CTSK
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Official Full Name
cathepsin K
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Overview
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] -
Synonyms
CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cattle
- Chicken
- Cynomolgus monkey
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Rhesus monkey (Simian)
- Zebrafish
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CTSK Related Research Area
CTSK involved in several pathways and played different roles in them. We selected most pathways CTSK participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of Matrix Metalloproteinases | MGC174155;TPSAB1;MGC174857;MMP10;MMP24;MMP11;MMP15;MMP13;FURINB |
Adaptive Immune System | CTSD;LAIR2;IGLC2;TREM1;KIF3A;DNM1;AGO1;UBA5;CTSO |
Collagen degradation | LOC100686744;CTSD;ADAM10;MMP8;TLDC2;MMP20;CTSLL;MGC174155;COL9A1 |
Degradation of the extracellular matrix | MMP10;ADAM9;ADAMTS5;CAPNS1;FAM49BA;CTSG;CTSD;COL17A1;TLL1 |
Extracellular matrix organization | ADAMTS8;LAMC3;NID1;LEPREL1;COL8A1;MFAP4;COL23A1;COL15A1B;MMP17 |
Immune System | RBCK1;DYNC1LI2;KIF22;AP1S3A;CASP2;DEFB119;RAP1GAP2;AMICA1;UBE2F |
Innate Immune System | BFB;MB21D1;DDX41;IRF2;TXNIPB;CFD;TREM1;DEFB4B;PELI2 |
Lysosome | HEXA;AP4B1;CTSSA;GNS;AP1M3;NAGLU;CD68;DNASE2;SLC11A1 |
CTSK has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSK itself. We selected most functions CTSK had, and list some proteins which have the same functions with CTSK. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | ADAM9;MMP13;DCN;RELL2;PDGFB;SERPINH2;PCOLCE2;PODN;PDGFA |
cysteine-type endopeptidase activity | USP17L2;CASP2;USP49;USP22;CTSBA;USP47;CTSL2;CASP6L1;USP42 |
cysteine-type peptidase activity | CTSL1B;CTSB;USP27X;USP17L1P;DESI1;CTSM;USP43A;BLMH;CTSSB.2 |
fibronectin binding | SFRP2;HSD17B12;CCDC80;IGFBP3;VEGFA;IGFBP5;IGFBP5A;MFAP2;CTGF |
protein binding | ALOX12B;CDC20B;SH2B2;AKTIP;SSTR2;SF1;RBMY1F;RNF5;AASDHPPT |
proteoglycan binding | CECR1A;CTSK;THBS1;CTSL1;FCN2;UBE4A;CTSS;CTSB;COL5A1 |
CTSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSK.
srp-6; FGFR3; mexB
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, CTSK inhibitors are being investigated for their potential in preventing bone loss associated with periodontal diseases.
CTSK has been linked to vascular calcification in atherosclerosis, and inhibiting its activity may have potential as a therapeutic strategy for cardiovascular diseases.
CTSK inhibitors could potentially be used to limit bone destruction in cancer patients with bone metastasis, improving their quality of life.
CTSK inhibitors are being explored for potential therapeutic applications in conditions like rheumatoid arthritis and certain cancers due to their involvement in tissue remodeling.
While CTSK is not currently used as a diagnostic marker, its levels and activity could potentially be explored for diagnostic purposes in the future.
Customer Reviews (3)
Write a reviewThis guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.
They have a deep understanding of the CTSK protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
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