FGF4-01HG
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant human FGF4 protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines.
Description :
Fibroblast growth factor-4 (FGF-4), also known as FGF-K or K-FGF, a heparin-binding growth factor, is a member of the FGF family. Proteins of this family play a central role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and differentiation. Mature human FGF4 shares 91%, 82%, 94%, and 91% AA properties with mouse, rat, canine, and bovine FGF4, and human FGF-4 exhibits cross-species activity. The expression of FGF-4 and its receptors, i.e. FGF R1c, 2c, 3c, and 4, is spatiotemporally regulated during embryonic development. fGF-4 has a physiologically relevant role in human embryonic stem cell self-renewal. fGF-4 not only promotes the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induces BMSCs to form hepatocyte-like cells in vitro. fGF4-induced bone marrow MSCs can promote liver regeneration through the microenvironment of transplantation. Thus, FGF4- bFGF-BMSCs can improve the survival of transplanted cells, reduce myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac function. fGF-4 promotes fibroblast and endothelial cell mitosis in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been used to treat coronary artery disease.
Source :
CHO-K1
Species :
Human
Form :
Lyophilized powder
Endotoxin :
<20 EU/mg
Bio-activity :
>1.0 x 10^5 IU/mg
Purity :
>95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE.
Storage Buffer :
10mM Phosphate-Buffered Saline (pH 7.2)
Storage :
Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing.
Sterility :
Sterility
Instructions :
It is recommended that lyophilized GMP rhFGF4 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.