f2r
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  • Official Full Name
  • Coagulation factor II (thrombin) receptor
  • Background
  • There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.
  • Synonyms
  • Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR-1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR
Cat.#:F2R-367HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human F2R Protein, His-tagged
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Cat.#:F2R-3613HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human F2R Protein, GST-tagged
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Cat.#:F2R-31176THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human F2R
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Cat.#:F2R-375HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human F2R
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Cat.#:F2R-5409MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse F2R Protein
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Cat.#:F2R-6482ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish F2R
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Cat.#:F2R-2116HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human F2R cell lysate
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Cat.#:Kit-1232Tag:N/A
Source (Host):Species:
Product nameF2R (PAR1) CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0927Tag:N/A
Source (Host):Species:
Product nameTR-FRET PPAR alpha Competitive Binding Assay Kit, rabbit
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Involved Pathway

F2R involved in several pathways and played different roles in them. We selected most pathways F2R participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
RAC3; IGF1R; ACTB; RALGDS; HGF; RHOA; NRAS; INS; PRKCG; Adcy4
Calcium signaling pathway
HTR2CL1; PRKCG; ORAI2; P2RX2; PLCD3; CALM3; ADRA1BB; PRKACBB; P2RX3A; CAMK2D1
cAMP signaling pathway
RELA; HTR4; EP300; PDE4B; HTR1A; ROCK2; CALM2; Adcy4; FSHB; GPR81
Phospholipase D signaling pathway
CYTH1; LPAR6; RALB; GRM2; AVPR1A; GRM8; TSC1; PDGFA; CYTH3; DGKZ
Neuroactive ligand-receptor interaction
ADRA2DB; PRSS2; RXFP2; LHB; TACR2; NPFFR2; NPY8AR; MCHR2; GHSRA; GNRHR2
Endocytosis
CCR5; WIPF2B; EHD3; SMAD3; RAB11AL; VPS25; FAM21A; RAB5AB; FAM125B; ZFP652
PIK-Akt signaling pathway
SOS1; RPTOR; RPS6; MAPK3; ITGB8; PKN1; GNG11; CCNE1; RHEB; FGF13
Complement and coagulation cascades
GM5077; CR2; CPB2; FGB; Serpina1b; TFPI; SERPINA5; F11; C1QC; F8
Platelet activation
PLA2G4A; PPP1CB; PLCB1; GNAI1; COL27A1; APBB1IP; PLA2G4C; PRKG2; FGG; ACTG1
Regulation of actin cytoskeleton
INS; VIL1; LIMK1A; EZR; TMSB4X; ITGA8; PIK3R2; PIK3CA; MYLK; FGFR1
Pathways in cancer
ITGB1; PRKCB; PDGFB; TCF7; RAF1; PLCG1; PIAS2; RHOA; STAT3; Ar

Protein Function

F2R has several biochemical functions, for example, G-protein alpha-subunit binding, G-protein beta-subunit binding, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F2R itself. We selected most functions F2R had, and list some proteins which have the same functions with F2R. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein alpha-subunit binding
Related Protein RGS19; LPAR3; LPAR1; DRD1A; RGS4; NUCB1; F2RL1; ARHGEF11; OPRM1; HTR2B
Function G-protein beta-subunit binding
Related Protein OPRM1; RGS7; GNG13; F2RL1; RASD2; F2R; RGS11; RGS9; CCT5; GNG2
Function G-protein coupled receptor activity
Related Protein OR6Q1; ADORA2AA; OLFR495; PROKR1A; TAAR5; NPFFR2.1; FZD3; CELSR1; PTGER4B; CXCR1
Function protein binding
Related Protein PRPF4B; SELENBP1; NOTCH2NL; NPPA; TBC1D7; KRTAP9-4; POU3F3; PTGER4; MITF; CACNG1
Function receptor binding
Related Protein DRD1A; CADM2A; ENSA; GNPAT; PKD2; PLA2G1B; Itga10&Itgb1; HAO1; AKAP9; GSTM7
Function thrombin receptor activity
Related Protein F2RL1.1; F2RL1.2; F2R; F2RL1; F2RL2; GP1BA

Interacting Protein

F2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2R here. Most of them are supplied by our site. Hope this information will be useful for your research of F2R.
PROCR; MMP1; CAPN1; GNA13; TMED2; purL; CHRD; ATP13A2; CAV1

F2R Related Articles

Sung, TS; Kim, HU; et al. Protease-activated receptors modulate excitability of murine colonic smooth muscles by differential effects on interstitial cells. JOURNAL OF PHYSIOLOGY-LONDON 593:1169-1181(2015).
D'Asti, E; Kool, M; et al. Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:1838-1849(2014).

F2R Related Gene Family

GPCRs