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FKBP3

  • Official Full Name

    FK506 binding protein 3, 25kDa

  • Overview

    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
  • Synonyms

    FKBP3; FK506 binding protein 3, 25kDa; FK506 binding protein 3 (25kD); peptidyl-prolyl cis-trans isomerase FKBP3; FKBP 25; PPIase; FKBP 3; FKBP25; Rotamase; 25 kDa FKBP; PPIase FKBP3; OTTHUMP00000178918; immunophilin FKBP25; rapamycin binding protein; 25 kDa FK506-binding protein; FK506-binding protein 3 (25kD); FK506-binding protein 25, T-cell; rapamycin-selective 2; FKBP-3; FKBP-25;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dictyostelium discoideum (Slime mold)
  • Human
  • Mouse
  • Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FKBP3-373H Recombinant Human FKBP3 Mammalian Cell His
Human FKBP3-2026H Recombinant Human FK506 Binding Protein 3, 25kDa E.coli N/A
Human FKBP3-6936H Recombinant Human FKBP3, GST tagged E.coli GST
Human FKBP3-28915TH Recombinant Human FKBP3 E.coli N/A
Human FKBP3-12912H Recombinant Human FKBP3, GST-tagged E.coli GST 1-224a.a.
Human FKBP3-28917TH Recombinant Human FKBP3, His-tagged E.coli His
Human FKBP3-795H Recombinant Human FKBP3 Protein, His-tagged E.coli His
Human FKBP3-6206HCL Recombinant Human FKBP3 293 Cell Lysate HEK293 N/A
Human FKBP3-4190H Recombinant Human FKBP3 Protein, GST-tagged Wheat Germ GST
Human FKBP3-4804HF Recombinant Full Length Human FKBP3 Protein, GST-tagged In Vitro Cell Free System GST 224 amino acids
Human FKBP3-2954H-B Recombinant Human FKBP3 Protein Pre-coupled Magnetic Beads HEK293
Human FKBP3-2921H Recombinant Human FKBP3 protein, His-SUMO-tagged E.coli His-SUMO 2-224aa
Human FKBP3-3024H Recombinant Human FKBP3 Protein (Met1-Asp224), N-His tagged E.coli N-His Met1-Asp224
Human FKBP3-2954H Recombinant Human FKBP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fkbp3-1266M Recombinant Mouse Fkbp3 protein, His-tagged E.coli His Ala2~Asp224 (Accession # Q62446)
Mouse Fkbp3-3026M Recombinant Mouse Fkbp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cattle FKBP3-2188C Recombinant Cattle FKBP3 Protein, His-tagged E.coli N-His Ala2-Asp224
Dictyostelium discoideum (Slime mold) RFL26959DF Recombinant Full Length Dictyostelium Discoideum Fk506-Binding Protein 3(Fkbp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-194)
Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) RFL36981RF Recombinant Full Length Rhizopus Oryzae Fk506-Binding Protein 2B(Fkbp3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-209)
Zebrafish FKBP3-1251Z Recombinant Zebrafish FKBP3 Mammalian Cell His
Chicken FKBP3-6209C Recombinant Chicken FKBP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FKBP3 Related Research Area

FKBP3 involved in several pathways and played different roles in them. We selected most pathways FKBP3 participated on our site, such as Integrated Pancreatic Cancer Pathway, Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Pancreatic Cancer PathwayTFF1;CASP12;TOP2A;MAPK4;WRN;IL11;CST3;FST;DAXX
Signaling events mediated by HDAC Class IGATA1;MXD1;SIRT2;GATA2;SIRT5;SIRT4;SIRT7;FKBP3;NR2C1

FKBP3 has several biochemical functions, for example, FK506 binding, peptidyl-prolyl cis-trans isomerase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP3 itself. We selected most functions FKBP3 had, and list some proteins which have the same functions with FKBP3. You can find most of the proteins on our site.

Function Related Protein
FK506 bindingNFATC1;FKBP2;FKBP1B;FKBP9;FKBP8;FKBP4;FKBP1AA;FKBP10;FKBP3
peptidyl-prolyl cis-trans isomerase activityTTC9B;PPIFB;PPIL1;FKBP1A;PPIFA;PPIE;PPIL6;FKBP2;PPP2R4
poly(A) RNA bindingRRP9;PABPC4;Cstb;GTPBP4;TRMT2A;RPL22;PRMT1;SRSF1;QKI
protein bindingSTAT5A;CPSF2;IGFLR1;CST5;MYH10;MAPK14;SOCS1;THOC4;FSTL5
receptor activityAMFR;CSF2RB;HTR3A;SIGLEC7;P2RY2;CADM2;FAS;CD40;OGFRL2

FKBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP3.

PARP2; MDM2; SRPK1; MCC; HLA-B; TNIK

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