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Recombinant Human CTSL protein, His-tagged

Cat.No.: CTSL-137H
Product Overview: Recombinant Human CTSL(18-333 aa) fused with His tag at N-terminal was expressed in E. coli.
Description: CTSL, also known as cathepsin L1 isoform 1, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
Source: E. coli
Species: Human
Tag : His
Form: Liquid. In 20mM Tris-HCl(pH8.0) containing 10% glycerol
Molecular Mass: 38.3kDa (339 aa) confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT
SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG
NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY
FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV
Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity: > 85% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: CTSL cathepsin L [ Homo sapiens ]
Official Symbol: CTSL
Synonyms: MEP; CATL; CTSL1; cathepsin L1; major excreted protein
Gene ID: 1514
mRNA Refseq: NM_001257972
Protein Refseq: NP_001244901
MIM: 116880
UniProt ID: P07711
Chromosome Location: 9q21.33
Pathway: Adaptive Immune System, organism-specific biosystem; Collagen degradation, organism-specific biosystem; Lysosome, conserved biosystem
Function: collagen binding; cysteine-type endopeptidase activity; proteoglycan binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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