CYP17A1

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CYP17A1

Official Full Name cytochrome P450, family 17, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Synonyms CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; CYP17, cytochrome P450, subfamily XVII (steroid 17 alpha hydroxylase), adrenal hyperplasia; steroid 17-alpha-hydroxylase/17,20 lyase; CPT7; P450C17; S17AH; Steroid 17 alpha monooxygenase; 20 lyase; CP17A_HUMAN; CYP17; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 XVIIA1; Cytochrome p450, subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP17A1-02H Recombinant Human CYP17A1 Protein E.coli
    Mouse Cyp17a1-2410M Recombinant Mouse Cyp17a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CYP17A1-4348H Recombinant Human CYP17A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP17A1-87H Recombinant Human CYP17A1 Protein E. coli
    Human CYP17A1-01H Recombinant Human Cytochrome P450 17A1 E.coli N/A
    Human CYP17A1-11763H Recombinant Human CYP17A1, GST-tagged E.coli GST
    Human CYP17A1-2115H Recombinant Human CYP17A1 protein, His & T7-tagged E.coli His/T7
    Human CYP17A1-2241H Recombinant Human CYP17A1 Protein, GST-tagged Wheat Germ GST
    Human CYP17A1-7128HCL Recombinant Human CYP17A1 293 Cell Lysate HEK293 N/A
    Human CYP17A1-928H Recombinant Human CYP17A1 Mammalian Cell His
    Mouse Cyp17a1-2116M Recombinant Mouse Cyp17a1 protein, His & T7-tagged E.coli His/T7
    Mouse CYP17A1-4147M Recombinant Mouse CYP17A1 Protein Mammalian Cell His
    Rat CYP17A1-1714R Recombinant Rat CYP17A1 Protein Mammalian Cell His
    Rat Cyp17a1-2117R Recombinant Rat Cyp17a1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CYP17A1-1135R Recombinant Rhesus monkey CYP17A1 Protein, His-tagged Mammalian Cell His
    Chicken CYP17A1-1182C Recombinant Chicken CYP17A1 Mammalian Cell His
    Zebrafish CYP17A1-12072Z Recombinant Zebrafish CYP17A1 Mammalian Cell His

    CYP17A1 involved in several pathways and played different roles in them. We selected most pathways CYP17A1 participated on our site, such as Androgen biosynthesis, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP17A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Androgen biosynthesis CYP17A1; POMCB; PPP1R2; CGA
    Biological oxidations ABHD10; CYP3A5; CYP2W1; CYP19A1; CYP3A7; CYP8B2; ACSM1; ADH1B; GLYATL2; GGTLC1
    Cytochrome P450 - arranged by substrate type CYP2B6; CYP2C18; CYP11B1; CYP2AD6; CYP11B2; CYP2D6; FDXR; CYP2R1; CYP2AD3; CYP2K19
    Endogenous sterols CYP7A1; CYP11A1; CYP27A1; FDX1; POMCB; CYP46A1; CYP21A2; FDXR; FDX1L; CYP51A1
    Glucocorticoid &amp AKR1C21; CYP11B2; CYP17A1; CYP21A2
    amp AKR1C21; CYP17A1; CYP21A2; CYP11B2
    Mineralcorticoid Metabolism AKR1C21; CYP21A2; CYP11B2; CYP17A1
    Glucocorticoid biosynthesis CYP17A1; CYP11B1; CYP11B2; CYP21A2
    Metabolic pathways SCP2; CYP4A10; UGT1A9; PGAM1A; MAN1A2; CYP3A65; B3GNT6; CYP3A41A; HEXA; CYP2C37
    Metabolism SLC25A15A; CYP2K8; ADAL; GGT6; GLTPA; GNG13A; AK7A; ATP5S; SLC6A7; DGUOK

    CYP17A1 has several biochemical functions, for example, 17-alpha-hydroxyprogesterone aldolase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP17A1 itself. We selected most functions CYP17A1 had, and list some proteins which have the same functions with CYP17A1. You can find most of the proteins on our site.

    Function Related Protein
    17-alpha-hydroxyprogesterone aldolase activity CYP17A1
    heme binding CYP20A1; CYP2P7; DGCR8; CYP2AD3; CYP4F18; HMOX1; CYP4A10; CYP2AA2; CYB5A; PTGESL
    iron ion binding CYP2B6; HBAA; CYGB; CYP2A12; CALR; CYP26A1; CYP2H1; FTL; MFI2; SLC11A2
    oxygen binding HBB-Y; HBG1; HBB; CYP2W1; HBAA1; BA1; CYP2J6; TDO2; FAM84B; HBZ
    steroid 17-alpha-monooxygenase activity CYP17A2; CYP17A1

    CYP17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP17A1.

    CHEK2; ERBB2; IGF1R; HSP90AB1; CDH1; APC; ATP5E; PTPRJ; STK11; CDO1; TIGD7; RPAIN; BARX1

    Chand, S; Mustafa, MD; et al. CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 180:100-105(2014).
    Remnant, JG; Lea, RG; et al. Novel gonadal characteristics in an aged bovine freemartin. ANIMAL REPRODUCTION SCIENCE 146:1-4(2014).

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