GJA1

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GJA1

Official Full Name gap junction protein, alpha 1, 43kDa
Background This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq, Jul 2008]
Synonyms GJA1; gap junction protein, alpha 1, 43kDa; HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; DFNB38; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GJA1-350H Recombinant Human GJA1 Protein, His-tagged E.coli His
    Human GJA1-5923HCL Recombinant Human GJA1 293 Cell Lysate HEK293 N/A
    Mouse Gja1-351M Recombinant Mouse Gja1 Protein, His-tagged E.coli His
    Mouse GJA1-6368M Recombinant Mouse GJA1 Protein Mammalian Cell His
    Mouse GJA1-893M Recombinant Mouse GJA1 protein, His-tagged E.coli His
    Rat GJA1-2545R Recombinant Rat GJA1 Protein Mammalian Cell His
    Rat Gja1-352R Recombinant Rat Gja1 Protein, His-tagged E.coli His
    Cynomolgus Monkey GJA1-545C Recombinant Cynomolgus GJA1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque GJA1-1857R Recombinant Rhesus monkey GJA1 Protein, His-tagged Mammalian Cell His
    Chicken GJA1-6155C Recombinant Chicken GJA1 Mammalian Cell His

    GJA1 involved in several pathways and played different roles in them. We selected most pathways GJA1 participated on our site, such as Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gap junction ITPR3; PRKACBB; PRKG2; PRKCBB; TUBA1A; CX43; PDGFB; TUBB2B; GNA11B; SOS1
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA4; ITGA5; RYR2; ACTN1; SGCG; CDH2; ITGB8; ACTN4; CACNG2; SGCB

    GJA1 has several biochemical functions, for example, PDZ domain binding, SH3 domain binding, connexin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA1 itself. We selected most functions GJA1 had, and list some proteins which have the same functions with GJA1. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding LLGL2; PLEKHA2; CLCN3; SNTA1; DLG3; ARHGEF16; PSEN1; ACCN3; FZD3; SLC9A3
    SH3 domain binding NCKIPSD; KHDRBS3; AFAP1L2; OSTF1; RAD9; ARHGAP17; GRB2; ADAM15; DTX1; RAD9A
    connexin binding GJA5; CNSTB; CNST; GJA1; CXADR; CAV3
    gap junction channel activity CX30.3; GJA1; GJA8; PANX2; CX23; GJA10; GJD3; GJC1; GJB3; CX52.6
    gap junction channel activity involved in cardiac conduction electrical coupling GJA1; GJA5
    gap junction channel activity involved in cell communication by electrical coupling GJA1
    ion transmembrane transporter activity SFXN4; GJA1; SFXN3; S100A6; SFXN2; SFXN1; SFXN5A; TRPV2; SFXN5B; LASP1
    protein binding RSPO1; BNIP2; DOK1; VTN; CCNA1; SETD7; FRMD4B; GALR1; TRIM28; BRD9
    signal transducer activity SH2B3; TAS2R139; O3far1; IL10RA; ADORA2AB; VALOPA; DRD2B; BAI2; GNA12A; TAS1R2.1

    GJA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA1.

    TJP1; CSK; DSC2; TFCP2; SRC

    Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).
    Choudhury, A; Khole, VV; et al. HSP90 Antibodies: A Detrimental Factor Responsible for Ovarian Dysfunction. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 70:372-385(2013).

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