSISVSNALGHNATAI TFDEFTIVKPDPPENVVARPVPSNP RRLEVTWQTPSTWPDPESFPLKFFL RYRPLILDQWQHVELSDGTAHTITD AYAGKEYIIQVAAKDNEIGTWSDWS VAAHATPWTEEPRHLTTEAQAAETT TSTTSSLAPPPTTKICDPGELGSHH HHHH
• Endotoxin: < 1 EU/μg of protein (determined by LAL method)
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/mL (determined by absorbance at 280nm)
• Storage Buffer: Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Gene Information

• Gene Name: CNTFR ciliary neurotrophic factor receptor [ Homo sapiens (human) ]
• Official Symbol: CNTFR
• Synonyms: CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR-alpha
• Gene ID: 1271
• mRNA Refseq: NM_001842
• Protein Refseq: NP_001833
• MIM: 118946
• UniProt ID: P26992