| Description : |
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
111.4 kDa |
| AA Sequence : |
MAPVLSKDSADIESILALNPRTQTH ATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGERGALRE AMRCLKCADAPCQKSCPTNLDIKSF ITSIANKNYYGAAKMIFSDNPLGLT CGMVCPTSDLCVGGCNLYATEEGPI NIGGLQQFATEVFKAMSIPQIRNPS LPPPEKMSEAYSAKIALFGAGPASI SCASFLARLGYSDITIFEKQEYVGG LSTSEIPQFRLPYDVVNFEIELMKD LGVKIICGKSLSVNEMTLSTLKEKG YKAAFIGIGLPEPNKDAIFQGLTQD QGFYTSKDFLPLVAKGSKAGMCACH SPLPSIRGVVIVLGAGDTAFDCATS ALRCGARRVFIVFRKGFVNIRAVPE EMELAKEEKCEFLPFLSPRKVIVKG GRIVAMQFVRTEQDETGKWNEDEDQ MVHLKADVVISAFGSVLSDPKVKEA LSPIKFNRWGLPEVDPETMQTSEAW VFAGGDVVGLANTTVESVNDGKQAS WYIHKYVQSQYGASVSAKPELPLFY TPIDLVDISVEMAGLKFVNPFGLAS ATPATSTSMIRRAFEAGWGFALTKT FSLDKDIVTNVSPRIIRGTTSGPMY GPGQSSFLNIELISEKTAAYWCQSV TELKADFPDNIVIASIMCSYNKNDW TELAKKSEDSGADALELNLSCPHGM GERGMGLACGQDPELVRNICRWVRQ AVQIPFFAKLTPNVTDIVSIARAAK EGGANGVTATNTVSGLMGLKSDGTP WPAVGIAKRTTYGGVSGTAIRPIAL RAVTSIARALPGFPILATGGIDSAE SGLQFLHSGASVLQVCSAIQNQDFT VIEDYCTGLKALLYLKSIEELQDWD GQSPATVSHQKGKPVPRIAELMDKK LPSFGPYLEQRKKIIAENKIRLKEQ NVAFSPLKRNCFIPKRPIPTIKDVI GKALQYLGTFGELSNVEQVVAMIDE EMCINCGKCYMTCNDSGYQAIQFDP ETHLPTITDTCTGCTLCLSVCPIVD CIKMVSRTTPYEPKRGVPLSVNPVC TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
