fkbp3
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  • Official Full Name
  • FK506 binding protein 3, 25kDa
  • Background
  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
  • Synonyms
  • FKBP3; FK506 binding protein 3, 25kDa; FK506 binding protein 3 (25kD); peptidyl-prolyl cis-trans isomerase FKBP3; FKBP 25; PPIase; FKBP 3; FKBP25; Rotamase; 25 kDa FKBP; PPIase FKBP3; OTTHUMP00000178918; immunophilin FKBP25; rapamycin binding protein; 25 kDa FK506-binding protein; FK506-binding protein 3 (25kD); FK506-binding protein 25, T-cell; rapamycin-selective 2; FKBP-3; FKBP-25
Cat.#:FKBP3-4190HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FKBP3 Protein, GST-tagged
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Cat.#:FKBP3-12912HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP3, GST-tagged
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Cat.#:FKBP3-28915THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP3
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Cat.#:FKBP3-28917THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP3, His-tagged
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Cat.#:FKBP3-373HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FKBP3
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Cat.#:FKBP3-6936HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP3, GST tagged
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Cat.#:FKBP3-795HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP3 Protein, His-tagged
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Cat.#:Fkbp3-1266MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fkbp3 protein, His-tagged
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Cat.#:FKBP3-6209CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FKBP3
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Cat.#:FKBP3-1251ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FKBP3
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Cat.#:FKBP3-2026HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FK506 Binding Protein 3, 25kDa
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Cat.#:FKBP3-6206HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FKBP3 293 Cell Lysate
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Involved Pathway

FKBP3 involved in several pathways and played different roles in them. We selected most pathways FKBP3 participated on our site, such as Integrated Pancreatic Cancer Pathway, Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Integrated Pancreatic Cancer Pathway
CD82; TFF1; RAPGEF3; IL11; NOXA1; MAPK4; RB1CC1; AGA; JUND; WRN
Signaling events mediated by HDAC Class I
WDR77; SIRT5; SIRT4; GATA2; FKBP3; PRMT5; SIRT2; GATA1; NR2C1; MXD1

Protein Function

FKBP3 has several biochemical functions, for example, FK506 binding, peptidyl-prolyl cis-trans isomerase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP3 itself. We selected most functions FKBP3 had, and list some proteins which have the same functions with FKBP3. You can find most of the proteins on our site.
Function
Related Protein
Function FK506 binding
Related Protein FKBP1A; FKBP1AB; FKBP1B; FKBP9; FKBP8; FKBP4; FKBP1AA; FKBP2; TTC9B; FKBP3
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PPIFB; RANBP2; PPIH; TTC9C; TTC9B; FKBPL; PPIF; FKBP8; PPIG; PPWD1
Function poly(A) RNA binding
Related Protein CTNNA1; RPL30; DNM1; SMC1A; PELP1; FAM120B; IPO5; NCOA5; NOP16; RPS28
Function protein binding
Related Protein PITPNM1; TOE1; CDK2; JAM3; HMGB4; CCDC60; GRN; FUZ; ADH1A; ASPA
Function receptor activity
Related Protein CD4; VMN1R52; RAMP1; PAQR5B; NOTCH1; ANTXR2; PVRL4; IGF2R; SMAGP; UNC13B

Interacting Protein

FKBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP3.
PARP2; MDM2; SRPK1; MCC; HLA-B; TNIK