fgf13
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  • Official Full Name
  • fibroblast growth factor 13
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5 end results in several transcript variants encoding different isoforms with different N-termini.
  • Synonyms
  • FGF13; fibroblast growth factor 13; FGF2; FHF2; fibroblast growth factor homologous factor 2; FGF 13; FGF 2; FGF-13; FGF13_HUMAN; FHF 2; FHF-2; OTTHUMP00000024143; OTTHUMP00000024144
Cat.#:FGF13-4103HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF13 Protein, GST-tagged
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Cat.#:FGF13-12863HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF13, GST-tagged
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Cat.#:FGF13-27598THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FGF13
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Cat.#:FGF13-521HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF13
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Cat.#:FGF13-8155HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF13 protein, His-tagged
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Cat.#:FGF13-5841MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGF13 Protein
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Cat.#:FGF13-2326RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGF13 Protein
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Cat.#:Fgf13-8156RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgf13 protein, His-tagged
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Cat.#:FGF13-1695RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FGF13 Protein, His-tagged
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Cat.#:FGF13-1139CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGF13
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Cat.#:FGF13-6248HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGF13 293 Cell Lysate
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Involved Pathway

FGF13 involved in several pathways and played different roles in them. We selected most pathways FGF13 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF13 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NFKB2; MAP3K14; FGF13A; PLA2G4A; PAK2B; RPS6KA5; PAK1; FGF4; CACNA1BA; TGFB1A
Ras signaling pathway
MAPK8; PLA2G2F; GNB3; PLCG1; FGFR4; FGF12; PLA2G2D; PRKACB; FIGF; LOC608458
Rap signaling pathway
ITGB3; PRKCG; FGF20; KITLG; INSR; PIK3CD; ITGB2; FPR1; P2RY1; PARD6B
PIK-Akt signaling pathway
LAMA2; COL6A6; ITGB5; PPP2R5E; THBS4; GNGT1; YWHAZ; COL27A1; IKBKG; PCK1
Regulation of actin cytoskeleton
BCAR1; ITGB4; DIAPH3; ARHGAP35; RHOA; FGF8; EZR; GNA12A; GIT1; ITGB8
Pathways in cancer
FGF17; KITLG; CXCR4; PIK3R5; WNT9A; VEGFB; HDAC2; FGF3; PDGFRB; NFKBIA
Melanoma
FGF1; FGF19; FGF18; FGF4; IGF1R; PIK3CG; CDH1; Fgf15; PDGFB; PIK3CD

Protein Function

FGF13 has several biochemical functions, for example, beta-tubulin binding, growth factor activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF13 itself. We selected most functions FGF13 had, and list some proteins which have the same functions with FGF13. You can find most of the proteins on our site.
Function
Related Protein
Function beta-tubulin binding
Related Protein TBCD; RGS2; LRPPRC; PEX14; PROL1; CCT5; MAP1S; ADNP; GABARAP; SIRT2
Function growth factor activity
Related Protein GDNF; MSTNB; PGF; CXCL12; TGFB1A; FGF1A; BMP2; FGF3; GDF5; PRL2C2
Function ion channel binding
Related Protein PACS1A; LYN; DIAPH1; KCNIP1; FXYD1; TCAP; PANX1; PIRT; PACS2; PRKCSH
Function microtubule binding
Related Protein MAP1B; FGF13; CASC1; DPYSL5A; RGS14; KIF1C; KIF14; KIF5B; REEP4; CAMSAP2A
Function protein binding
Related Protein KRTAP12-4; TPI1; CCL5; DTL; AOC3; PLAU; TBCB; CCDC22; RASSF1; PRDM13
Function protein kinase activator activity
Related Protein NKX3-1; DAXX; WNT11; GPRC5B; PRKAG2; STRADA; FGF13; MAPK8IP2; CAB39; TOM1L1
Function sodium channel regulator activity
Related Protein FXYD5; SCN2B; SGK1; NEDD4L; RANGRF; PRSS30; FXYD1; SGK2A; GPLD1; TMPRSS3

Interacting Protein

FGF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF13.
PRNP; CLEC3B; MAPK8IP2

FGF13 Related Articles

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Tyler, CR; Allan, AM; et al. Prenatal alcohol exposure alters expression of neurogenesis-related genes in an ex vivo cell culture model. ALCOHOL 48:483-492(2014).