Recombinant Human CNTFR Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CNTFR-5041H
• Product Overview: CNTFR MS Standard C13 and N15-labeled recombinant protein (NP_671693) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 40.6 kDa
• AA Sequence: MAAPVPWACCAVLAAAAAVVYAQRH SPQEAPHVQYERLGSDVTLPCGTAN WDAAVTWRVNGTDLAPDLLNGSQLV LHGLELGHSGLYACFHRDSWHLRHQ VLLHVGLPPREPVLSCRSNTYPKGF YCSWHLPTPTYIPNTFNVTVLHGSK IMVCEKDPALKNRCHIRYMHLFSTI KYKVSISVSNALGHNATAITFDEFT IVKPDPPENVVARPVPSNPRRLEVT WQTPSTWPDPESFPLKFFLRYRPLI LDQWQHVELSDGTAHTITDAYAGKE YIIQVAAKDNEIGTWSDWSVAAHAT PWTEEPRHLTTEAQAAETTTSTTSS LAPPPTTKICDPGELGSGGGPSAPF LVSVPITLALAAAAATASSLLITRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CNTFR ciliary neurotrophic factor receptor [ Homo sapiens (human) ]
• Official Symbol: CNTFR
• Synonyms: CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; MGC1774
• Gene ID: 1271
• mRNA Refseq: NM_147164
• Protein Refseq: NP_671693
• MIM: 118946
• UniProt ID: P26992