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Recombinant Human GJA1 protein, His-tagged

Cat.No. : GJA1-350H
Product Overview : Recombinant Human GJA1 protein(NP_000156.1)(Ser244~Ile382), fused to His-tag at N-terminus, was expressed in E. coli.
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Description : This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations.
Source : E. coli
Species : Human
Tag : His
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 26kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser244~Ile382
AA Sequence : SDPYHATSGALSPAKDCGSQKYAYF NGCSSPTAPLSPMSPPGYKLVTGDR NNSSCRNYNKQASEQNWANYSAEQN RMGQAGSTISNSHAQPFDFPDDNQN SKKLAAGHELQPLAIVDQRPSSRAS SRASSRPRPDDLEI
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 80%
Notes : The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles.
Store at 2-8°C for one month.
Aliquot and store at -80ºC for 12 months.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Publication :
An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins (2020)
Gene Name : GJA1 gap junction protein alpha 1 [ Homo sapiens (human) ]
Official Symbol : GJA1
Synonyms : HSS; CMDR; CX43; EKVP; GJAL; ODDD; AVSD3; EKVP3; HLHS1; PPKCA
Gene ID : 2697
mRNA Refseq : NM_000165.5
Protein Refseq : NP_000156.1
MIM : 121014
UniProt ID : P17302

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can GJA1 be a potential therapeutic target for cancer treatment? 05/25/2021

Research suggests that targeting GJA1 may have therapeutic potential in cancer treatment, although further studies are needed to validate this approach.

Are there any neurologic implications of GJA1 mutations? 09/04/2019

Yes, GJA1 mutations have been associated with neurological disorders, including Charcot-Marie-Tooth disease, a group of peripheral neuropathies affecting motor and sensory nerves.

How is GJA1 involved in bone development and maintenance? 04/01/2019

GJA1 is expressed in bone cells and plays a role in the communication between osteoblasts and osteocytes. Mutations may lead to skeletal abnormalities.

Are there any diagnostic tools specifically targeting GJA1 for clinical use? 02/09/2019

Currently, there are no widely used diagnostic tools specifically targeting GJA1. However, research is ongoing to explore its potential as a diagnostic marker.

Are there ongoing clinical trials targeting GJA1 for therapeutic interventions? 10/23/2017

Yes, there are some clinical trials exploring the modulation of GJA1 expression or function for potential therapeutic benefits in certain diseases.

Customer Reviews (3)

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02/12/2021

    They actively listen to my experimental needs and tailor their services accordingly, recognizing the unique requirements of my research.

    08/22/2018

      With their assistance, I can confidently delve into the intricacies of GJA1 and make significant contributions to the field of ARID3C-related research.

      10/02/2016

        This collaborative partnership contributes to a productive and efficient research experience, as I can rely on their expertise and assistance throughout the process.

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