cst3
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  • Official Full Name
  • cystatin C
  • Background
  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013]
  • Synonyms
  • CST3; cystatin C; ARMD11; cystatin-C; cystatin 3; cystatin-3; gamma-trace; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide
Cat.#:CST3-2025HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CST3 Protein, GST-tagged
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Cat.#:CST3-3355HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST3 Protein, MYC/DDK-tagged
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Cat.#:CST3-11643HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CST3, GST-tagged
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Cat.#:CST3-1914HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Cystatin C
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Cat.#:CST3-222HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST3 Protein
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Cat.#:CST3-2713HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Cystatin C
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Cat.#:CST3-3172HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST3, His tagged
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Cat.#:CST3-3666HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CST3, His-tagged
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Cat.#:CST3-3667HTag:N/A
Source (Host):NativeSpecies:Human
Product nameHuman Cystatin C 1r4c
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Cat.#:CST3-50HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CST3 protein, His-tagged
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Cat.#:CST3-692HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CST3
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Cat.#:Cst3-2205MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cst3, His tagged
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Cat.#:Cst3-246MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cystatin C, His-tagged
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Cat.#:Cst3-3669MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cst3, His-tagged
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Cat.#:CST3-373MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse CST3 Protein, His-tagged
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Cat.#:CST3-1645RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CST3 Protein
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Cat.#:Cst3-253RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cystatin C, His-tagged
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Cat.#:Cst3-33RTag:His
Source (Host):Insect cellsSpecies:Rat
Product nameRecombinant Rat Cst3 Protein, His-tagged
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Cat.#:Cst3-3670RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cst3, His-tagged
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Cat.#:Cst3-4094RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cst3, His tagged
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Cat.#:CST3-1068RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CST3 Protein, His-tagged
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Cat.#:CST3-7049CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CST3
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Cat.#:CST3-7898CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CST3 protein, His-tagged
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Cat.#:CST3-3366ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CST3
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Cat.#:CST3-7897CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CST3 protein, His-tagged
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Cat.#:CST3-7899PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CST3 protein, His & GST-tagged
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Cat.#:CST3-376HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cystatin C
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Cat.#:CST3-26152THTag:
Source (Host):Species:Human
Product nameNative Human CST3
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Cat.#:CST3-4309HTag:
Source (Host):HumanSpecies:Human
Product nameNative Human CST3 Protein
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Cat.#:CST3-8100HTag:N/A
Source (Host):Human Urine - chronic protein renal tubular proteinuriaSpecies:Human
Product nameNative Human Cystatin C (Cystatin 3)
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Cat.#:CST3-2991HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CST3 cell lysate
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Cat.#:CST3-2470MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CST3 cell lysate
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Cat.#:CST3-1938RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CST3 cell lysate
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Cat.#:CST3-11HTag:
Source (Host):Species:Human
Product nameHuman Cystatin C Reference Standard
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Cat.#:CST3-6HTag:
Source (Host):Species:Human
Product nameCystatin C in Human Serum Reference Standard
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Cat.#:Cst3-35MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Cystatin C Reference Standard
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Cat.#:Cst3-76RTag:N/A
Source (Host):Species:Rat
Product nameRat Cystatin C Reference Standard
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Involved Pathway

CST3 involved in several pathways and played different roles in them. We selected most pathways CST3 participated on our site, such as Amyloid formation, Integrated Pancreatic Cancer Pathway, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyloid formation
HIST3H2BB; HIST4H4; LTF; CALCA; TGFBI; SEMG1; NAT8; ODAM; SAA1; NAT8B
Integrated Pancreatic Cancer Pathway
GPRC5A; FKBP1B; CST3; CASP12; PPP1R13L; MST1; MAPK4; AGA; TFF1; NOXA1
Metabolism of proteins
MUCL1; MUC13; ADAMTSL4; SEC23IP; CNIH3; IGF2B; MPDU1A; TOMM70A; EXOC6; MPDU1
Salivary secretion
ITPR3; CALML5; LYZ1; DMBT1; CALM2; PRKCB; PRKACA; LYZ2; NOS1; PRB1

Protein Function

CST3 has several biochemical functions, for example, beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST3 itself. We selected most functions CST3 had, and list some proteins which have the same functions with CST3. You can find most of the proteins on our site.
Function
Related Protein
Function beta-amyloid binding
Related Protein APBB3; PION; CHRNA7; MAPK8IP2; APOA1; LDLRAP1; NGFR; APOE; APOEB; CLSTN1
Function cysteine-type endopeptidase inhibitor activity
Related Protein STFA2; NLRC4; BIRC5B; CST14B.1; CST2; CST5; CST1; CST9L; AHSG; FETUB
Function endopeptidase inhibitor activity
Related Protein WFDC2; STFA1; SERPINA1D; SERPINA1A; CST3; PZP; CAST; C3; PROS1; Serpina1b
Function identical protein binding
Related Protein VPS41; DIAP1; SIRT1; GLUD1; MSANTD3; DIAPH1; TRIM8; CLDN2; ALCAMA; EED
Function protease binding
Related Protein TNFRSF10A; TTN; INSL3; TP53; STIM1; TNF; Serpina1b; TNFAIP3; PEO1; CNTNAP2
Function protein binding
Related Protein APOBEC1; CCDC11; MAP2; CENPP; NCL; LAPTM5; VEZT; ELN; CDC7; LGALS13

Interacting Protein

CST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST3.
ATXN1; proS; gmhB; ALB

CST3 Related Articles

Wuttke, M; Schaefer, F; et al. Genome-Wide Association Studies in Nephrology: Using Known Associations for Data Checks. AMERICAN JOURNAL OF KIDNEY DISEASES 65:217-222(2015).
Lamontagne, M; Timens, W; et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. THORAX 69:997-+(2014).