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FCGR3A

  • Official Full Name

    Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)

  • Overview

    This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CD 16; CD 16a; CD16A; CD16a antigen; CD16B; CD16b antigen; Fc fragment of IgG; Fc fragment of IgG low affinity IIIa receptor (CD16); Fc fragment of IgG, low affinity III, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc gamma R3; Fc gamma receptor IIIA; Fc gamma receptor IIIb (CD 16); Fc gamma RIII alpha; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIa; Fc gamma RIIIb; Fc of IgG; Fc-gamma receptor III2 (CD 16); Fc-gamma receptor III2 (CD16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG 3; FCG3; FCG3A_HUMAN; FCgammaRIIIA; FCGR 3; FCGR 3A; FCGR3; FCGR3A; FCGR3A protein; FCGRIII; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIa; IGFR 3; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III 2; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; Low affinity IIIa receptor; Low affinity immunoglobulin gamma Fc region receptor III A; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IIIB; neutrophil-specific antigen NA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Rat
  • CHO
  • CHO Cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • C
  • 6×His
  • His
  • Avi
  • Fc
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • His(C
  • ter)
  • His|Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FCGR3A-2966H Active Recombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Phe Human Cell His/Avi Met1-Gln208
Human FCGR3A-309H Active Recombinant Human FCGR3A protein, His-tagged HEK293 His Met1-Gln208,F176V
Human FCGR3A-2965H Active Recombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Val Human Cell His/Avi Met1-Gln208
Human FCGR3A-626H Active Recombinant Human FCGR3A Protein, His-tagged HEK293 His
Human FCGR3A-01H Active Recombinant Human FCGR3A Protein, His-Tagged HEK293 His 197aa
Human FCGR3A-052H Active Recombinant Human FCGR3A(F176) protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Gly17-Gln208
Human FCGR3A-051H Active Recombinant Human FCGR3A protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Gly17-Gln208
Human FCGR3A-6942H Recombinant Human Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a), His-tagged E.coli His 18-208aa
Human FCGR3A-3995H Recombinant Human FCGR3A Protein Wheat Germ N/A
Human FCGR3A-625H Active Recombinant Human FCGR3A, His-tagged, 176 Phe HEK293 His
Human FCGR3A-3830H Recombinant Human FCGR3A, His & AVI tagged Human Cell His/Avi
Human FCGR3A-7287H Recombinant Human FCGR3A protein(Met1-Gln208,176F), His-tagged CHO Cells C-His Met1-Gln208,176F
Human FCGR3A-3996H Recombinant Human FCGR3A Protein, GST-tagged Wheat Germ GST
Human FCGR3A-261H Recombinant Human FCGR3A, His-tagged, Biotinylated HEK293 His
Human FCGR3A-001HCL Recombinant Human FCGR3A cell lysate CHO N/A
Human FCGR3A-1999HCL Recombinant Human FCGR3A cell lysate Human Cell N/A
Human FCGR3A-788HG Active GMP Recombinant Human FCGR3A protein HEK293 DNA sequence encoding Human CD16a (F176)(UniProtKB/Swiss-Prot: P08637.2) was expressed with His tag at the C-terminal.
Human FCGR3A-7288H Active Recombinant Human FCGR3A protein, His-tagged, 176 Val CHO Cells His Met 1-Gln 208
Human FCGR3A-100H Active Recombinant Human FCGR3A protein(Met1-Gln208,176F), His-Avi-tagged HEK293 C-His-Avi Met1-Gln208,176F
Human FCGR3A-5624H Recombinant Human FCGR3A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FCGR3A-4760HF Recombinant Full Length Human FCGR3A Protein In Vitro Cell Free System 423 amino acids
Human FCGR3A-132H Recombinant Human FCGR3A protein(NA2), His-Avi-tagged HEK293 His-Avi It contains Gly 17 - Ser 200. The CD16b NA1 differ with the CD16b NA2 in AA36, 65, 82, and 106. The CD16b NA1 form carries R36, N65, D82, and V106, while the CD16b NA2 form carries S36, S65, N82, and I106.
Human FCGR3A-142H Recombinant Human FCGR3A protein(R167) , His-Avi-tagged HEK293 His-Avi It contains Ala 36 - Ile 218 .
Human FCGR3A-71H Recombinant Human FCGR3A Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Gly17-Gln208
Human FCGR3A-4761HF Recombinant Full Length Human FCGR3A Protein, GST-tagged In Vitro Cell Free System GST 17-254 amino acids
Human FCGR3A-547H Recombinant Human FCGR3A Protein (V176) HEK293 254
Human FCGR3A-151H Recombinant Human FCGR3A Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human FCGR3A-901H Recombinant Human FCGR3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FCGR3A-4232H Active Recombinant Human FCGR3A protein(NA1), His-tagged HEK293 His Gly17-Ser200
Human FCGR3A-0910H Recombinant Human FCGR3A Protein (Ala26-Trp108), N-His tagged E.coli N-His Ala26-Trp108
Human FCGR3A-924H Recombinant Human FCGR3A Protein, His-tagged HEK293F N-His Gly17-Gln208
Human FCGR3A-1415H Active Recombinant Human FCGR3A(V176) protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gly17-Gln208
Human FCGR3A-214H Active Recombinant Human FCGR3A protein(F176), His-tagged HEK293 His Gly17-Gln208
Human FCGR3A-2457H Recombinant Human FCGR3A Protein (Thr20-Gln208), C-His-Fc tagged Mammalian cells C-His-Fc Thr20-Gln208
Human FCGR3A-02H Active Recombinant Human FCGR3A Protein (18-208aa), C-His-tagged Insect Cell C-His 18-208aa
Human FCGR3A-4109H Recombinant Human FCGR3A Protein (Met1-Gln208), C-His tagged Mammalian cells C-His Met1-Gln208
Human FCGR3A-138HFL Recombinant Full Length Human FCGR3A Protein, C-Flag-tagged Mammalian cells Flag
Human FCGR3A-135H Active Recombinant Human FCGR3A protein(V176), His-tagged HEK293 His Gly17-Gln208
Human FcgR3A-3280H Recombinant Human FcgR3A protein, His-tagged E.coli His Gly17~Gln208
Human FCGR3A-546H Recombinant Human FCGR3A Protein (F176) HEK293 254
Human FCGR3A-901H-B Recombinant Human FCGR3A Protein Pre-coupled Magnetic Beads HEK293
Human FCGR3A-1416H Active Recombinant Human FCGR3A protein(F176), His-Avi-tagged, Biotinylated HEK293 His-Avi Gly17-Gln208
Human FCGR3A-152H Recombinant Human FCGR3A Protein (Gly17-Gly206), C-6×His-tagged HEK293 C-6×His Gly17-Gly206
Human FCGR3A-2456H Recombinant Human FCGR3A Protein (Gly17-Gln208), C-His tagged Mammalian cells C-His Gly17-Gln208
Rat Fcgr3a-4082R Active Recombinant Rat Fcgr3a protein, His-tagged HEK293 His Met1-Pro200
Rat Fcgr3a-6759R Recombinant Rat Fcgr3a protein, His & GST-tagged E.coli His/GST Leu5~His241 (Accession # Q6XPU4)
Rat FCGR3A-1969RCL Recombinant Rat FCGR3A cell lysate Human Cell N/A
Rat CAB11540RM Mouse Anti-Rat CD16a Monoclonal Antibody Mouse N/A
Cynomolgus FCGR3A-246C Active Recombinant Cynomolgus FCGR3A protein, His-Avi-tagged HEK293 His-Avi Gly17-Gln208
Homo sapiens (Human) RFL16480HF Recombinant Full Length Human Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A(Fcgr3A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-254)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FCGR3A Related Articles

