gcgr
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  • Official Full Name
  • glucagon receptor
  • Background
  • The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
  • Synonyms
  • GCGR; glucagon receptor; GGR; GL R; GL-R; GLR; GLR_HUMAN; Glucagon receptor precursor; MGC138246
Cat.#:GCGR-001HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human GCGR Protein, His-tagged
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Cat.#:GCGR-2338MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse GCGR Protein (27-143 aa), His-tagged
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Cat.#:GCGR-518MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse GCGR Protein (27-143 aa), GST-tagged
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Cat.#:GCGR-2488RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GCGR Protein
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Cat.#:GCGR-5989HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GCGR 293 Cell Lysate
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Cat.#:Kit-1029Tag:N/A
Source (Host):Species:
Product nameTotal Collagen Assay Kit (Colorimetric)
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Cat.#:Kit-1027Tag:N/A
Source (Host):Species:
Product namePhospho-ERK1/2 (Thr202/Tyr204) Translocation Assay Kit (Cell-Based)
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Cat.#:Kit-1249Tag:N/A
Source (Host):Species:
Product nameGCGR Total GPCR Internalization Assay Kit
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Cat.#:Kit-1250Tag:N/A
Source (Host):Species:
Product nameGCGR CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1251Tag:N/A
Source (Host):Species:
Product nameCHO-K1 GCGR Bioassay Kit
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Cat.#:Kit-1252Tag:N/A
Source (Host):Species:
Product namecAMP GCGR CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1253Tag:N/A
Source (Host):Species:
Product nameGCGR CHO-K1 β-Arrestin-1 GPCR Assay Kit
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Involved Pathway

GCGR involved in several pathways and played different roles in them. We selected most pathways GCGR participated on our site, such as Neuroactive ligand-receptor interaction, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
PTH1RB; GRIA3B; CHRNA1; P2RY8; P2RY10; TSHR; GRIK2; GALR3; LEPB; CHRNA4
Glucagon signaling pathway
G6PC; PHKG1; CAMK2D; ITPR1; CAMK2G; LDHA; PCK1; PRKAA2; GCG; PGAM2

Protein Function

GCGR has several biochemical functions, for example, glucagon receptor activity, guanyl-nucleotide exchange factor activity, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCGR itself. We selected most functions GCGR had, and list some proteins which have the same functions with GCGR. You can find most of the proteins on our site.
Function
Related Protein
Function glucagon receptor activity
Related Protein GCGR; GLP1R; GLP2R
Function guanyl-nucleotide exchange factor activity
Related Protein TRIOA; FGD5; DOCK8; FLCN; TBXA2R; ARHGEF11; TAGAP; RALGPS2; ITSN1; PTGIR
Function peptide hormone binding
Related Protein HCRTR2; GCGR; AGTR1A; PTH1RA; GALR3; NPR1; ANXA5; AGTR1B; RXFP2; NPR3

Interacting Protein

GCGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCGR here. Most of them are supplied by our site. Hope this information will be useful for your research of GCGR.
PSMD2; Hacd3; TGM2; TP63

GCGR Related Articles

Jun, LS; Millican, RL; et al. Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production. DIABETES 64:819-827(2015).
Wang, MY; Yan, H; et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2503-2508(2015).