|Official Full Name||glucose-6-phosphatase, catalytic subunit|
|Background||Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.|
|Synonyms||G6PC; glucose-6-phosphatase, catalytic subunit; G6PT, glucose 6 phosphatase, catalytic (glycogen storage disease type I, von Gierke disease); glucose-6-phosphatase; glycogen storage disease type I; von Gierke disease; GSD1a; GSD1; AW107337; G-6-Pase; G6Pase; G6Pase-alpha; G6PC_HUMAN; G6PT; Glucose-6-phosphatase alpha; MGC163350; MGC93613; RP23-281C18.19; G6PC1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
G6PC involved in several pathways and played different roles in them. We selected most pathways G6PC participated on our site, such as Glycolysis / Gluconeogenesis, Galactose metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycolysis / Gluconeogenesis||ACSS1; ADH7; PCK2; GPIA; AKR1A1; ADH2-1; PDHA2; MINPP1; ALDOCB; ALDH2.1|
|Galactose metabolism||HK3; B4GALT2; LCT; AKR1B1; B4GALT1; G6PCA.1; PGM1; GAA; PFKMB; LALBA|
|Starch and sucrose metabolism||UGT1A3; G6PC2; Amy1; AMY2A3; UGP2; GPIB; UGT1A4; UGT1A2; GBA3; PYGL|
|Metabolic pathways||POLR3H; GBE1; DHRS3; TM7SF2; ALPI; MTMR1A; ST6GALNAC4; SDHA; GKUP; GLULB|
|FoxO signaling pathway||BNIP3; INSRA; MAPK12A; AKT3A; G6PC; CCND2A; PRKAB2; GADD45B; CDKN1BA; PRKAG1|
|PIK-Akt signaling pathway||PRLR; ANGPT4; PIK3CG; BAD; IL6R; IL7; ITGB4; MTOR; DDIT4; PPP2R5D|
|AMPK signaling pathway||PPP2R3C; TSC2; CPT1B; PPP2R5A; PRKAG3; IGF1R; HNF4A; INS; MTOR; ULK1|
|Insulin signaling pathway||PRKAA2; GYS1; MAP2K2; SLC2A4; RAPGEF1; RAPGEF1B; PIK3R3; INPPL1A; MAP2K2A; PDPK1|
|Adipocytokine signaling pathway||CPT1C; PRKAG3; LEP; RXRBA; SOCS3B; JAK2B; ACSL3B; LEPB; PCK2; SLC2A4|
|Glucagon signaling pathway||SMEK1; PPP3R1; PRKAB2; LDHAL6B; G6PC3; SIK2; CALML3; PRKAA2; AKT2; PDHA2|
|Insulin resistance||INS; RPS6KA2; PRKAB1; PRKCZ; PPARGC1B; SLC2A1A; PRKCB; G6PC; RELA; RPS6KA3|
|Carbohydrate digestion and absorption||ATP1B2; AMY2A2; AMY2A; AMY2A3; AMY2A5; AMY1A; PRKCB; PIK3CA; ATP1A4; PIK3CG|
G6PC has several biochemical functions, for example, glucose-6-phosphatase activity, phosphate ion binding, phosphotransferase activity, alcohol group as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PC itself. We selected most functions G6PC had, and list some proteins which have the same functions with G6PC. You can find most of the proteins on our site.
|glucose-6-phosphatase activity||G6PCA.1; G6PC3; G6PCA.2; G6PC; G6PC2|
|phosphate ion binding||GNG12; ADSS; SLC34A2; RELA; G6PC; RPH3A; ADSSL1; CHST14; OTC; SH2B3|
|phosphotransferase activity, alcohol group as acceptor||PI4KAP2; G6PC; POMK; PI4KAA; FAM20B; PI4KAB; SMG1; GKUP; FGGY; ADKB|
G6PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PC here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PC.
CDH16; NSL1; SNX13