| Description : |
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
74.7 kDa |
| AA Sequence : |
MARGSAVAWAALGPLLWGCALGLQG GMLYPQESPSRECKELDGLWSFRAD FSDNRRRGFEEQWYRRPLWESGPTV DMPVPSSFNDISQDWRLRHFVGWVW YEREVILPERWTQDLRTRVVLRIGS AHSYAIVWVNGVDTLEHEGGYLPFE ADISNLVQVGPLPSRLRITIAINNT LTPTTLPPGTIQYLTDTSKYPKGYF VQNTYFDFFNYAGLQRSVLLYTTPT TYIDDITVTTSVEQDSGLVNYQISV KGSNLFKLEVRLLDAENKVVANGTG TQGQLKVPGVSLWWPYLMHERPAYL YSLEVQLTAQTSLGPVSDFYTLPVG IRTVAVTKSQFLINGKPFYFHGVNK HEDADIRGKGFDWPLLVKDFNLLRW LGANAFRTSHYPYAEEVMQMCDRYG IVVIDECPGVGLALPQFFNNVSLHH HMQVMEEVVRRDKNHPAVVMWSVAN EPASHLESAGYYLKMVIAHTKSLDP SRPVTFVSNSNYAADKGAPYVDVIC LNSYYSWYHDYGHLELIQLQLATQF ENWYKKYQKPIIQSEYGAETIAGFH QDPPLMFTEEYQKSLLEQYHLGLDQ KRRKYVVGELIWNFADFMTEQSPTR VLGNKKGIFTRQRQPKSAAFLLRER YWKIANETRYPHSVAKSQCLENSLF TTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
