Active GMP Recombinant Human FGF4 Protein
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Cat.No. : | FGF4-01HG Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human FGF4 protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines. |
Description : | Fibroblast growth factor-4 (FGF-4), also known as FGF-K or K-FGF, a heparin-binding growth factor, is a member of the FGF family. Proteins of this family play a central role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and differentiation. Mature human FGF4 shares 91%, 82%, 94%, and 91% AA properties with mouse, rat, canine, and bovine FGF4, and human FGF-4 exhibits cross-species activity. The expression of FGF-4 and its receptors, i.e. FGF R1c, 2c, 3c, and 4, is spatiotemporally regulated during embryonic development. fGF-4 has a physiologically relevant role in human embryonic stem cell self-renewal. fGF-4 not only promotes the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induces BMSCs to form hepatocyte-like cells in vitro. fGF4-induced bone marrow MSCs can promote liver regeneration through the microenvironment of transplantation. Thus, FGF4- bFGF-BMSCs can improve the survival of transplanted cells, reduce myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac function. fGF-4 promotes fibroblast and endothelial cell mitosis in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been used to treat coronary artery disease. |
Source : | CHO-K1 |
Species : | Human |
Form : | Lyophilized powder |
Endotoxin : | <20 EU/mg |
Bio-activity : | >1.0 x 10^5 IU/mg |
Purity : | >95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE. |
Storage Buffer : | 10mM Phosphate-Buffered Saline (pH 7.2) |
Storage : | Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing. |
Sterility : | Sterility |
Instructions : | It is recommended that lyophilized GMP rhFGF4 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration. |
Gene Name : | FGF4 fibroblast growth factor 4 [ Homo sapiens (human) ] |
Official Symbol : | FGF4 |
Synonyms : | HST; KFGF; FGF-4; HST-1; HSTF1; K-FGF; HBGF-4; HSTF-1 |
Gene ID : | 2249 |
mRNA Refseq : | NM_002007.4 |
Protein Refseq : | NP_001998.1 |
UniProt ID : | P08620 |
MIM : | 164980 |
◆ Recombinant Protein
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FGF4-1495H | Recombinant Human FGF4 Protein, His-tagged | +Inquiry |
FGF4-413F | Recombinant Human FGF4 Protein (177 aa) | +Inquiry |
FGF4-87H | Recombinant Human FGF4 Protein | +Inquiry |
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