g6pc
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  • Official Full Name
  • glucose-6-phosphatase, catalytic subunit
  • Background
  • Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
  • Synonyms
  • G6PC; glucose-6-phosphatase, catalytic subunit; G6PT, glucose 6 phosphatase, catalytic (glycogen storage disease type I, von Gierke disease); glucose-6-phosphatase; glycogen storage disease type I; von Gierke disease; GSD1a; GSD1; AW107337; G-6-Pase; G6Pase; G6Pase-alpha; G6PC_HUMAN; G6PT; Glucose-6-phosphatase alpha; MGC163350; MGC93613; RP23-281C18.19; G6PC1
Cat.#:G6PC-4613HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human G6PC Protein, GST-tagged
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Cat.#:G6PC-27523THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human G6PC
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Cat.#:G6PC-6129MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse G6PC Protein
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Cat.#:G6PC-2435RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat G6PC Protein
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Cat.#:G6PC-6082HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human G6PC 293 Cell Lysate
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Involved Pathway

G6PC involved in several pathways and played different roles in them. We selected most pathways G6PC participated on our site, such as Glycolysis / Gluconeogenesis, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
ALDH2.1; TPI1; PFKM; PDHA1B; LDHBA; ALDOAA; PGAM1B; GM5506; GALM; TPI1B
Galactose metabolism
PFKMA; PFKM; PGM2; AKR1B1L; UGP2B; PGM1; GALT; AKR1B10; B4GALT1; HKDC1
Starch and sucrose metabolism
HKDC1; UGT1A2; UGT2A3; GBA3; PYGM; PGM2L1; UGT2B15; PYGL; UGT1A6A; G6PC3
Metabolic pathways
CYP17A1; GCNT4; ADH2-2; HSD17B6; PLA2G2A; GALNTL2; PPAP2D; TWISTNB; PAPSS2A; HYI
FoxO signaling pathway
MAPK12A; PRKAA1; G6PC; MAP2K2B; PIK3CB; TNFSF10; INSRA; HOMER1; PLK3; AGAP2
PIK-Akt signaling pathway
CREB3L2; IGF1; MET; ITGA1; IL3; VWF; PDGFC; INS1; TLR4; FGF6
AMPK signaling pathway
PPP2R2D; PRKAG2; PPP2R1B; PPP2R5B; CREB5; CD36; EIF4EBP1; IRS4; SCD; PRKAB1
Insulin signaling pathway
PRKAB1A; PPARGC1A; PPP1CBL; FBP1A; SHC1; MTOR; SHC4; HRASA; LIPE; FLOT1B
Adipocytokine signaling pathway
MTOR; PTPN11B; NFKBIA; PRKAB1B; MAPK9; SLC2A4; G6PC3; PPARGC1A; NFKB1; CD36
Glucagon signaling pathway
PFKFB1; G6PC3; PRKAG2; PPARA; PPP3R2; GYS1; CALM2; PHKG1; PGAM2; PKM
Insulin resistance
RPS6KA3B; PPP1R3DA; GSK3B; SLC2A2; PPP1R3CA; NR1H2; TNF; PPP1CBL; CRTC2; INSRA
Carbohydrate digestion and absorption
AMY2A; ATP1A1; PIK3R2; PIK3R5; HK1; SLC2A5; ATP1A2; GNAT3; PIK3CD; AMY1B

Protein Function

G6PC has several biochemical functions, for example, glucose-6-phosphatase activity, phosphate ion binding, phosphotransferase activity, alcohol group as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PC itself. We selected most functions G6PC had, and list some proteins which have the same functions with G6PC. You can find most of the proteins on our site.
Function
Related Protein
Function glucose-6-phosphatase activity
Related Protein G6PCA.2; G6PC3; G6PC; G6PCA.1; G6PC2
Function phosphate ion binding
Related Protein SLC34A2; ADSS; RPH3A; SH2B3; CHST14; RELA; PNP; OTC; ADSSL1; GNG12
Function phosphotransferase activity, alcohol group as acceptor
Related Protein PI4KAA; ADKB; SGK196; POMK; FAM20B; GKUP; PI4KAB; PI4KAP2; G6PC; FGGY

Interacting Protein

G6PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PC here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PC.
CDH16; NSL1; SNX13

G6PC Related Articles

Zhou, YL; Wei, XH; et al. Potassium diformate influences gene expression of GH/IGF-I axis and glucose homeostasis in weaning piglets. LIVESTOCK SCIENCE 172:85-90(2015).
Zheng, BX; Lin, Q; et al. Three novel mutations of the G6PC gene identified in Chinese patients with glycogen storage disease type Ia. EUROPEAN JOURNAL OF PEDIATRICS 174:59-63(2015).