Recombinant Full Length Human CTSK Protein, GST-tagged

Cat.No. : CTSK-2354HF
Product Overview : Human CTSK full-length ORF ( AAH16058, 15 a.a. - 329 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Source : In Vitro Cell Free System
Species : Human
Tag : GST
Molecular Mass : 60.28 kDa
Protein length : 329 amino acids
AA Sequence : ALYPEEILDTHWELWKKTHRKQYNN KVDEISRRLIWEKNLKYISIHNLEA SLGVHTYELAMNHLGDMTSEEVVQK MTGLKVPLSHSRSNDTLYIPEWEGR APDSVDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSP QNLVDCVSENDGCGGGYMTNAFQYV QKNRGIDSEDAYPYVGQEESCMYNP TGKAAKCRGYREIPEGNEKALKRAV ARVGPVSVAIDASLTSFQFYSKGVY YDESCNSDNLNHAVLAVGYGIQKGN KHWIIKNSWGENWGNKGYILMARNK NNACGIANLASFPKM
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CTSK cathepsin K [ Homo sapiens ]
Official Symbol : CTSK
Synonyms : CTSK; cathepsin K; cathepsin K (pycnodysostosis) , CTSO, CTSO2, PYCD; PKND; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2; CTSO; PYCD; CTS02; CTSO1; CTSO2; MGC23107;
Gene ID : 1513
mRNA Refseq : NM_000396
Protein Refseq : NP_000387
MIM : 601105
UniProt ID : P43235

Not For Human Consumption!

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09/13/2019

    This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.

    01/27/2019

      They have a deep understanding of the CTSK protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.

      12/14/2016

        the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.

        Q&As (5)

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        Can CTSK be a target for the development of novel therapeutics for periodontal diseases? 10/10/2022

        Yes, CTSK inhibitors are being investigated for their potential in preventing bone loss associated with periodontal diseases.

        How does CTSK contribute to the progression of atherosclerosis, and can it be a therapeutic target for cardiovascular diseases? 01/22/2020

        CTSK has been linked to vascular calcification in atherosclerosis, and inhibiting its activity may have potential as a therapeutic strategy for cardiovascular diseases.

        How might CTSK inhibitors impact the treatment landscape for bone metastasis in cancer patients? 03/26/2018

        CTSK inhibitors could potentially be used to limit bone destruction in cancer patients with bone metastasis, improving their quality of life.

        Are there any other medical conditions where CTSK inhibitors could be beneficial? 07/29/2017

        CTSK inhibitors are being explored for potential therapeutic applications in conditions like rheumatoid arthritis and certain cancers due to their involvement in tissue remodeling.

        Are there diagnostic applications for CTSK in identifying bone-related disorders? 11/22/2016

        While CTSK is not currently used as a diagnostic marker, its levels and activity could potentially be explored for diagnostic purposes in the future.

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