Recombinant Human GUSB

• Cat.No.: GUSB-27205TH
• Product Overview: Recombinant full length Human beta glucuronidase with N terminal proprietary tag, 95.41kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 630 amino acids
• Description: This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
• Molecular Weight: 95.410kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: GLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEE QWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWY EREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLE HEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTL PPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLY TTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVR LLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLY SLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGK PFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAF RTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNV SLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGY YLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICL NSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEY GAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYV VGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFL LRERYWKIANETRYPHSVAKSQCLENSLFT
• Sequence Similarities: Belongs to the glycosyl hydrolase 2 family.

Gene Information

• Gene Name: GUSB glucuronidase, beta [ Homo sapiens ]
• Official Symbol: GUSB
• Synonyms: GUSB; glucuronidase, beta; beta-glucuronidase
• Gene ID: 2990
• mRNA Refseq: NM_000181
• Protein Refseq: NP_000172
• MIM: 611499
• Uniprot ID: P08236
• Chromosome Location: 7q11.21
• Pathway: Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Chondroitin sulfate degradation, organism-specific biosystem
• Function: beta-glucuronidase activity; cation binding; sugar binding