cyp17a1
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  • Official Full Name
  • cytochrome P450, family 17, subfamily A, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
  • Synonyms
  • CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; CYP17, cytochrome P450, subfamily XVII (steroid 17 alpha hydroxylase), adrenal hyperplasia; steroid 17-alpha-hydroxylase/17,20 lyase; CPT7; P450C17; S17AH; Steroid 17 alpha monooxygenase; 20 lyase; CP17A_HUMAN; CYP17; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
Cat.#:CYP17A1-2241HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP17A1 Protein, GST-tagged
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Cat.#:CYP17A1-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cytochrome P450 17A1
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Cat.#:CYP17A1-11763HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP17A1, GST-tagged
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Cat.#:CYP17A1-2115HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP17A1 protein, His & T7-tagged
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Cat.#:CYP17A1-928HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CYP17A1
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Cat.#:Cyp17a1-2116MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cyp17a1 protein, His & T7-tagged
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Cat.#:CYP17A1-4147MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP17A1 Protein
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Cat.#:CYP17A1-1714RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP17A1 Protein
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Cat.#:Cyp17a1-2117RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cyp17a1 protein, His & T7-tagged
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Cat.#:CYP17A1-1135RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP17A1 Protein, His-tagged
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Cat.#:CYP17A1-1182CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP17A1
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Cat.#:CYP17A1-12072ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYP17A1
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Cat.#:CYP17A1-7128HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP17A1 293 Cell Lysate
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Involved Pathway

CYP17A1 involved in several pathways and played different roles in them. We selected most pathways CYP17A1 participated on our site, such as Androgen biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP17A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Androgen biosynthesis
POMCB; PPP1R2; CYP17A1; CGA
Biological oxidations
SULT1ST6; CYP2K18; CYP46A1; CYP51A1; DPEP2; CYP2V1; UGT1B7; SULT1ST5; FAM84B; ADH1C
Cytochrome P450 - arranged by substrate type
CYP2N13; FDXR; CYP2S1; CYP3A7-CYP3AP1; CYP2C18; CYP4F22; CYP51A1; CYP2V1; CYP2K19; POMCB
Endogenous sterols
CYP8B2; CYP1B1; CYP17A1; CYP51A1; FDX1; CYP11B1; POMCB; CYP7A1; FDX1L; FDXR
Glucocorticoid &
CYP17A1; CYP21A2; AKR1C21; CYP11B2
amp
CYP11B2; CYP21A2; CYP17A1; AKR1C21
Mineralcorticoid Metabolism
CYP11B2; CYP21A2; AKR1C21; CYP17A1
Glucocorticoid biosynthesis
CYP11B2; CYP17A1; CYP11B1; CYP21A2
Metabolic pathways
NDUFB6; CYP2R1; TK1; PLA2G2E; DPYDB; UGT8A; MAT2AL; LDHB; G6PD; ATP5F1
Metabolism
CYP3A7; CKMT2A; COX16; NDUFAF4; LYRM4; FAAH2; KCNJ11; SAT1B; ANKRD1; SULT2ST1

Protein Function

CYP17A1 has several biochemical functions, for example, 17-alpha-hydroxyprogesterone aldolase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP17A1 itself. We selected most functions CYP17A1 had, and list some proteins which have the same functions with CYP17A1. You can find most of the proteins on our site.
Function
Related Protein
Function 17-alpha-hydroxyprogesterone aldolase activity
Related Protein CYP17A1
Function heme binding
Related Protein CYP3C1; CYP2X10.2; CYP2A6; CYP4V8; CYP2P8; SDHD; CYP46A1.4; CYP4F12; STC2; MB
Function iron ion binding
Related Protein CYP27C1; CYP2K16; NOS2; CYP51A1; ALOX5B.3; CYP4F14; CYP11B1; CYP2K18; CYGB2; CYP2W1
Function oxygen binding
Related Protein CYP2X9; CYP3A4; CYP2C54; CYP2P9; HBAE3; HBE1; CYP2A12; FAM84B; CYP2E1; CYP2F2
Function steroid 17-alpha-monooxygenase activity
Related Protein CYP17A2; CYP17A1

Interacting Protein

CYP17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP17A1.
CHEK2; ERBB2; IGF1R; HSP90AB1; CDH1; APC; ATP5E; PTPRJ; STK11; CDO1; TIGD7; RPAIN; BARX1

CYP17A1 Related Articles

Chand, S; Mustafa, MD; et al. CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 180:100-105(2014).
Remnant, JG; Lea, RG; et al. Novel gonadal characteristics in an aged bovine freemartin. ANIMAL REPRODUCTION SCIENCE 146:1-4(2014).