FCGR3A Protein, Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)

FCGR3A

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FCGR3A

Official Full Name Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)
Background This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CD 16; CD 16a; CD16A; CD16a antigen; CD16B; CD16b antigen; Fc fragment of IgG; Fc fragment of IgG low affinity IIIa receptor (CD16); Fc fragment of IgG, low affinity III, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc gamma R3; Fc gamma receptor IIIA; Fc gamma receptor IIIb (CD 16); Fc gamma RIII alpha; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIa; Fc gamma RIIIb; Fc of IgG; Fc-gamma receptor III2 (CD 16); Fc-gamma receptor III2 (CD16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG 3; FCG3; FCG3A_HUMAN; FCgammaRIIIA; FCGR 3; FCGR 3A; FCGR3; FCGR3A; FCGR3A protein; FCGRIII; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIa; IGFR 3; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III 2; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; Low affinity IIIa receptor; Low affinity immunoglobulin gamma Fc region receptor III A; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IIIB; neutrophil-specific antigen NA
    • Species :
    • Human
    • Rat
    • Source :
    • CHO
    • CHO Cells
    • E.coli
    • HEK293
    • Human Cell
    • Mouse
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FCGR3A-7288H Recombinant Human FCGR3A protein, His-tagged, 176 Val CHO Cells His
    Human FCGR3A-001HCL Recombinant Human FCGR3A cell lysate CHO N/A
    Human FCGR3A-1999HCL Recombinant Human FCGR3A cell lysate Human Cell N/A
    Human FCGR3A-261H Recombinant Human FCGR3A, His-tagged, Biotinylated HEK293 His
    Human FCGR3A-2965H Recombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Val Human Cell His/Avi
    Human FCGR3A-2966H Recombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Phe Human Cell His/Avi
    Human FCGR3A-309H Recombinant Human FCGR3A, His-tagged NS0 His
    Human FCGR3A-3830H Recombinant Human FCGR3A, His & AVI tagged Human Cell His/Avi
    Human FCGR3A-3995H Recombinant Human FCGR3A Protein Wheat Germ N/A
    Human FCGR3A-3996H Recombinant Human FCGR3A Protein, GST-tagged Wheat Germ GST
    Human FCGR3A-625H Recombinant Human FCGR3A, His-tagged, 176 Phe HEK293 His
    Human FCGR3A-626H Recombinant Human FCGR3A Protein, His-tagged HEK293 His
    Human FCGR3A-6942H Recombinant Human Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a), His-tagged E.coli His
    Human FCGR3A-7287H Recombinant Human FCGR3A, His tagged CHO His
    Rat CAB11540RM Mouse Anti-Rat CD16a Monoclonal Antibody Mouse N/A
    Rat FCGR3A-1969RCL Recombinant Rat FCGR3A cell lysate Human Cell N/A
    Rat Fcgr3a-4082R Recombinant Rat Fcgr3a, His tagged Human Cell His
    Rat Fcgr3a-6759R Recombinant Rat Fcgr3a protein, His & GST-tagged E.coli His/GST

    FCGR3A involved in several pathways and played different roles in them. We selected most pathways FCGR3A participated on our site, such as Phagosome, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome ATP6V1B2; ITGA5; HLA-DPA1; M6PR; C3A.3; ITGB3B; NCF1; FCGR2C; MHC2A; SEC61A1
    Osteoclast differentiation FOSB; LILRA5; NFATC1; SOCS1; PPP3R1; FCGR2C; MAPK13; AKT1; RAC1; IFNAR2
    Natural killer cell mediated cytotoxicity CD247; ITGB2; ITGB2L; VAV2; KIR2DS2; TNFRSF10D; SAMD3; CD244; IFNB1; NCR1
    Fc gamma R-mediated phagocytosis RAC2; AKT1; GAB2; BIN1; PIK3R3; PLA2G4D; PIK3CD; PIK3R2; WASF2; PPAP2A
    Leishmaniasis TLR4; ELK1; MAPK1; MAPK3; HLA-DQA1; ITGAM; IL12A; H2-AA; IL12B; TRAF6
    Staphylococcus aureus infection HLA-DRB1; HLA-DRA; CFH; ICAM1; FCGR3; HLA-DPA1; FPR2; PTAFR; C4A; MBL2
    Tuberculosis CD209C; CD209B; IFNA16; HSPA9; ATP6V0A4; VDR; TNF; IFNG; TLR4; HLA-DOB
    Systemic lupus erythematosus HIST1H2BN; C2; GRIN2B; SNRPB; HIST2H3A; SNRPD3; HIST1H2BH; HIST1H2BP; GM6026; FCGR3A

    FCGR3A has several biochemical functions, for example, IgG binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR3A itself. We selected most functions FCGR3A had, and list some proteins which have the same functions with FCGR3A. You can find most of the proteins on our site.

    Function Related Protein
    IgG binding FCGR1A; FCGR2B; FCGRT; FCGR1; CD247L; FCGR2C; FCGR1B; FCGR2A; PIP; UMOD

    FCGR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR3A.

    drozitumab; FCGR1A; ZBTB25; q81sn0_bacan

    Matlawska-Wasowska, K; Gale, JM; et al. Pyrosequencing for Classification of Human Fc gamma RIIIA Allotypes: A Comparison with PCR-Based Techniques. MOLECULAR DIAGNOSIS & THERAPY 18:665-673(2014).
    Chen, JY; Wang, CM; et al. Association of FCGR3A and FCGR3B Copy Number Variations With Systemic Lupus Erythematosus and Rheumatoid Arthritis in Taiwanese Patients. ARTHRITIS & RHEUMATOLOGY 66:3113-3121(2014).

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