dpyd
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  • Official Full Name
  • dihydropyrimidine dehydrogenase
  • Background
  • The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Synonyms
  • DPYD; dihydropyrimidine dehydrogenase; DHP; DPD; DHPDHASE; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase;
Cat.#:DPYD-2533HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPYD Protein, MYC/DDK-tagged
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Cat.#:DPYD-2860HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPYD Protein, GST-tagged
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Cat.#:DPYD-2111HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DPYD protein, His & T7-tagged
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Cat.#:DPYD-28435THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYD
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Cat.#:DPYD-28437THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPYD
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Cat.#:Dpyd-2112MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dpyd protein, His & T7-tagged
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Cat.#:DPYD-4810MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPYD Protein
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Cat.#:DPYD-1947RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DPYD Protein
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Involved Pathway

DPYD involved in several pathways and played different roles in them. We selected most pathways DPYD participated on our site, such as Drug metabolism - other enzymes, Fluoropyrimidine Activity, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Drug metabolism - other enzymes
UGT1AB; Ces2e; UGT1A4; UGT1A1; DPYDB; UGT1A7; UGT1A6B; UPB1; UCK2A; PNAT10
Fluoropyrimidine Activity
UPP2; DPYD; DPYS; SLC22A7; DHFR; TYMP; CES1
Metabolic pathways
MCAT; ST3GAL6; TUSC3; SMPD4; DGUOK; POLG; NAMPT; ANPEP; ALDH1A3; COX11
Metabolism
CYP2Y3; DAO; ADSL; CSNK1G2; COX6B1; AKR1B15; MMADHC; CDO1; COX18; DECR1
Metabolism of nucleotides
NUDT18; DPYS; NUDT1; ADSS; AK7; DHODH; NUDT16; AK7A; AK8; PAICS
Pantothenate and CoA biosynthesis
ENPP1; VNN2; PANK1B; VNN1; PANK1; BCAT2; BCAT1; AASDHPPT; UPB1; DPYS
Pyrimidine catabolism
DPYDA.1; UPP2; PROZA; DPYS; TYMP; DPYD
Pyrimidine metabolism
POLR2C; ENTPD5; POLR2J3; NT5C1AA; TXNRD2; NT5C; POLR1C; POLR2J2; NT5C1A; NME4

Protein Function

DPYD has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, NADP binding, dihydropyrimidine dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYD itself. We selected most functions DPYD had, and list some proteins which have the same functions with DPYD. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein DPYD; LIAS; CDKAL1; MUTYH; ACO1; NDUFS8; DPYDB; ERCC2; POLA1; RSAD1
Function NADP binding
Related Protein ASPDH; HMGCRB; FMO1; SPR; GAPDHS; POR; MIOX; NDOR1; G6PD; NOX5
Function dihydropyrimidine dehydrogenase (NADP+) activity
Related Protein DPYDB; DPYD
Function flavin adenine dinucleotide binding
Related Protein ACADVL; LDHD; XDH; AOX1; FMO2; KDM1B; ETFDH; TXNRD2; ACADL; AOX3L1
Function metal ion binding
Related Protein RNF44; ZFP335; CYP2D26; CYP2C39; AGAP5; TIMP1; C1GALT1A; DPYD; ACLYA; ZC3H13
Function protein binding
Related Protein MAP4K3; EIF4G2; HPCAL1; THOC2; NANOS2; ANO2; C4orf46; RPRD1B; PACS1; CXXC1
Function protein homodimerization activity
Related Protein HNF1B; SLC11A1; CAMK2B; CADM1A; ALDH1A3; NR2C1; IZUMO3; PYCARD; SMAD3; ERCC5

Interacting Protein

DPYD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYD here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYD.
LXN; GOPC; fyuA; pelY; gyrA; q7cj40_yerpe; q7cjh7_yerpe; ebgC1; vacB; smc3; yapH; q8d0h5_yerpe; clpA3; phnK; xerC; tcaC1