Active Recombinant Rat Ctsk Protein
Cat.No. : | CTSK-440R |
Product Overview : | Recombinant Rat Ctsk Protein (115-329 aa) without tag was expressed in E. coli. |
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Description : | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). |
Source : | E. coli |
Species : | Rat |
Bio-activity : | The specific activity is >500 mU/mg (1U = 1 μmole/min/mg) as measured by Cathepsin K Activity Assay Kit. |
Molecular Mass : | 23.5 kDa (115-329 aa) |
Purity : | ≥ 90% by SDS–PAGE analysis |
Usage : | For Research Use Only! Not For Use in Humans. |
Storage : | Store at -80 centigrade |
Storage Buffer : | 0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol. |
Shipping : | Dry Ice |
Protein length : | 115-329 |
Gene Name : | Ctsk cathepsin K [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Ctsk |
Synonyms : | Ctsk; cathepsin K; cathepsin K; EC 3.4.22.38; CTSK; CTSO3; CTSO |
Gene ID : | 29175 |
mRNA Refseq : | NM_031560 |
Protein Refseq : | NP_113748 |
UniProt ID : | O35186 |
Products Types
◆ Recombinant Protein | ||
CTSK-1326R | Recombinant Rat CTSK Protein, His (Fc)-Avi-tagged | +Inquiry |
CTSK-439R | Recombinant Rat CTSK Protein (115-329 aa), His-tagged | +Inquiry |
CTSK-2069M | Recombinant Mouse CTSK Protein, His (Fc)-Avi-tagged | +Inquiry |
CTSK-914R | Recombinant Rhesus Macaque CTSK Protein, His (Fc)-Avi-tagged | +Inquiry |
Ctsk-441R | Recombinant Rat Ctsk Protein | +Inquiry |
◆ Lysates | ||
CTSK-7192HCL | Recombinant Human CTSK 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2352 | Cathepsin K Inhibitor Screening Kit (Fluorometric) | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThis guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.
They have a deep understanding of the CTSK protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
Q&As (5)
Ask a questionYes, CTSK inhibitors are being investigated for their potential in preventing bone loss associated with periodontal diseases.
CTSK has been linked to vascular calcification in atherosclerosis, and inhibiting its activity may have potential as a therapeutic strategy for cardiovascular diseases.
CTSK inhibitors could potentially be used to limit bone destruction in cancer patients with bone metastasis, improving their quality of life.
CTSK inhibitors are being explored for potential therapeutic applications in conditions like rheumatoid arthritis and certain cancers due to their involvement in tissue remodeling.
While CTSK is not currently used as a diagnostic marker, its levels and activity could potentially be explored for diagnostic purposes in the future.
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