ctsk
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  • Official Full Name
  • cathepsin K
  • Background
  • The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2;
Cat.#:CTSK-439RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat CTSK Protein (115-329 aa), His-tagged
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Cat.#:CTSK-440RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CTSK Protein (115-329 aa), His-tagged
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Cat.#:CTSK-2111HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSK Protein, GST-tagged
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Cat.#:CTSK-9392HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSK Protein
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Cat.#:CTSK-1659HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cathepsin K
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Cat.#:CTSK-22HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Procathepsin K Protein
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Cat.#:CTSK-329HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSK Protein, His-tagged
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Cat.#:CTSK-330HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSK Protein, His-tagged
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Cat.#:CTSK-680HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Procathepsin K
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Cat.#:CTSK-690HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CTSK
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Cat.#:Ctsk-331MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsk Protein, His/GST-tagged
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Cat.#:CTSK-4055MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTSK Protein
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Cat.#:CTSK-1667RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTSK Protein
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Cat.#:CTSK-1089RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTSK Protein, His-tagged
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Cat.#:CTSK-328DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CTSK Protein, His/GST-tagged
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Cat.#:CTSK-6530CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTSK
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Cat.#:CTSK-2521ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTSK
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Cat.#:CTSK-327CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CTSK Protein, His-tagged
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Cat.#:CTSK-332PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CTSK Protein, His/GST-tagged
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Cat.#:CTSK-333RTag:His
Source (Host):E. coliSpecies:Rhesus monkey (Simian)
Product nameRecombinant Rhesus monkey CTSK Protein, His-tagged
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Cat.#:CTSK-7192HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTSK 293 Cell Lysate
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Cat.#:Kit-2352Tag:
Source (Host):Species:
Product nameCathepsin K Inhibitor Screening Kit (Fluorometric)
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Involved Pathway

CTSK involved in several pathways and played different roles in them. We selected most pathways CTSK participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
CTSG; MMP11; MMP13; CTRB1; TPSAB1; ELANE; TIMP2; LOC100686744; CMA1; MMP24
Adaptive Immune System
LRSAM1; ASB14; SPTBN2; CD200R3; KIF4A; RAP1GAP2; FBXO44; CSK; AP2A1; CYBB
Collagen degradation
MMP12; COL15A1B; COL9A1; MMP20; COL23A1; MMP15; ADAM9; TLDC2; MMP11; LOC100686744
Degradation of the extracellular matrix
BMP1; TLL2; MGC174155; MMP24; TPSAB1; TLDC2; ADAMTS1; CTSL1; MGC174857; CTSB
Extracellular matrix organization
MGC174152; PCOLCE2; CEACAM6; COL17A1; MMP12; TIMP2B; CEACAM1; MFAP3; MMP8; CTSK
Immune System
SIGLEC12; ASB17; PVRL2L; LTN1; CRCP; ASB14; CD200R2; SAMHD1; TXNIPA; PELI2
Innate Immune System
BTR06; ART1; PELI1; ACTR2B; PPAPDC1A; IRAK3; DEFB4A; BTR02; POLR3G; DEFB125
Lysosome
AP3S1; CTSH; MFSD8; NAGA; CTSM; ACP5; CTSE; AP3D1; ACP5B; AP1S2

Protein Function

CTSK has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSK itself. We selected most functions CTSK had, and list some proteins which have the same functions with CTSK. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein LUM; LRRC15; CD44; ACHE; Pdgfa&Pdgfb; ITGA3; LACRT; CTSS; CTSK; CCBE1
Function cysteine-type endopeptidase activity
Related Protein TINAG; USP9X; USP6; CASP10; BLMH; PDIA3; USP9; FAM49BA; USP34; USP4
Function cysteine-type peptidase activity
Related Protein CAPN1A; DUB1; FAM49BA; CTSJ; USP9; Ctsl; CTSBA; CTSZ; PIGK; CAPN2B
Function fibronectin binding
Related Protein SFRP2; ITGAV; LPA; ITGB1A; ITGB3; FBLN1; MYOC; LRRC15; ITGA4; LACRT
Function protein binding
Related Protein SPARC; CEP85; TRIM13; CUBN; PRH2; ZNF180; PRR16; RCN1; DALRD3; STK36
Function proteoglycan binding
Related Protein CTSS; UBE4A; CECR1A; COL5A1; THBS1; SLIT2; CTSK; CECR1; CTSB; CTSL1

Interacting Protein

CTSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSK.
srp-6; FGFR3; mexB