Native Human F2R Protein F2R-27H

Native Human F2R Protein

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Native Human F2R Protein

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Cat.No. : F2R-27H
Product Overview : Native human F2R protein without tag was isolated from human blood.
Description : Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII. Conversely, thrombin aids the anticoagulant process by activating protein C. Activated protein C inhibits activated factors V and VIII ultimately down-regulating further thrombin production. Thrombin is often used as a potent platelet activator in vitro. Platelet responses to thrombin are mediated through protease-activated receptors (PARs). Thrombin-mediated signaling regulates a diverse range of metabolic processes including activation of phospholipases in platelets, endothelial cells, and cardiac myocytes.
Source : Human Blood
Species : Human
Molecular Mass : 38 kDa
Stability : ≥ 1 year
Storage : Store it at -80 centigrade
Storage Buffer : 5 mM sodium citrate, pH 6.5, containing 0.01% PEG and 20 mM sodium chloride
Gene Name : F2R coagulation factor II thrombin receptor [ Homo sapiens (human) ]
Official Symbol : F2R
Synonyms : F2R; coagulation factor II thrombin receptor; TR; HTR; CF2R; PAR1; PAR-1; proteinase-activated receptor 1; protease-activated receptor 1
Gene ID : 2149
mRNA Refseq : NM_001311313
Protein Refseq : NP_001298242
MIM : 187930
UniProt ID : P25116

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