| Official Full Name | E1A binding protein p300 |
| Background | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. |
| Synonyms | EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | MAPK3; ATP1B4; PPP1CC; PDE4B; PDE3B; SUCNR1; PRKACB; CALML5; ACOX3; GRIN2B |
| HIF- signaling pathway | PIK3R5; ENO3; ANGPT2; PRKCG; PIK3CA; NPPA; ANGPT4; MAPK3; PIK3CG; FLT1 |
| FoxO signaling pathway | PTENB; MAPK1; PRKAB1; PRKAG1; MAP2K2; MAPK14B; INS; BNIP4; MAPK10; SMAD4 |
| Cell cycle | CEP63; CDK5RAP2; DKC1; CEP290; NCAPD3; HIST3H2BB; ARPP19B; E2F4; CLSPN; KAT5 |
| Wnt signaling pathway | CAMK2B1; FZD1; FZD5; WNT2BA; SFRP1; WNT11R; WNT11B; WNT4A; RHOA; FBXW11B |
| Notch signaling pathway | RBPJA; APH1B; NOTCH4; PSEN2; MAML1; LFNG; NOTCH3; KAT2B; HER15.1; MFAP5 |
| TGF-beta signaling pathway | ACVR2B; ACVR1; ACVR2A; RHOAC; RHOA; BMPR2A; ID4; SMAD1; BMPR1BB; BMPR1AB |
| Adherens junction | CDC42L2; BAIAP2; INSRB; PVRL4; CTNNA1; SNAI1; SSX2IP; PVRL3B; RAC3B; WASLA |
| Jak-STAT signaling pathway | Il23a; Il12b; EP300; PIAS1; PIK3R3; Ifna11; FHL1B; IFNA21; AOX3; STAT5B; IL12A |
| Long-term potentiation | CALML5; GRIN2B; PPP3CB; RPS6KA3; PRKACB; CALML3; CAMK4; ARAF; RAF1; PPP1CC |
| Melanogenesis | WNT10B; CALML5; WNT11B; GNA15.4; WNT2; FZD7A; WNT9B; CALM2A; KITLG; PRKACB |
| Thyroid hormone signaling pathway | MED24; MED12; BMP4; TBC1D4; PIK3R5; PLCE1; AKT1; ATP1B1; MED27; PLCG1 |
| Glucagon signaling pathway | SLC2A2; ITPR1; PGAM2; LDHA; PLCB2; ATF4; LDHAL6B; PLCB1; PCK2; PPARGC1A |
| Huntingtons disease | UQCRC1; DNAH14; NDUFV3; ATP5G1; EP300; DNAL4; DNALC4; ATP5B; ATP5H; HDAC2 |
| Tuberculosis | TGFB2; MAPK9; CD209B; IFNGR1; HLA-DPA1; H2-AA; LAMP2; RELA; CYCS; ITGB2L |
| Hepatitis B | STAT5B; MAPK3; CCNE2; ELK1; IFNA14; NFATC1; RELA; CCND1; NFATC2; TICAM2 |
| Influenza A | ADAR; TNFRSF10B; IFNA2; BLA; IFNB; ICAM1; BCL2L2-PABPN1; IFNGR2; GSK3B; IRF7 |
| HTLV-I infection | NFATC4; PDGFRB; WNT7A; WNT16; CD3D; TP53; ANAPC7; AKT1; H2-AA; H2-AB1 |
| Herpes simplex infection | BMA2; STAT1A; STAT2; ALYREF; Ccl12; TRAF2; HLA-DQB1; MAPK10; HLA-DPA1; PVRL2 |
| Epstein-Barr virus infection | MAP2K7; TAB1; HLA-DRB5; POLR2L; AKT2; PSMC6; POLR3K; POLR1D; PRKACG; HLA-DRB4 |
| Pathways in cancer | BAD; ITGA6; WNT8A; SMO; RASGRP3; FZD7; TRAF3; PRKCA; BDKRB1; HDAC2 |
| Viral carcinogenesis | HDAC10; HIST1H2BN; RBL2; CDK1; IKBKG; SRF; HIST1H2BL; PIK3R3; PIK3R2; SND1 |
| MicroRNAs in cancer | MDM4; UBE2I; BCL2L2; TNC; DNMT1; IRS1; APC; MAP2K1; SOCS1; ABCB1A |
| Renal cell carcinoma | RAF1; HRAS; TGFA; TCEB2; ARAF; ETS1; VEGFA; TCEB1; PAK3; AHA-1 |
| Prostate cancer | CCND1; SPRY1; GRB2; PDGFRB; SOS1; AKT2; CASP9; BAD; RAF1; NOXA1 |
EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | MTF2; THOC1; POLG; MAFGA; SMARCC1B; CCDC71L; GABPA; E2F1; HOXA9A; HOXD11A |
| NF-kappaB binding | HDAC2; MTDH; BCL10; FAF1; CDK5RAP3; DNAJA3; ANXA4; RPS3; EP300; HDAC1 |
| RNA polymerase II activating transcription factor binding | SMAD3; HNF4A; EP300; EGR2; PITX2; HIPK2; SETD3; LDB1; EOMES; NFE2L2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX6-1; ZNF395; KCNIP3; HOXD13; MYPOP; SMAD2; LEF1; FOXJ2; SKIL; CEBPG |
