fgf4
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  • Official Full Name
  • fibroblast growth factor 4
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
  • Synonyms
  • FGF4; fibroblast growth factor 4; heparin secretory transforming protein 1 , HSTF1; HBGF 4; HST; HST 1; human stomach cancer; transforming factor from FGF related oncogene; K FGF; kaposi sarcoma oncogene; KFGF; transforming protein KS3; FGF-4; HSTF-1; onc
Cat.#:FGF4-4113HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF4 Protein
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Cat.#:Fgf4-521MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor 4
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Cat.#:FGF4-167HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor-4
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Cat.#:FGF4-28882THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF4
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Cat.#:FGF4-5853MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGF4 Protein
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Cat.#:Fgf4-635MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf4
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Cat.#:FGF4-3190CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGF4
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Cat.#:FGF4-9173ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGF4
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Cat.#:FGF4-643CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle FGF4 protein, His & GST-tagged
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Cat.#:FGF4-023ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF4 (54 - 206aa)
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Cat.#:FGF4-681HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fibroblast Growth Factor 4
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Involved Pathway

FGF4 involved in several pathways and played different roles in them. We selected most pathways FGF4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA1D; CACNA1B; MAP4K4; ARRB2; C11orf52; RELA; CACNB4; MAP4K3; PRKACAB; Pdgfa&Pdgfb
Ras signaling pathway
KSR1; GNG11; KIT; GNB4; KRAS; RGL1; FOXO4; PAK6; FGF21; FGFR3
Rap signaling pathway
ANGPT2; FGF17; FGFR1; SIPA1L2; SIPA1L1; ITGB2; FGF19; KRIT1; RAF1; FLT4
PIK-Akt signaling pathway
ITGA8; Gh; TLR2; CD19; FGFR1; YWHAG; FGF11; IL7R; MTCP1; IL4
Regulation of actin cytoskeleton
RDX; ACTB; ARHGEF12; ARAF; PPP1CB; HRASA; ACTN2B; MAPK3; FGF13A; ITGB4
Pathways in cancer
Ar; LAMA5; MSH6; FGF12; PAX8; PIK3R3; PTEN; GSK3B; PRKACB; FAS
Melanoma
PDGFB; FGF4; PIK3CD; AKT1; FGF6; MDM2; PIK3CG; NRAS; AKT2; FGF12

Protein Function

FGF4 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF4 itself. We selected most functions FGF4 had, and list some proteins which have the same functions with FGF4. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor receptor binding
Related Protein FGF6B; FGF20B; FGF21; FGF8; FGF10; Fgf15; FRS2; FRS3; FGF2; FGF5
Function growth factor activity
Related Protein LEFTY2; MSTN; FGF1B; GDNFA; EPGN; FGF13B; BMP7; IGF2A; NDR1; LACRT
Function heparin binding
Related Protein FGF2; BSPH1; GM4980; CCL15; FGFR2; PTCH1; RPL29; ADAMTS8; BMP4; FGF4

FGF4 Related Articles

Joo, JY; Choi, HW; et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions (vol 4, pg 7477, 2014). SCIENTIFIC REPORTS 5:-(2015).
Shams, S; Mohsin, S; et al. Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice. Stem Cells International :-(2015).