gusb
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  • Official Full Name
  • glucuronidase, beta
  • Background
  • This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
  • Synonyms
  • GUSB; glucuronidase, beta; beta-glucuronidase; Ac2-223; asd; Beta G1; Beta glucuronidase; Beta-G1; BG; BGLR; BGLR_HUMAN; FLJ39445; Glucuronidase beta; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; MPS 7; MPS7; OTTHUMP00000159848; OTTHUMP00000210106; beta-D-glucuronidase
Cat.#:GUSB-001HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GUSB Protein
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Cat.#:GUSB-4500HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GUSB Protein, GST-tagged
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Cat.#:GUSB-179HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human GUSB, His-tagged
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Cat.#:GUSB-27205THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GUSB
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Cat.#:GUSB-6928HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUSB protein, His & T7-tagged
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Cat.#:Gusb-6929MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gusb protein, His & T7-tagged
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Cat.#:GUSB-7397MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GUSB Protein
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Cat.#:GUSB-2763RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GUSB Protein
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Cat.#:Gusb-6930RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gusb protein, His-tagged
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Cat.#:GUSB-3374CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GUSB
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Cat.#:GUSB-12HTag:
Source (Host):Species:Helix pomatia
Product nameNative Helix pomatia b-Glucuronidase
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Cat.#:GUSB-5673HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GUSB 293 Cell Lysate
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Involved Pathway

GUSB involved in several pathways and played different roles in them. We selected most pathways GUSB participated on our site, such as Pentose and glucuronate interconversions, Starch and sucrose metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT1A2; UGT2A3; UGT2B7; UGP2; UGT2B15; GUSB; ALDH1B1; Akr1b3; UGP2A; UGDH
Starch and sucrose metabolism
G6PC3; UGT1A3; UGP2; GBA3; AMY1B; UGT2A3; GPI1; UGT1A4; G6PC; UGT1A6
Glycosaminoglycan degradation
HYAL4; HEXA; HYAL3; GNSA; HEXB; GUSB; GNS; IDS; NAGLU; SPAM1
Porphyrin and chlorophyll metabolism
UGT1A6; COX15; GUSB; FECH; HMOX1; UGT1A9; BLVRA; COX10; UGT1AB; UGT1A6A
Drug metabolism - other enzymes
TYMP; NAT1; CES1D; NAT2; UGT1AB; DPYD; UCK2B; NAT; TPMT; PNAT3
Metabolic pathways
ADH1C; CMBL; ALOX12; GALNTL4; ADO; NOS3; MRI1; PTGES; G6PCA.2; ENO1
Lysosome
CLN3; PPT1; CTNS; CTSZ; CTSO; SUMF1; CTSJ; CTSSB.2; NAGA; AP1G2

Protein Function

GUSB has several biochemical functions, for example, beta-glucuronidase activity, protein domain specific binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GUSB itself. We selected most functions GUSB had, and list some proteins which have the same functions with GUSB. You can find most of the proteins on our site.
Function
Related Protein
Function beta-glucuronidase activity
Related Protein GUSB; HPSE
Function protein domain specific binding
Related Protein YWHAQ; RUNX2; RARA; HIST1H4H; IPCEF1; ATN1; RAB6A; CHMP1A; LIN7B; AIDA
Function receptor binding
Related Protein CD2; PCSK1N; CAT; SRI; SMARCD1; RSPO1; GSTM2; F2; WIPI1; ANGPT2

Interacting Protein

GUSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUSB here. Most of them are supplied by our site. Hope this information will be useful for your research of GUSB.
GIT2; A2M; cona_canen

GUSB Related Articles

Boado, RJ; Pardridge, WM; et al. Genetic engineering of IgG-glucuronidase fusion proteins. JOURNAL OF DRUG TARGETING 18:205-211(2010).
Zhang, Y; Wang, Y; et al. Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer. PHARMACEUTICAL RESEARCH 25:400-406(2008).