fcgr3a
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  • Official Full Name
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a)
  • Background
  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CD 16; CD 16a; CD16A; CD16a antigen; CD16B; CD16b antigen; Fc fragment of IgG; Fc fragment of IgG low affinity IIIa receptor (CD16); Fc fragment of IgG, low affinity III, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc gamma R3; Fc gamma receptor IIIA; Fc gamma receptor IIIb (CD 16); Fc gamma RIII alpha; Fc gamma RIII; Fc gamma RIII beta; Fc gamma RIIIa; Fc gamma RIIIb; Fc of IgG; Fc-gamma receptor III2 (CD 16); Fc-gamma receptor III2 (CD16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG 3; FCG3; FCG3A_HUMAN; FCgammaRIIIA; FCGR 3; FCGR 3A; FCGR3; FCGR3A; FCGR3A protein; FCGRIII; FcR 10; FcR-10; FcR10; FcRIII; FcRIIIa; IGFR 3; IGFR3; IgG Fc receptor III 1; IgG Fc receptor III 2; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; Low affinity IIIa receptor; Low affinity immunoglobulin gamma Fc region receptor III A; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IIIB; neutrophil-specific antigen NA
Cat.#:FCGR3A-7288HTag:His
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human FCGR3A protein, His-tagged, 176 Val
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Cat.#:FCGR3A-3995HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR3A Protein
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Cat.#:FCGR3A-3996HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FCGR3A Protein, GST-tagged
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Cat.#:FCGR3A-625HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A, His-tagged, 176 Phe
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Cat.#:FCGR3A-261HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A, His-tagged, Biotinylated
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Cat.#:FCGR3A-2965HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Val
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Cat.#:FCGR3A-2966HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Phe
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Cat.#:FCGR3A-309HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FCGR3A, His-tagged
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Cat.#:FCGR3A-3830HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A, His & AVI tagged
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Cat.#:FCGR3A-626HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A Protein, His-tagged
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Cat.#:FCGR3A-6942HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a), His-tagged
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Cat.#:FCGR3A-7287HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FCGR3A, His tagged
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Cat.#:Fcgr3a-4082RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fcgr3a, His tagged
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Cat.#:Fcgr3a-6759RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fcgr3a protein, His & GST-tagged
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Cat.#:FCGR3A-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FCGR3A cell lysate
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Cat.#:FCGR3A-1999HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FCGR3A cell lysate
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Cat.#:FCGR3A-1969RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FCGR3A cell lysate
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Involved Pathway

FCGR3A involved in several pathways and played different roles in them. We selected most pathways FCGR3A participated on our site, such as Phagosome, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
HLA-DRA; TUBB6; Itgam&Itgb2; TUBA8L; ATP6V1E2; FCAR; ITGA5; TUBA8L2; TUBA8L3; ATP6V1C2
Osteoclast differentiation
LILRA5; FCGR2A; LILRA2; FOSL2; PIK3CA; CAMK4; IL1R1; IKBKG; PLCG2; NCF1
Natural killer cell mediated cytotoxicity
KLRA8; PIK3CB; PPP3CA; KIR2DL1; CD247; ARAF; PPP3CC; IFNG; HLA-E; TNFRSF10A
Fc gamma R-mediated phagocytosis
PRKCE; INPP5D; PLA2G4A; CDC42; HCK; PLD2; BIN1; PLCG1; PIP5K1A; MAPK3
Leishmaniasis
ELK1; TAB2; Itgam&Itgb2; H2-AA; FCGR4; NCF2; FCGR3A; HLA-DMA; TRAF6; HLA-DPA1
Staphylococcus aureus infection
FCAR; ITGB2; HLA-DQA2; SELPLG; cgr2b; C5; DSG1C; MBL1; FPR1; HLA-DRB1
Tuberculosis
BAD; SPHK1; IFNA21; MRC2; IFNA17; IFNA1; IFNA2; MAPK9; BAX; IL1B
Systemic lupus erythematosus
FCGR3A; HIST1H4D; HIST1H4E; GM14477; SSB; HLA-DPA1; ACTN1; TROVE2; HIST1H2AD; HIST2H3C2

Protein Function

FCGR3A has several biochemical functions, for example, IgG binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR3A itself. We selected most functions FCGR3A had, and list some proteins which have the same functions with FCGR3A. You can find most of the proteins on our site.
Function
Related Protein
Function IgG binding
Related Protein FCGR3A; FCGRT; cgr2b; FCGR2B; FCGR2C; FCGR1B; FCER1G; FCGR1; FCGR3B; PIP

Interacting Protein

FCGR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR3A.
drozitumab; FCGR1A; ZBTB25; q81sn0_bacan

FCGR3A Related Articles

Matlawska-Wasowska, K; Gale, JM; et al. Pyrosequencing for Classification of Human Fc gamma RIIIA Allotypes: A Comparison with PCR-Based Techniques. MOLECULAR DIAGNOSIS & THERAPY 18:665-673(2014).
Chen, JY; Wang, CM; et al. Association of FCGR3A and FCGR3B Copy Number Variations With Systemic Lupus Erythematosus and Rheumatoid Arthritis in Taiwanese Patients. ARTHRITIS & RHEUMATOLOGY 66:3113-3121(2014).