G6PC Protein, glucose-6-phosphatase, catalytic subunit


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Official Full Name glucose-6-phosphatase, catalytic subunit
Background Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
Synonyms G6PC; glucose-6-phosphatase, catalytic subunit; G6PT, glucose 6 phosphatase, catalytic (glycogen storage disease type I, von Gierke disease); glucose-6-phosphatase; glycogen storage disease type I; von Gierke disease; GSD1a; GSD1; AW107337; G-6-Pase; G6Pase; G6Pase-alpha; G6PC_HUMAN; G6PT; Glucose-6-phosphatase alpha; MGC163350; MGC93613; RP23-281C18.19; G6PC1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human G6PC-27523TH Recombinant Human G6PC Wheat Germ N/A
    Human G6PC-4613H Recombinant Human G6PC Protein, GST-tagged Wheat Germ GST
    Human G6PC-6082HCL Recombinant Human G6PC 293 Cell Lysate HEK293 N/A
    Mouse G6PC-6129M Recombinant Mouse G6PC Protein Mammalian Cell His
    Rat G6PC-2435R Recombinant Rat G6PC Protein Mammalian Cell His

    G6PC involved in several pathways and played different roles in them. We selected most pathways G6PC participated on our site, such as Glycolysis / Gluconeogenesis, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis ACSS1; ADH7; PCK2; GPIA; AKR1A1; ADH2-1; PDHA2; MINPP1; ALDOCB; ALDH2.1
    Galactose metabolism HK3; B4GALT2; LCT; AKR1B1; B4GALT1; G6PCA.1; PGM1; GAA; PFKMB; LALBA
    Starch and sucrose metabolism UGT1A3; G6PC2; Amy1; AMY2A3; UGP2; GPIB; UGT1A4; UGT1A2; GBA3; PYGL
    Metabolic pathways POLR3H; GBE1; DHRS3; TM7SF2; ALPI; MTMR1A; ST6GALNAC4; SDHA; GKUP; GLULB
    FoxO signaling pathway BNIP3; INSRA; MAPK12A; AKT3A; G6PC; CCND2A; PRKAB2; GADD45B; CDKN1BA; PRKAG1
    PIK-Akt signaling pathway PRLR; ANGPT4; PIK3CG; BAD; IL6R; IL7; ITGB4; MTOR; DDIT4; PPP2R5D
    AMPK signaling pathway PPP2R3C; TSC2; CPT1B; PPP2R5A; PRKAG3; IGF1R; HNF4A; INS; MTOR; ULK1
    Insulin signaling pathway PRKAA2; GYS1; MAP2K2; SLC2A4; RAPGEF1; RAPGEF1B; PIK3R3; INPPL1A; MAP2K2A; PDPK1
    Adipocytokine signaling pathway CPT1C; PRKAG3; LEP; RXRBA; SOCS3B; JAK2B; ACSL3B; LEPB; PCK2; SLC2A4
    Glucagon signaling pathway SMEK1; PPP3R1; PRKAB2; LDHAL6B; G6PC3; SIK2; CALML3; PRKAA2; AKT2; PDHA2
    Insulin resistance INS; RPS6KA2; PRKAB1; PRKCZ; PPARGC1B; SLC2A1A; PRKCB; G6PC; RELA; RPS6KA3
    Carbohydrate digestion and absorption ATP1B2; AMY2A2; AMY2A; AMY2A3; AMY2A5; AMY1A; PRKCB; PIK3CA; ATP1A4; PIK3CG

    G6PC has several biochemical functions, for example, glucose-6-phosphatase activity, phosphate ion binding, phosphotransferase activity, alcohol group as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PC itself. We selected most functions G6PC had, and list some proteins which have the same functions with G6PC. You can find most of the proteins on our site.

    Function Related Protein
    glucose-6-phosphatase activity G6PCA.1; G6PC3; G6PCA.2; G6PC; G6PC2
    phosphate ion binding GNG12; ADSS; SLC34A2; RELA; G6PC; RPH3A; ADSSL1; CHST14; OTC; SH2B3
    phosphotransferase activity, alcohol group as acceptor PI4KAP2; G6PC; POMK; PI4KAA; FAM20B; PI4KAB; SMG1; GKUP; FGGY; ADKB

    G6PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PC here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PC.

    CDH16; NSL1; SNX13

    Zhou, YL; Wei, XH; et al. Potassium diformate influences gene expression of GH/IGF-I axis and glucose homeostasis in weaning piglets. LIVESTOCK SCIENCE 172:85-90(2015).
    Zheng, BX; Lin, Q; et al. Three novel mutations of the G6PC gene identified in Chinese patients with glycogen storage disease type Ia. EUROPEAN JOURNAL OF PEDIATRICS 174:59-63(2015).

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