fyn
Share
  • Official Full Name
  • FYN oncogene related to SRC, FGR, YES
  • Background
  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.
  • Synonyms
  • FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; src-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; src/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regu
Cat.#:FYN-4585HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FYN Protein, GST/His-tagged
+Inquiry
Cat.#:FYN-4586HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FYN Protein, GST-tagged
+Inquiry
Cat.#:FYN-2128HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged
+Inquiry
Cat.#:FYN-1766HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN protein, His & T7-tagged
+Inquiry
Cat.#:FYN-217HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN Oncogene Related To SRC, FGR, YES
+Inquiry
Cat.#:FYN-2410HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FYN, GST-tagged
+Inquiry
Cat.#:FYN-28958THTag:
Source (Host):Species:Human
Product nameRecombinant Human FYN
+Inquiry
Cat.#:FYN-322HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FYN, GST-tagged, Active
+Inquiry
Cat.#:FYN-50HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FYN protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:FYN-6112MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FYN Protein
+Inquiry
Cat.#:FYN-2427RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FYN Protein
+Inquiry
Cat.#:FYN-6901CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FYN
+Inquiry
Cat.#:FYN-6091HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FYN 293 Cell Lysate
+Inquiry

Involved Pathway

FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway, Phospholipase D signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
RELA; CERS5; SPTLC2; PPP2R3C; TRP53; GNAI2; KRAS; SPHK2; GAB2; SPHK1
Phospholipase D signaling pathway
AGPAT4; AKT2; PDGFD; PDGFRB; PLA2G4C; AGPAT3; CYTH3; TSC2; LPAR5; PIK3CG
Axon guidance
MYL12A; DPYSL4; PTK2; MET; CSNK2A2; NRG3; PEA15; SEMA5B; DPYSL3; NRAS
Osteoclast differentiation
LILRA5; CYBA; MAP2K7; TREM2; SFPI1; STAT2; TGFB2; MAPK1; BTK; PIK3CA
Focal adhesion
PDGFC; VEGFA; XIAP; PIK3CA; ITGA4; MYL9; CAV3; ITGB1A; DIAP1; MYL5
Adherens junction
WASLA; EGFR; ACTN2; RAC1; SSX2IP; ACTB2; NLK2; LEF1; SMAD3; FYN
Platelet activation
PRKACG; ROCK2; PLA2G4D; PTGIR; GP1BB; GNAI3; RAP1B; TLN1; ITGB1; PPP1R12A
Natural killer cell mediated cytotoxicity
SHC4; PRKCA; TYROBP; FCER1G; VAV1; PIK3CD; Fasl; IFNA10; GZMB; PRF1
T cell receptor signaling pathway
CD4; CD3G; PIK3R1; PIK3CD; GSK3B; FYN; LCP2; CARD11; TNF; EVLB
Fc epsilon RI signaling pathway
MAP2K2; SOS1; PLA2G4F; PIK3CG; MAPK11; PLA2G4A; TNF; MAPK12; KRAS; RAC2
Cholinergic synapse
CHRNA6; CREB5; KCNJ2; CAMK2D; GNAI2; PRKCB; CHRM4; PRKACG; KCNJ6; GNG4
Prion diseases
SOD1; HSPA1A; Hc; C1QC; PRKACG; C8G; NCAM1; C1QB; LOC100033925; IL1B
Pathogenic Escherichia coli infection
TUBAL3; TUBA1B; TUBA3C; EZR; CLDN1; TUBA1C; ARHGEF2; ROCK2; NCK2; YWHAZ
Measles
RCHY1; STAT5B; IRF3; IFNA8; PIK3CB; Ifna15; DDX58; TNFRSF10B; TACR1; MAP3K7
Viral myocarditis
CD40LG; ABL2; ITGB2L; CCND1; HLA-DRB5; HLA-DQA1; HLA-B; SGCA; HLA-DRA; H2-AB1

Protein Function

FYN has several biochemical functions, for example, ATP binding, CD4 receptor binding, CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PMS1; PIP5KL1; DHX9; ATP1A1A.5; ACTBL2; ULK2; CMPK2; ATP2A2; CHORDC1; UBA6
Function CD4 receptor binding
Related Protein LCK; FYN; PLSCR1; PLSCR4; SPG21
Function CD8 receptor binding
Related Protein LCK; FYN
Function G-protein coupled receptor binding
Related Protein UCN2; HAND2; AKAP5; GNAT3; GPRC5B; RSPO3; GNA15.4; GNAI2; QRFP; SFTPBB
Function T cell receptor binding
Related Protein FYN; EPS8L1; HLA-A; CD3E; H2-Q10; DOCK2; CD1d1; CD3G
Function ephrin receptor binding
Related Protein EFNA5B; CDK5; EFNB3B; EFNA4; Anks1; EFNB3; PTPN1; EFNB2A; SRC; CHN1
Function glycoprotein binding
Related Protein SHB; F7; TFR2; ERLEC1; FBXO2; CNTN2; CALR; CDH1; FGFR1; Itgam&Itgb2
Function growth factor receptor binding
Related Protein SLC9A3R1; APP; SRC; FYN
Function ion channel binding
Related Protein NEDD4L; PKD2; PACS1; TCAP; SRC; VDAC1; RYR2; SNTA1; KCNC1; DIAP1
Function metal ion binding
Related Protein MOB3C; RUFY2; PPEF2; HCCS; ATP1A1A.5; ZFP346; ZNF396; SOBP; APTX; TPH1B
Function non-membrane spanning protein tyrosine kinase activity
Related Protein HCK; ITK; FYNA; LYN; SRMS; PTK6B; TEC; SRC; PTK2B; STK16
Function peptide hormone receptor binding
Related Protein ADCYAP1; PTHLH; PTHLHA; JAK2; FYN; PTPN11; LEP; RUNDC3A; PTH; NPPA
Function phosphatidylinositol 3-kinase binding
Related Protein INSRB; IRS4; CORO1A; INSRR; PIK3R1; ATP1A1; INSR; HCST; CALM3; TYRO3
Function protein binding
Related Protein TTC25; FAM156A; ATL2; PTPRO; GRIA1; UACA; IGHMBP2; GSPT2; EXOSC5; NTM
Function protein tyrosine kinase activity
Related Protein EGFRA; FGFR1B; CLK2; FGFR4; EK1; PTK7; TESK1; DYRK1A; BMX; FGFR1OP
Function tubulin binding
Related Protein EML1; MTAP4; CENPJ; RITA1; MTAP7D3; AGTPBP1; RABGAP1; STMN2; STMN2A; TBCC

Interacting Protein

FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.
FYB; CBL; PRKCD; KHDRBS1

FYN Related Articles

Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

FYN Related Gene Family

TGF