gaa
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  • Official Full Name
  • glucosidase, alpha; acid
  • Background
  • This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompes disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • GAA; glucosidase, alpha; acid; lysosomal alpha-glucosidase; glycogen storage disease type II; Pompe disease; 70 kDa lysosomal alpha-glucosidase; Acid alpha glucosidase; Acid maltase; Aglucosidase alfa; Alpha glucosidase; Glucosidase alpha acid (Pompe disease glycogen storage disease type II); Glucosidase alpha acid; Glucosidase alpha; LYAG; LYAG_HUMAN; Lysosomal alpha glucosidase
Cat.#:GAA-002HTag:His
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human Acid α-glucosidase (GAA)
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Cat.#:GAA-159HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAA Protein, His-tagged
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Cat.#:GAA-160HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAA Protein, His-tagged
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Cat.#:GAA-173HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAA protein, His-tagged
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Cat.#:GAA-175HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAA protein, MYC/DDK-tagged
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Cat.#:GAA-176HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAA protein, MYC/DDK-tagged
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Cat.#:GAA-177HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GAA protein, MYC/DDK-tagged
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Cat.#:GAA-28087THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GAA
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Cat.#:GAA-28090THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GAA protein, GST-tagged
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Cat.#:Gaa-161MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gaa Protein, His-tagged
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Cat.#:Gaa-162MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gaa Protein, His-tagged
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Cat.#:Gaa-163RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gaa Protein, His-tagged
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Cat.#:Gaa-164RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gaa Protein, His-tagged
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Cat.#:GAA-2438RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GAA Protein
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Cat.#:GAA-6077HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAA 293 Cell Lysate
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Cat.#:Kit-0353Tag:
Source (Host):Species:
Product nameGAA Activity Colorimetric Assay Kit
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Cat.#:GAA-P026HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GAA therapeutic protein
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Involved Pathway

GAA involved in several pathways and played different roles in them. We selected most pathways GAA participated on our site, such as Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Galactose metabolism
GALK1; Akr1b3; HK2; LCT; GAA; GALM; GALT; AKR1B1; AKR1B7; GLA
Starch and sucrose metabolism
GANC; UGT1A2; UXS1; UGT1A9; AMY2B; TREH; PYGM; UGDH; AMY2A2; GAA
Metabolic pathways
DHRS4; Acsm2a; PNLIPRP2; PPAT; GCH1; RPIA; POLR2K; CBS; HSD3B2; EXTL3
Lysosome
AP3D1; LAMP1; ACP5; AP4E1; AP3M1; ATP6V0CB; Ctsl; CTSBB; FAM49BA; ARSA

Interacting Protein

GAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAA here. Most of them are supplied by our site. Hope this information will be useful for your research of GAA.
HIVEP1; STAT2; EP300; ypiP; q9wmx2-pro_0000037548; NUMBL; pi3p; cona_canen

GAA Related Articles

Lukas, J; Pockrandt, AM; et al. Enzyme Enhancers for the Treatment of Fabry and Pompe Disease. MOLECULAR THERAPY 23:456-464(2015).
Guo, MH; Hundseth, K; et al. A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase. JOURNAL OF BIOLOGICAL CHEMISTRY 290:5174-5189(2015).