FCGR3A involved in several pathways and played different roles in them. We selected most pathways FCGR3A participated on our site, such as Phagosome, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeC1RA;NOX1;C3A.1;STX18;TLR4BA;CD209B;ACTB1;TAP2;TUBA1C
Osteoclast differentiationTNFRSF11A;PIK3R3;NFATC1;LILRB5;PPARG;GRB2;LILRA5;TAB2;TNF
Natural killer cell mediated cytotoxicityICAM2;PIK3R3;PTK2B;H60a;SYK;SOS1;KIR3DL2;PPP3CA;CD247
Fc gamma R-mediated phagocytosisWASL;MAPK1;SCIN;FCGR3A;PIK3R1;LIMK1;PPAP2B;PIP5K1A;HCK
LeishmaniasisTNF;HLA-DOB;NCF2;HLA-DPA1;Itgam&Itgb2;IFNGR2;MAPK13;ITGB2L;PTGS2
Staphylococcus aureus infectionH2-AA;DSG1C;HLA-DRB4;HLA-DQA2;GM5077;HLA-DRB3;C1QB;HLA-DRA;FPR1
TuberculosisCASP10;CLEC7A;Cd209g;FCGR1;cgr2b;RAB5B;FCGR2C;RFXAP;HLA-DMB
Systemic lupus erythematosusACTN3;HIST1H2BG;GM14478;HIST1H2BA;HIST1H2BI;GM14476;HLA-DPA1;HIST1H2BH;CD86