| RNA polymerase II core promoter sequence-specific DNA binding | MTF1; EGR1; NR4A2; SMAD1; SMYD3; MAZ; NFIL3; TRP53; MITF; YAP1 |
| SMAD binding | STUB1; SKILB; RNF111; SKOR1A; BMP2; TGFBR1; FKBP1A; PRDM16; SKI; SMURF2 |
| acetyltransferase activity | KAT8; CML2; EP300; LPCAT3; NAT14; KAT5; Acnat1; ACNAT2; AANAT1; CREBBP |
| activating transcription factor binding | PRDM16; TAF9; EEF1D; PPARG; HDAC7; ZFP516; MEF2D; DGKQ; SMAD2; PSIP1 |
| androgen receptor binding | GRIP1; PRKCBB; KDM3A; NRIP1; KAT5; RB1; TCF21; NSD1; DDX5; BRCA1 |
| bHLH transcription factor binding | EP300; MAP3K10; TCF3A; LMO2; USF1; HAND1; TWIST1; PSMD9; TCF12; TCF3 |
| beta-catenin binding | CARM1; PXN; PTPRU; SHROOM2; ESR1; GSK3B; SOX17; CALCOCO1; AXIN2; KLF4 |
| chromatin DNA binding | EZH2; GRHL3; H1F0; RELA; PER1; RXRA; APEX1; XBP1; MED1; ZIC2 |
| chromatin binding | SIRT2; ZGLP1; CHD8; MLL1; TCF7L1B; STAT5B; CREBBP; TICRR; SMAD2; NR5A2 |
| core promoter binding | NPAS2; E2F8; MYOG; IFI16; INSM1A; HDAC4; NKX3-1; ARNTL; MYBBP1A; E2F3 |
| damaged DNA binding | DCLRE1C; PCNA; H2AFX; CRY2; NEIL2; XRCC6; OGG1; TRP53; TP73; POLI |
| glucocorticoid receptor binding | NR4A2; YWHAH; GRIP1; CEBPB; FKBP4; EP300; ETS2; STAT3; STAT5B; NRIP1 |
| histone acetyltransferase activity | KAT6B; EP300; TAF1L; NCOA2; HTATIP; MED24; HAT1; KAT7A; KAT7; KAT2A |
| lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | EP300; ESCO2; NAT8B; KAT2B; CEACAM21; NAT8; RHBDL1 |
| mitogen-activated protein kinase binding | GTF2I; PTPRJ; DUSP2; ABL1; ACE; SIRT1; NBR1; MAPKAPK2B; PLCB4; MAPKAPK5 |
| nuclear hormone receptor binding | CTNNB1; CRY1; HIF1A; SIRT1; TACC2; NCOR1; TCF7L2; Ankar; MYOD1; NCOA1 |
| p53 binding | SETD7; USP10; ZFP346; TP53; AXIN1; CDK5; TP63; TRIM29; ZNF385C; ZNF385D |
| peroxisome proliferator activated receptor binding | ASXL2; HMGA1-RS1; HMGA1; EP300; IKBKG; NR0B2; ASXL1; MED1; CREBBP; PPARGC1A |
| pre-mRNA intronic binding | HNRNPA2B1; RBM41; EP300; SOX9; RNPC3; RBM4; PRPF8 |
| protein C-terminus binding | ERCC6; DYNLL1; PLEKHB1; ERCC2; DAB2; BAIAP2; AP2A1; CEP135; PIAS3; SIAH1A |
| protein antigen binding | KLRC2; H2-AB1; EP300; ITGA4; KLRD1 |
| protein binding | YWHAE; CNTNAP2; KLC1; CXCR7; RASGRP3; C1QTNF9; APBA3; KTI12; CAMK2D; TBC1D9B |
| protein complex binding | VHLL; RPTOR; HCLS1; EPHB1; PGAM5; PPIB; CPS1; ATF1; PDCL; FBN1 |
| transcription coactivator activity | JUNB; NR1H3; HAND1; ENY2; FUS; ELF3; TFAP2B; PCBD1; KDM5A; MED14 |
| contributes_to transcription coactivator activity | CREBBP; PHF2; EP300; ARID5B |
| transcription factor binding | CTNNB1; PPRC1; PARD6A; EPN1; PAX6; DIP2B; TRERF1; TRIB2; PPID; HTT |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | FOXO3; BARX2; RFX6; CREBBP; BHLHA15; TRP53; REST; IKZF3; CREB3L4; MAF |
| transferase activity, transferring acyl groups | ZDHHC18; GGT7; DGAT2L6; AANAT; EP300; CHAC2; CDYL; MBOAT7; CML5; LIPT2 |
| zinc ion binding | MT1B; MORC2; ZDHHC24; FTR54; DNMT1; GCH2; MYLIP; LMCD1; PJA2; RNF138 |
EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.
HIF1A; TP53
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