GATA3 Protein, GATA binding protein 3

GATA3

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GATA3

Official Full Name GATA binding protein 3
Background This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Synonyms GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA3-28477TH Recombinant Human GATA3 Wheat Germ N/A
    Human GATA3-2939H Recombinant Human GATA3 protein, GST-tagged E.coli GST
    Human GATA3-2940H Recombinant Human GATA3 protein, His-tagged E.coli His
    Human GATA3-2941H Recombinant Human GATA3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GATA3-4747H Recombinant Human GATA3 Protein, GST-tagged Wheat Germ GST
    Human GATA3-6011HCL Recombinant Human GATA3 293 Cell Lysate HEK293 N/A
    Mouse GATA3-6224M Recombinant Mouse GATA3 Protein Mammalian Cell His
    Chicken GATA3-1825C Recombinant Chicken GATA3 Mammalian Cell His
    Zebrafish GATA3-8812Z Recombinant Zebrafish GATA3 Mammalian Cell His

    GATA3 involved in several pathways and played different roles in them. We selected most pathways GATA3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory bowel disease (IBD) TGFB1; IL2RG; HLA-DOB; STAT6; STAT1; RELA; TGFB3; NFKB1; IL22; IFNGR2

    GATA3 has several biochemical functions, for example, DNA binding, E-box binding, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA3 itself. We selected most functions GATA3 had, and list some proteins which have the same functions with GATA3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ASCL1A; MYCLA; TCF15; HIST1H2BK; ZBTB8B; ZNF136; CDC5L; ZNF488; RHOXF1; CSDC2
    E-box binding NEUROD2; ASCL1; MYOD1; MYOG; BHLHE40; NEUROG1; ZEB1; NEUROD1; ARNTL2; SREBF2
    HMG box domain binding PAX3; JUN; MEOX1; DLX5; OLIG2; SP1; PRRX1; ALX4; HOXA3; POU3F3
    RNA polymerase II core promoter sequence-specific DNA binding YAP1; RUVBL2; GATA3; GATA6; RUNX2; SOX11; TBR1; EP300; ZNF335; SOX3
    RNA polymerase II regulatory region sequence-specific DNA binding PLAGL1; BARHL1B; FOXD3; BARHL2; ZIK1; BCL6; BARX2; NR1I2; KLF12; EGR1
    RNA polymerase II transcription factor binding MKX; SPI1; PITX2; TBX3; HCLS1; CHST13; GATA2; MIXL1; GFI1B; TOX2
    chromatin binding HIST2H3C1; SMC1AL; STAG2; TCF7; BAHD1; SLC30A9; HDAC7A; GLI1; CAMTA2; RBPJ
    core promoter proximal region sequence-specific DNA binding UHRF1; CREBBP; CXXC1; DMRTC2; KLF4; DMRT1; DMRTC1C2; MIXL1; PAX2; DMRTA1
    core promoter sequence-specific DNA binding MTA1; PDX1; MYOCD; CREM; ZFHX3; ZFP750; TOP1; C1orf51; ZNF750; SOHLH1
    enhancer sequence-specific DNA binding ISL1; KLF7B; ATF2; MYT1; LDB1; TWIST1B; TBX19; SOX11; GATA5; GATA2
    interleukin-2 receptor binding IL21; TIMM50; ECM1; Il2; GATA3
    nucleic acid binding transcription factor activity GATA3; SOX4
    protein binding RAB39A; SLA2; SIAH2; TXNDC9; KRT6A; LINC01588; RNF19B; ZCCHC10; HUWE1; PSMA4
    protein dimerization activity BHLHE41; FIGLA; MEF2B; TFAP2B; SOHLH1; MESPBA; AHR1A; CELSR1; MYC; ZBED6
    transcription coactivator activity JUND; ECD; KAT6A; SUB1; NR2C2; TAF5L; TBPL1; Ankar; SMARCE1; FHL5
    transcription factor activity, sequence-specific DNA binding CDX1B; GATA2A; ZNF83; MYRFL; LMO4; ATF7; FOXO4; ARID4A; ZHX1; HSF5
    transcription factor binding ESR1; SMAD3; CEBPB; E2F5; CEBPG; PITX2; DDIT3; TRIB2; NFATC3; TRIM6
    transcription regulatory region DNA binding ZNF567; CREB3L1; GRHL2B; TAF7L; IKZF1; FOXI1; FOS; MEF2C; FOXA2; SALL1
    transcription regulatory region sequence-specific DNA binding ZNF658; POU5F1; ATF3; NKX3-1; PER2; NR5A1A; MEF2CA; NFE2L3; NONO; NFE2L2A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ETV2; PHOX2B; MEOX1; MYOCD; HOXD13; NR5A2; MIXL1; FOXC2; TFAP2B; MEF2B
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MYOCD; ESRRG; MAFA; ATF5; SRF; IKZF3; CSRNP1; MAFGB; GATA1; CEBPA
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NFIL3-6; BCL11AB; HELT; DLX4; NR1D1; SP3; BCL11AA; PROX2; TGIF1; NFATC2
    zinc ion binding APOBEC2; MMP14; TRIM40; PHEX; DNLZ; PNMA3; TAF3; LIMK2; NR2C2; UBR7

    GATA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA3.

    PSMA3; RARA; ESR1; SOX4; FOXC1; myc_human_gene; tff1_human_gene; GREB1; FOS; RARG; TAL1; STAT1

    McMullen, E; Samuelson, M; et al. GATA3 Is Frequently Expressed By Estrogen Receptor-Negative Breast Cancers: A Comparison of Two Commercially Available Monoclonal Antibodies. MODERN PATHOLOGY 28:56A-56A(2015).
    Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).

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