FCGR3A has several biochemical functions, for example, IgG binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR3A itself. We selected most functions FCGR3A had, and list some proteins which have the same functions with FCGR3A. You can find most of the proteins on our site.

Function Related Protein
IgG bindingFCGR3A;UMOD;FCGR2B;FCGR1;FCGR1B;CD247L;FCGR3B;FCER1G;cgr2b

FCGR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR3A.

drozitumab; FCGR1A; ZBTB25; q81sn0_bacan

Matlawska-Wasowska, K; Gale, JM; et al. Pyrosequencing for Classification of Human Fc gamma RIIIA Allotypes: A Comparison with PCR-Based Techniques. MOLECULAR DIAGNOSIS & THERAPY 18:665-673(2014).
Chen, JY; Wang, CM; et al. Association of FCGR3A and FCGR3B Copy Number Variations With Systemic Lupus Erythematosus and Rheumatoid Arthritis in Taiwanese Patients. ARTHRITIS & RHEUMATOLOGY 66:3113-3121(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does FCGR3A mediate immune cell activation and phagocytosis in response to antibody-opsonized targets? 07/29/2022

FCGR3A activates immune cells and mediates phagocytosis, aiding in the clearance of pathogens and antibody-coated targets.

What role does FCGR3A play in antibody-dependent cellular cytotoxicity, particularly in cancer immunotherapy? 03/03/2020

FCGR3A is key in antibody-dependent cellular cytotoxicity, crucial for the effectiveness of certain cancer immunotherapies.

How does genetic variation in the FCGR3A gene affect individual responses to monoclonal antibody treatments? 12/29/2018

Genetic variations in FCGR3A influence responses to monoclonal antibody treatments, affecting treatment efficacy.

What are the mechanisms by which FCGR3A regulates the balance between immune activation and tolerance? 12/06/2018

FCGR3A helps regulate the immune system's balance between activation and tolerance, preventing overactive immune responses.

How do alterations in FCGR3A expression or function affect the efficacy of vaccines? 08/12/2018

Changes in FCGR3A function or expression can influence vaccine efficacy, impacting immune system responses to vaccination.

How does FCGR3A contribute to the inflammatory response in infectious diseases? 01/25/2018

FCGR3A plays a role in the inflammatory response to infections, contributing to pathogen clearance and immune regulation.

What is the impact of FCGR3A expression on the development and severity of autoimmune diseases? 01/08/2018

FCGR3A expression impacts the development and severity of autoimmune diseases by modulating immune responses.

Customer Reviews (3)

Write a review
Reviews
12/28/2021

    Outstanding protein-protein interaction studies, boosts our experiments.

    02/04/2021

      Swift protein quantification, improves data reliability.

      11/21/2019

        Expertise in peptide synthesis, accelerates our peptide-based projects.

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