hdac2
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  • Official Full Name
  • histone deacetylase 2
  • Background
  • This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
  • Synonyms
  • HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;
Cat.#:HDAC2-3565HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HDAC2, His-tagged
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Cat.#:HDAC2-4642HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human HDAC2 Protein, His-tagged
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Cat.#:HDAC2-1590HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 2, GST-tagged
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Cat.#:HDAC2-1699HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 2, His-tagged
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Cat.#:HDAC2-13706HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC2, GST-tagged
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Cat.#:HDAC2-28263THTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC2, His-tagged
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Cat.#:HDAC2-28264THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC2
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Cat.#:HDAC2-393HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HDAC2 protein, His-tagged
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Cat.#:HDAC2-93HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC2 Protein, GST-tagged
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Cat.#:HDAC2-7529MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC2 Protein
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Cat.#:HDAC2-6394CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC2
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Cat.#:HDAC2-1355HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC2 (Active), GST-tagged
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Cat.#:HDAC2-5605HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC2 293 Cell Lysate
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Cat.#:Kit-1738Tag:
Source (Host):Species:
Product nameHDAC2 Kinetic Assay Kit
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Cat.#:Kit-2284Tag:
Source (Host):Species:
Product nameHDAC2 Immunoprecipitation (IP) & Activity Assay Kit
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Involved Pathway

HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
VRK2; ABL1; EP300; CDK11B; CEP70; SMAD4; FGFR1OP; NCAPH2; STAG2A; CENPI
Notch signaling pathway
CTBP2A; CTBP2; HES1; DLL1; DTX4; PSENEN; EP300; APH1B; CIR1; PSEN2
Thyroid hormone signaling pathway
GATA4; TRP53; PLCD4; MED17; WNT4; PRKCG; ATP2A2; CCND1; MAP2K2; HRAS
Huntingtons disease
DNAH11; ATP5G3; PLCB2; SIN3A; POLR2J; POLR2C; NDUFS2; NDUFA9; DCTN1; NDUFV1
Alcoholism
HIST1H2BM; HIST2H2BB; HDAC8; HIST1H2AP; HIST1H4K; GNB2; CALM1; PRKACA; HIST1H2AA; HIST1H4D
Epstein-Barr virus infection
PIK3R2; HSPA8; HLA-C; PIK3CD; POLR2A; CCNA2; POLR2J2; EIF2AK3; POLR2D; PIK3R1
Pathways in cancer
WNT10B; ARHGEF1; FGF8; EGLN3; PTCH2; LAMC2; PTCH1; Fgf15; ITGA3; WNT2B
Transcriptional misregulation in cancer
REL; FCGR1; MEF2C; IGF1; MLF1; TFE3; TRAF1; SLC45A3; LYL1; RARA
Viral carcinogenesis
HIST1H2BD; ACTN3; HIST1H4A; PXN; ACTN4; TRAF3; RELA; CCND1; IRF3; CCND3
Chronic myeloid leukemia
KRAS; SMAD3; TGFB3; BAD; HDAC1; PIK3R1; HDAC2; MECOM; SHC3; HRAS

Protein Function

HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC2; HDAC10; HDAC8; HDAC1; HDAC6; HDAC11; HDAC7A; HDAC5; HDAC4; HDAC3
Function NF-kappaB binding
Related Protein HDAC2; RNF25; CPNE1; CDK5RAP3; HSPA6; BCL10; TAF4B; DNAJA3; ANXA4; HIF1AN
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SMARCE1; HDAC1; CHD4; ACTL6A; SMARCC2; SMARCC1; MTA2; HDAC2; ACTB; SMARCB1
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein HDAC1; HDAC2; CHD4; MTA2; SMARCA4; ACTL6A; MBD3; RBBP4; SMARCB1; SMARCC1
Function RNA polymerase II repressing transcription factor binding
Related Protein BBS4; TBP; SIN3A; STAT3; TCF7L2; TCERG1; DMAP1; GATA6; TTC8; MTA1
Function chromatin binding
Related Protein FABP1; ZEB1; JMJD5; NR5A1A; BAP1; GATA2; PBX2; FOXO1; YBX2; NFIA
Function core promoter binding
Related Protein NEUROG3; GATA1; HDAC5; PYDC3; RB1; FOXP3; MTA1; E2F7; IFI203; HMGA2
Function deacetylase activity
Related Protein SIRT1; NDST3; MAPK1IP1L; MACROD1; NDST4; C6orf130; HDAC2; HDAC1; MACROD2; AADAC
Function enzyme binding
Related Protein NFKBIA; PPP1R3D; MAP2K7; BIRC5; MDM2; CBX4; Slc4a2; KIAA1967; HIST1H2AN; TSPAN15
Function heat shock protein binding
Related Protein TFAM; DLST; TOMM34; CDC37; HSPA1B; GM5506; SSUH2RS1; HDAC2; CDC37L1; PARK2
Function histone deacetylase activity
Related Protein HDAC1; HDAC6; SIRT1; HDAC8; HDAC10; MTA2; HDAC2; HDAC5; HDAC4; HDAC9B
Function contributes_to nucleosomal DNA binding
Related Protein MBD3; SMARCA4; RBBP4; SMARCC1; SMARCE1; ACTB; GATAD2B; SMARCB1; CHD4; HDAC2
Function poly(A) RNA binding
Related Protein PRDX1; ILF3; ABCF1; PPIL4; ERI3; CDC5L; PRPF4B; NOL6; DBR1; AHNAK
Function protein binding
Related Protein RAB1; RNF11; SART3; MMS22L; ASIC1; TMEM59; SLC25A23; C16orf79; MPG; ISOC1
Function protein deacetylase activity
Related Protein SIN3A; HDAC5; HDAC1; HDAC4; HDAC10; SIRT1; HDAC3; SIRT2; HDAC2; HDAC9
Function sequence-specific DNA binding
Related Protein OSR2; POU5F1; TFAP2A; OTX1B; FOXQ1; BCL2; LHX2; PRRXL1; EN2; NKX6.1
Function transcription factor binding
Related Protein IRF4; ATOH8; ADD1; SOX8; BPTF; HMGB2; ESR1; PER1; TRIB2; PPID

Interacting Protein

HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.
HDAC1; SIN3A; MTA1

HDAC2 Related Articles

Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).