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CTSK

  • Official Full Name

    cathepsin K

  • Overview

    The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
  • Synonyms

    CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cattle
  • Chicken
  • Cynomolgus monkey
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey (Simian)
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSK-22H Active Recombinant Human Procathepsin K Protein Insect Cell N/A
Human CTSK-680H Recombinant Human Procathepsin K E.coli N/A
Human CTSK-329H Recombinant Human CTSK Protein, His-tagged E.coli His Ala115~Met329
Human CTSK-1659H Recombinant Human Cathepsin K E.coli N/A
Human CTSK-690H Recombinant Human CTSK Insect Cell N/A
Human CTSK-330H Recombinant Human CTSK Protein, His-tagged E.coli His Leu54~Ala317
Human CTSK-2111H Recombinant Human CTSK Protein, GST-tagged Wheat Germ GST
Human CTSK-7192HCL Recombinant Human CTSK 293 Cell Lysate HEK293 N/A
Human CTSK-1890H Recombinant Human CTSK Protein (Ala115-Met329), His tagged E.coli His Ala115-Met329
Human CTSK-5386H Recombinant Human CTSK protein, His-tagged Yeast His 115-329aa
Human CTSK-2354HF Recombinant Full Length Human CTSK Protein, GST-tagged In Vitro Cell Free System GST 329 amino acids
Human CTSK-9392H Active Recombinant Human CTSK Protein E. coli N/A
Mouse Ctsk-331M Recombinant Mouse Ctsk Protein, His/GST-tagged E.coli His/GST Gly113~Asn316
Mouse CTSK-4055M Recombinant Mouse CTSK Protein Mammalian Cell His
Mouse Ctsk-2761M Recombinant Mouse Ctsk protein, His-tagged E.coli His 115-329aa
Mouse CTSK-2069M-B Recombinant Mouse CTSK Protein Pre-coupled Magnetic Beads HEK293
Mouse CTSK-2069M Recombinant Mouse CTSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTSK-1667R Recombinant Rat CTSK Protein Mammalian Cell His
Rat CTSK-439R Recombinant Rat CTSK Protein (115-329 aa), His-tagged E.coli His 115-329 aa
Rat Ctsk-441R Recombinant Rat Ctsk Protein E. coli
Rat CTSK-440R Active Recombinant Rat Ctsk Protein E. coli
Rat CTSK-1326R-B Recombinant Rat CTSK Protein Pre-coupled Magnetic Beads HEK293
Rat CTSK-1326R Recombinant Rat CTSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit Ctsk-2763R Recombinant Rabbit Ctsk protein, His-tagged E.coli His 115-329aa
Dog CTSK-328D Recombinant Dog CTSK Protein, His/GST-tagged E.coli His/GST Thr71~Cys319
Dog CTSK-2760D Recombinant Dog CTSK protein, His-SUMO-tagged E.coli His-SUMO 116-330aa
Cattle CTSK-327C Recombinant Cattle CTSK Protein, His-tagged E.coli His His77~Cys318
Cynomolgus monkey CTSK-2762C Recombinant Cynomolgus monkey CTSK protein, His-tagged E.coli His 115-329aa
Rhesus Macaque CTSK-1089R Recombinant Rhesus monkey CTSK Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTSK-914R-B Recombinant Rhesus Macaque CTSK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTSK-914R Recombinant Rhesus Macaque CTSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey (Simian) CTSK-333R Recombinant Rhesus monkey CTSK Protein, His-tagged E.coli His Pro116~Met329
Zebrafish CTSK-2521Z Recombinant Zebrafish CTSK Mammalian Cell His
Pig CTSK-332P Recombinant Pig CTSK Protein, His/GST-tagged E.coli His/GST Lys90~Ala318
Chicken CTSK-6530C Recombinant Chicken CTSK Mammalian Cell His
Kit-2352 Cathepsin K Inhibitor Screening Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSK Related Research Area

CTSK involved in several pathways and played different roles in them. We selected most pathways CTSK participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesMGC174155;TPSAB1;MGC174857;MMP10;MMP24;MMP11;MMP15;MMP13;FURINB
Adaptive Immune SystemCTSD;LAIR2;IGLC2;TREM1;KIF3A;DNM1;AGO1;UBA5;CTSO
Collagen degradationLOC100686744;CTSD;ADAM10;MMP8;TLDC2;MMP20;CTSLL;MGC174155;COL9A1
Degradation of the extracellular matrixMMP10;ADAM9;ADAMTS5;CAPNS1;FAM49BA;CTSG;CTSD;COL17A1;TLL1
Extracellular matrix organizationADAMTS8;LAMC3;NID1;LEPREL1;COL8A1;MFAP4;COL23A1;COL15A1B;MMP17
Immune SystemRBCK1;DYNC1LI2;KIF22;AP1S3A;CASP2;DEFB119;RAP1GAP2;AMICA1;UBE2F
Innate Immune SystemBFB;MB21D1;DDX41;IRF2;TXNIPB;CFD;TREM1;DEFB4B;PELI2
LysosomeHEXA;AP4B1;CTSSA;GNS;AP1M3;NAGLU;CD68;DNASE2;SLC11A1

CTSK has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSK itself. We selected most functions CTSK had, and list some proteins which have the same functions with CTSK. You can find most of the proteins on our site.

Function Related Protein
collagen bindingADAM9;MMP13;DCN;RELL2;PDGFB;SERPINH2;PCOLCE2;PODN;PDGFA
cysteine-type endopeptidase activityUSP17L2;CASP2;USP49;USP22;CTSBA;USP47;CTSL2;CASP6L1;USP42
cysteine-type peptidase activityCTSL1B;CTSB;USP27X;USP17L1P;DESI1;CTSM;USP43A;BLMH;CTSSB.2
fibronectin bindingSFRP2;HSD17B12;CCDC80;IGFBP3;VEGFA;IGFBP5;IGFBP5A;MFAP2;CTGF
protein bindingALOX12B;CDC20B;SH2B2;AKTIP;SSTR2;SF1;RBMY1F;RNF5;AASDHPPT
proteoglycan bindingCECR1A;CTSK;THBS1;CTSL1;FCN2;UBE4A;CTSS;CTSB;COL5A1

CTSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSK.

srp-6; FGFR3; mexB

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CTSK be a target for the development of novel therapeutics for periodontal diseases? 10/10/2022

Yes, CTSK inhibitors are being investigated for their potential in preventing bone loss associated with periodontal diseases.

How does CTSK contribute to the progression of atherosclerosis, and can it be a therapeutic target for cardiovascular diseases? 01/22/2020

CTSK has been linked to vascular calcification in atherosclerosis, and inhibiting its activity may have potential as a therapeutic strategy for cardiovascular diseases.

How might CTSK inhibitors impact the treatment landscape for bone metastasis in cancer patients? 03/26/2018

CTSK inhibitors could potentially be used to limit bone destruction in cancer patients with bone metastasis, improving their quality of life.

Are there any other medical conditions where CTSK inhibitors could be beneficial? 07/29/2017

CTSK inhibitors are being explored for potential therapeutic applications in conditions like rheumatoid arthritis and certain cancers due to their involvement in tissue remodeling.

Are there diagnostic applications for CTSK in identifying bone-related disorders? 11/22/2016

While CTSK is not currently used as a diagnostic marker, its levels and activity could potentially be explored for diagnostic purposes in the future.

Customer Reviews (3)

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Reviews
09/13/2019

    This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.

    01/27/2019

      They have a deep understanding of the CTSK protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.

      12/14/2016

        the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.

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