Recombinant Full Length Human DPYD Protein, C-Flag-tagged
Cat.No. : | DPYD-503HFL |
Product Overview : | Recombinant Full Length Human DPYD Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 111.2 kDa |
AA Sequence : | MAPVLSKDSADIESILALNPRTQTH ATLCSTSAKKLDKKHWKRNPDKNCF NCEKLENNFDDIKHTTLGER GALREAMRCLKCADAPCQKSCPTNL DIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGC NLYATEEGPINIGGLQQFATEVFKA MSIPQIRNPSLPPPEKMSEAYSAKI ALFGAGPASISCASFLARLG YSDITIFEKQEYVGGLSTSEIPQFR LPYDVVNFEIELMKDLGVKIICGKS LSVNEMTLSTLKEKGYKAAF IGIGLPEPNKDAIFQGLTQDQGFYT SKDFLPLVAKGSKAGMCACHSPLPS IRGVVIVLGAGDTAFDCATS ALRCGARRVFIVFRKGFVNIRAVPE EMELAKEEKCEFLPFLSPRKVIVKG GRIVAMQFVRTEQDETGKWN EDEDQMVHLKADVVISAFGSVLSDP KVKEALSPIKFNRWGLPEVDPETMQ TSEAWVFAGGDVVGLANTTV ESVNDGKQASWYIHKYVQSQYGASV SAKPELPLFYTPIDLVDISVEMAGL KFVNPFGLASATPATSTSMI RRAFEAGWGFALTKTFSLDKDIVTN VSPRIIRGTTSGPMYGPGQSSFLNI ELISEKTAAYWCQSVTELKA DFPDNIVIASIMCSYNKNDWTELAK KSEDSGADALELNLSCPHGMGERGM GLACGQDPELVRNICRWVRQ AVQIPFFAKLTPNVTDIVSIARAAK EGGANGVTATNTVSGLMGLKSDGTP WPAVGIAKRTTYGGVSGTAI RPIALRAVTSIARALPGFPILATGG IDSAESGLQFLHSGASVLQVCSAIQ NQDFTVIEDYCTGLKALLYL KSIEELQDWDGQSPATVSHQKGKPV PRIAELMDKKLPSFGPYLEQRKKII AENKIRLKEQNVAFSPLKRN CFIPKRPIPTIKDVIGKALQYLGTF GELSNVEQVVAMIDEEMCINCGKCY MTCNDSGYQAIQFDPETHLP TITDTCTGCTLCLSVCPIVDCIKMV SRTTPYEPKRGVPLSVNPVCTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism |
Gene Name : | DPYD dihydropyrimidine dehydrogenase [ Homo sapiens (human) ] |
Official Symbol : | DPYD |
Synonyms : | DHP; DPD; DYPD; DHPDHASE |
Gene ID : | 1806 |
mRNA Refseq : | NM_000110.4 |
Protein Refseq : | NP_000101.2 |
MIM : | 612779 |
UniProt ID : | Q12882 |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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