ctsh
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  • Official Full Name
  • cathepsin H
  • Background
  • The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
  • Synonyms
  • CTSH; cathepsin H; CPSB; pro-cathepsin H; ACC 4; ACC 5; aleurain; cathepsin B3; cathepsin BA; N-benzoylarginine-beta-naphthylamide hydrolase; ACC-4; ACC-5; minichain; MGC1519; DKFZp686B24257
Cat.#:CTSH-2108HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSH Protein, GST-tagged
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Cat.#:CTSH-3371HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSH Protein, MYC/DDK-tagged
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Cat.#:CTSH-1650HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameRecombinant Human Cathepsin H
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Cat.#:CTSH-11688HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSH, GST-tagged
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Cat.#:CTSH-3042HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cathepsin H, T7-tagged
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Cat.#:CTSH-478HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human CTSH, His-tagged
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Cat.#:CTSH-8180HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSH protein, His & T7-tagged
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Cat.#:Ctsh-481MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctsh, His-tagged
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Cat.#:Ctsh-8181MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsh protein, His & T7-tagged
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Cat.#:CTSH-1665RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTSH Protein
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Cat.#:CTSH-11964ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTSH
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Cat.#:CTSH-190HTag:
Source (Host):Species:Human
Product nameNative Human Cathepsin H
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Cat.#:CTSH-27404THTag:
Source (Host):Species:Human
Product nameNative Human CTSH
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Cat.#:CTSH-360HTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human Eosinophil Peroxidase
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Cat.#:CTSH-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CTSH cell lysate
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Cat.#:Kit-2153Tag:
Source (Host):Species:
Product nameCathepsin H Inhibitor Screening Kit
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Involved Pathway

CTSH involved in several pathways and played different roles in them. We selected most pathways CTSH participated on our site, such as Adaptive Immune System, Immune System, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LAIR1; SPSB4; LRSAM1; KIF2A; AKT3; NA; RNF34; DCTN3; LILRA3; SH3RF1
Immune System
IGHM; PAG1; PANX1; DZIP3; MGC174152; DTX3L; GBP5; TRIM68; DCTN6; TRIM39
Lysosome
ACP2; CLN5; ATP6V0D2; HGSNAT; GUSB; LAPTM5; LAPTM4B; GALC; ATP6V0A1B; GALNS
MHC class II antigen presentation
CTSO; KIFAP3; CTS7; KIF3C; KIF22; IFI30; DYNC1I1; MGC174155; RACGAP1; KIF3B
Metabolism of proteins
DPAGT1; FKBP14; TBCD; LMAN2; NAPB; CBX4; EEF1G; ALG10B; SENP5; PHC3
Surfactant metabolism
DMBT1; SLC34A2A; SFTPBB; SFTPC; ZDHHC2; CCDC59; CTSH; LMCD1; GPR116; CKAP4

Protein Function

CTSH has several biochemical functions, for example, HLA-A specific activating MHC class I receptor activity, aminopeptidase activity, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSH itself. We selected most functions CTSH had, and list some proteins which have the same functions with CTSH. You can find most of the proteins on our site.
Function
Related Protein
Function HLA-A specific activating MHC class I receptor activity
Related Protein CTSH
Function aminopeptidase activity
Related Protein METAP1D; XPNPEP1; ERAP2; METAP2A; PHEX; NPEPPS; LAP3; TRHDE; DNPEP; CTSL2
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein MAPK9; APAF1; PYCARD; CTSC; NLRP1; BCL2L13; NLRP12; CASP1; NOD1; RPS27L
Function cysteine-type endopeptidase activity
Related Protein CTSSB.2; CTSW; CTSS; Casp3; CASP6L1; CASP6L2; Ctsl; USP38; CASP10; MALT1A
Function cysteine-type peptidase activity
Related Protein CAPN2B; OTUD7A; USP17L1P; CASP8L1; CAPN3A; ESPL1; SENP7; BLMH; ALG13; USPL1
Function endopeptidase activity
Related Protein PSMB8F; PSMB9; ATG4B; APH1C; CD46; NCSTN; KLK1B9; ECE1; PSMA3; PSMB10
Function peptidase activity
Related Protein CLCA5; METAP2A; F2RL1.2; KLK1B16; ADAMTS12; NAALADL1; SPG7; CTS7; PM20D1; ELA2
Function protein binding
Related Protein IRF2BP1; ZBTB7A; CFH; PVRL4; LUZP4; DEDD; CDC42EP1; GTF2B; KLRG1; ZNF227
Function serine-type endopeptidase activity
Related Protein PRSS27; PROCA; PRSS23; AZU1; TYSND1; PRSS42; PRSS37; PRSS52; KLK15; ELANE
Function thyroid hormone binding
Related Protein CTSH; ALDH1A3; THRA; CRYM; THRB

Interacting Protein

CTSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSH here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSH.
VCAM1

CTSH Related Articles

Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).
Kiyamova, R; Garifulin, O; et al. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers. BIOMARKERS 17:362-371(2012).