|Official Full Name||Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)|
|Background||This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||CD 16; CD 16a; CD16A; CD16a antigen; CD16B; CD16b antigen; Fc fragment of IgG; Fc fragment of IgG low affinity IIIa receptor (CD16); Fc fragment of IgG, low affinity III, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc gamma R3; Fc gamma receptor IIIA; Fc gamma receptor IIIb (CD 16); Fc gamma RIII alpha; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIa; Fc gamma RIIIb; Fc of IgG; Fc-gamma receptor III2 (CD 16); Fc-gamma receptor III2 (CD16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG 3; FCG3; FCG3A_HUMAN; FCgammaRIIIA; FCGR 3; FCGR 3A; FCGR3; FCGR3A; FCGR3A protein; FCGRIII; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIa; IGFR 3; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III 2; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; Low affinity IIIa receptor; Low affinity immunoglobulin gamma Fc region receptor III A; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IIIB; neutrophil-specific antigen NA|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FCGR3A involved in several pathways and played different roles in them. We selected most pathways FCGR3A participated on our site, such as Phagosome, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phagosome||ATP6V1B2; ITGA5; HLA-DPA1; M6PR; C3A.3; ITGB3B; NCF1; FCGR2C; MHC2A; SEC61A1|
|Osteoclast differentiation||FOSB; LILRA5; NFATC1; SOCS1; PPP3R1; FCGR2C; MAPK13; AKT1; RAC1; IFNAR2|
|Natural killer cell mediated cytotoxicity||CD247; ITGB2; ITGB2L; VAV2; KIR2DS2; TNFRSF10D; SAMD3; CD244; IFNB1; NCR1|
|Fc gamma R-mediated phagocytosis||RAC2; AKT1; GAB2; BIN1; PIK3R3; PLA2G4D; PIK3CD; PIK3R2; WASF2; PPAP2A|
|Leishmaniasis||TLR4; ELK1; MAPK1; MAPK3; HLA-DQA1; ITGAM; IL12A; H2-AA; IL12B; TRAF6|
|Staphylococcus aureus infection||HLA-DRB1; HLA-DRA; CFH; ICAM1; FCGR3; HLA-DPA1; FPR2; PTAFR; C4A; MBL2|
|Tuberculosis||CD209C; CD209B; IFNA16; HSPA9; ATP6V0A4; VDR; TNF; IFNG; TLR4; HLA-DOB|
|Systemic lupus erythematosus||HIST1H2BN; C2; GRIN2B; SNRPB; HIST2H3A; SNRPD3; HIST1H2BH; HIST1H2BP; GM6026; FCGR3A|
FCGR3A has several biochemical functions, for example, IgG binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR3A itself. We selected most functions FCGR3A had, and list some proteins which have the same functions with FCGR3A. You can find most of the proteins on our site.
|IgG binding||FCGR1A; FCGR2B; FCGRT; FCGR1; CD247L; FCGR2C; FCGR1B; FCGR2A; PIP; UMOD|
FCGR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR3A.
drozitumab; FCGR1A; ZBTB25; q81sn0_bacan