ctsl
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  • Official Full Name
  • cathepsin L
  • Background
  • The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
  • Synonyms
  • CTSL; cathepsin L; MEP; CATL; CTSL1; cathepsin L1; major excreted protein; cpl-1; CathePsin L family; CathePsin L family member (cpl-1); cpl 1
Cat.#:CTSL1-405HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human CTSL Protein, His-tagged
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Cat.#:CTSL-2113HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSL Protein, GST-tagged
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Cat.#:CTSL-3380HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSL Protein, MYC/DDK-tagged
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Cat.#:Ctsl-1129MTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Mouse Cathepsin L, His-tagged
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Cat.#:CTSL-137HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSL protein, His-tagged
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Cat.#:CTSL-227HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSL, C13&N15-labeled
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Cat.#:CTSL-421HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSL Protein, His-tagged
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Cat.#:CTSL-54HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTSL, His-tagged
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Cat.#:Ctsl-38MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ctsl Protein, His-tagged
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Cat.#:CTSL-4056MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTSL Protein
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Cat.#:Ctsl-422MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsl Protein, His/GST-tagged
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Cat.#:Ctsl-823MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctsl Protein, His-tagged
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Cat.#:Ctsl-424RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctsl Protein, His-tagged
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Cat.#:CTSL-423PTag:His|GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CTSL Protein, His/GST-tagged
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Cat.#:CTSL-191HTag:N/A
Source (Host):Species:Human
Product nameNative Human Cathepsin L
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Cat.#:CTSL1-1867MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CTSL1 cell lysate
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Cat.#:Kit-2351Tag:N/A
Source (Host):Species:
Product nameCathepsin L Inhibitor Screening Kit (Fluorometric)
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Involved Pathway

Ctsl involved in several pathways and played different roles in them. We selected most pathways Ctsl participated on our site, such as Lysosome, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysosome
GUSB; SGSH; ATP6V0A1B; CD68; CLN3; CTSC; LAMP3; CTSSA; NEU1; PPT2
Phagosome
FCGR2C; STX18; ATP6V0CB; ATP6V0D1; ATP6V0CA; MHC2A; ACTB1; ITGB1; LAMP2; C3A.3
Antigen processing and presentation
HLA-DQA1; IFI30; HLA-DQA2; PDIA3; KIR2DS2; HSPA1B; CTSB; HLA-DRB1; CD4; PSME1
Proteoglycans in cancer
MAP2K2; ERBB2; PPP1R12C; PLCG1; TRP53; TWIST1; PIK3CA; ARHGEF1; PTPN6; RDX
Rheumatoid arthritis
ATP6V0E; ATP6V0E1; HLA-DPA1; Il23a; Il12b; CCL3L1; TGFB3; HLA-DQA1; CCL3; TNFSF11; IL11

Protein Function

Ctsl has several biochemical functions, for example, aminopeptidase activity, cysteine-type carboxypeptidase activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsl itself. We selected most functions Ctsl had, and list some proteins which have the same functions with Ctsl. You can find most of the proteins on our site.
Function
Related Protein
Function aminopeptidase activity
Related Protein Npepo; ERAP2; TPP2; CTSH; LTA4H; XPNPEP2; METAP2B; BLMH; METAP1; RNPEP
Function cysteine-type carboxypeptidase activity
Related Protein CTSL2; Ctsl
Function cysteine-type endopeptidase activity
Related Protein CTSJ; USP13; SFRP1; USP8; CTSO; USP9; USP3; CASP3B; CASP7; USP22
Function cysteine-type peptidase activity
Related Protein CTSSA; USP9; DESI2; PIGK; CAPN2L; CTSBB; USPL1; CASP8L1; OTUD7B; USP43A
Function histone binding
Related Protein NCL; HIST1H4L; HAT1; HIST1H4H; PRKCBB; TBL1X; RAG1; SMARCA2; DTX3L; HIST1H3C
Function hydrolase activity
Related Protein PPM1E; Ren1; PIGL; KLK1B3; ABHD14B; PTPRNA; RHOT1A; Acr; GZMF; NUDT6
Function kininogen binding
Related Protein CTSB; Ctsl; C1QBP; CTSL2
Function peptidase activity
Related Protein GM5136; EGFBP2; CLCA5; HE1B; ELA3L; AGA; ADAMTS7; MPND; CASP8; NPEPPS
Function peptide binding
Related Protein GPR22; FURIN; NLN; PCSK5; IDE; BDKRB1; AVPR2L; QRFPR; GNRHR4; PPIB
Function protein binding
Related Protein SRPX2; ASCL1; EBF2; GYPB; IL1A; NUP85; COMTD1; ALAS2; RBP5; PCBD1
Function protein complex binding
Related Protein IST1; MAPK8IP2; PTK2B; ABI2; CAPG; RARB; RIPK3; PEX1; PPARA; NCK2

Interacting Protein

Ctsl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsl here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsl.
Ctsb; Pi4kb; Serpina3g