CTSH Protein, cathepsin H

CTSH

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CTSH

Official Full Name cathepsin H
Background The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
Synonyms CTSH; cathepsin H; CPSB; pro-cathepsin H; ACC 4; ACC 5; aleurain; cathepsin B3; cathepsin BA; N-benzoylarginine-beta-naphthylamide hydrolase; ACC-4; ACC-5; minichain; MGC1519; DKFZp686B24257
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human Liver
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTSH-11688H Recombinant Human CTSH, GST-tagged E.coli GST
    Human CTSH-1650H Recombinant Human Cathepsin H Human liver N/A
    Human CTSH-190H Native Human Cathepsin H Human Liver N/A
    Human CTSH-2108H Recombinant Human CTSH Protein, GST-tagged Wheat Germ GST
    Human CTSH-27404TH Native Human CTSH N/A
    Human CTSH-3042H Recombinant Human Cathepsin H, T7-tagged E.coli T7
    Human CTSH-3371H Recombinant Human CTSH Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CTSH-360H Native Human Eosinophil Peroxidase Human Liver N/A
    Human CTSH-478H Recombinant Human CTSH, His-tagged CHO His
    Human CTSH-8180H Recombinant Human CTSH protein, His & T7-tagged E.coli His/T7
    Mouse CTSH-001MCL Recombinant Mouse CTSH cell lysate Human Cell N/A
    Mouse Ctsh-481M Recombinant Mouse Ctsh, His-tagged Human Cell His
    Mouse Ctsh-8181M Recombinant Mouse Ctsh protein, His & T7-tagged E.coli His/T7
    Rat CTSH-1665R Recombinant Rat CTSH Protein Mammalian Cell His
    Zebrafish CTSH-11964Z Recombinant Zebrafish CTSH Mammalian Cell His
    Kit-2153 Cathepsin H Inhibitor Screening Kit N/A

    CTSH involved in several pathways and played different roles in them. We selected most pathways CTSH participated on our site, such as Adaptive Immune System, Immune System, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System SH3RF1; KIF3C; UBE2E3; CD300LH; HCST; DCTN6; UBA5; CD300LF; LTN1; RNF25
    Immune System IFIT2; KIF22; BTR18; GBP6; TXNIPB; CD180; IFI6; KLC3; UBR1; GRAP2A
    Lysosome TCIRG1; Abca2; LAPTM4B; ATP6V0A4; ATP6V0A1; NAGLU; SLC11A1; ASAH1; ATP6V1H; AGA
    MHC class II antigen presentation KLC3; CTSO; DYNC1I1; CTSC; CTSE; MGC174155; DYNC1LI2; RACGAP1; MGC174152; ACTR1B
    Metabolism of proteins CALCA; PAM16; WDR85; MUC12; PROZ; COX17; FBXL5; MUC13; DPH3; PREB
    Surfactant metabolism SFTPBB; DMBT1; ZDHHC2; SLC34A2A; CTSH; CKAP4; SFTPC; LMCD1; GPR116; GATA6

    CTSH has several biochemical functions, for example, HLA-A specific activating MHC class I receptor activity, aminopeptidase activity, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSH itself. We selected most functions CTSH had, and list some proteins which have the same functions with CTSH. You can find most of the proteins on our site.

    Function Related Protein
    HLA-A specific activating MHC class I receptor activity CTSH
    aminopeptidase activity ERAP1; XPNPEP2; CTSH; DNPEP; METAP2A; LAP3; ERAP2; ANPEP; NPEPPS; RNPEP
    cysteine-type endopeptidase activator activity involved in apoptotic process NLRP12; PYCARD; NOD1; BAD; BCL2L13; MAPK9; APAF1; RPS27L; CTSH; GNB2L1
    cysteine-type endopeptidase activity USP50; USP31; CTSLA; CTSH; CTSSB.1; USP2; USP17L2; ATG4D; ATG4A; USP9
    cysteine-type peptidase activity CTSJ; PGPEP1; OTUD6B; OTUD7B; CASPBL; FAM49BA; CTSLL; CASP6; USP2A; CTSSB.1
    endopeptidase activity PSMA5; TPP2; TPP1; KLK1B3; PSMA6A; KLK1B24; HTRA3; ACE2; PARL; TMEM59
    peptidase activity CTSL1B; CAPN8; USP27X; C3orf37; MMP30; USP2A; GZMF; ESPL1; METAP2; HTRA1A
    protein binding RAD51B; HDGFRP2; MAPK11; MAGEA2B; PDIA2; PSMB10; PAM16; SSX1; AMBP; CTCF
    serine-type endopeptidase activity RHBDD2; PRSS50; CMA1; PREPL; GM5077; PRSS33; KLK7; CELA3A; PROCA; TMPRSS4
    thyroid hormone binding CRYM; ALDH1A3; THRA; CTSH; THRB

    CTSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSH here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSH.

    VCAM1

    Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).
    Kiyamova, R; Garifulin, O; et al. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers. BIOMARKERS 17:362-371(2012).

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