hdac2
Share
  • Official Full Name
  • histone deacetylase 2
  • Background
  • This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
  • Synonyms
  • HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;
Cat.#:HDAC2-3565HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human HDAC2, His-tagged
+Inquiry
Cat.#:HDAC2-4642HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human HDAC2 Protein, His-tagged
+Inquiry
Cat.#:HDAC2-1590HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 2, GST-tagged
+Inquiry
Cat.#:HDAC2-1699HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 2, His-tagged
+Inquiry
Cat.#:HDAC2-13706HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC2, GST-tagged
+Inquiry
Cat.#:HDAC2-28263THTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC2, His-tagged
+Inquiry
Cat.#:HDAC2-28264THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC2
+Inquiry
Cat.#:HDAC2-393HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HDAC2 protein, His-tagged
+Inquiry
Cat.#:HDAC2-93HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC2 Protein, GST-tagged
+Inquiry
Cat.#:HDAC2-7529MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC2 Protein
+Inquiry
Cat.#:HDAC2-6394CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC2
+Inquiry
Cat.#:HDAC2-1355HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC2 (Active), GST-tagged
+Inquiry
Cat.#:HDAC2-5605HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC2 293 Cell Lysate
+Inquiry
Cat.#:Kit-1738Tag:
Source (Host):Species:
Product nameHDAC2 Kinetic Assay Kit
+Inquiry
Cat.#:Kit-2284Tag:
Source (Host):Species:
Product nameHDAC2 Immunoprecipitation (IP) & Activity Assay Kit
+Inquiry

Involved Pathway

HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
SMC1AL; NCAPD3; RBBP4; SYCP2; GADD45B; TCTN2; MND1; RAD17; YWHAG; SUN1
Notch signaling pathway
TUBB3; DNER; LNX1; CTBP1; NUMB; SNW1; DVL3A; MFNG; DLL1; DLA
Thyroid hormone signaling pathway
MAPK1; HDAC2; MED13L; MAP2K1; BAD; ITGB3; PLCG1; RCAN1; SLC2A1; GATA4
Huntingtons disease
PLCB3; Atp5g2; NDUFV2; NDUFB7; HAP1; COX8A; NDUFB4; IFT57; HDAC2; DCTN4
Alcoholism
DDC; GNG7; RAF1; HIST1H2BM; H2AFB1; H2AFV; CAMK4; CALML5; HIST1H2BJ; PPP1CC
Epstein-Barr virus infection
TBPL1; CD38; HSPA1B; PTMA; ICAM1; HLA-DQA2; POLR3B; POLR2D; HLA-DQB1; HLA-DRB1
Pathways in cancer
PIK3R2; KIT; WNT3; PGF; Kitl; RAC2; WNT7B; ITGA2B; FZD2; GNA11
Transcriptional misregulation in cancer
HDAC2; BMP2K; MEIS1; PPARG; Bcl2a1b; IL2RB; HOXA11; HIST1H3I; DDX5; FCGR1
Viral carcinogenesis
PXN; KAT2B; CDC42; TBP; ATP6V0D2; HIST1H2BE; GTF2H4; RBL2; YWHAG; HIST1H2BA
Chronic myeloid leukemia
CBLC; ABL1; SHC2; CCND1; AKT2; RELA; AKT1; MAP2K1; RB1; SOS1

Protein Function

HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7A; HDAC3; HDAC11; HDAC5; HDAC9B; HDAC7; HDAC8; HDAC6; HDAC4; HDAC2
Function NF-kappaB binding
Related Protein HDAC3; AP1S2; CDKN2A; PSMA6; NFKBIA; NFKBID; HSPA6; FAF1; ANKRD42; CPNE1
Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HDAC2; SMARCA4; ACTB; SMARCB1; SMARCC2; RBBP4; MTA2; SMARCE1; CHD4; GATAD2B
Function contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein SMARCC2; GATAD2B; SMARCC1; ACTL6A; ACTB; RBBP4; MTA2; HDAC2; SMARCA4; CHD4
Function RNA polymerase II repressing transcription factor binding
Related Protein SIN3A; DMAP1; PPARA; BBS10; CHD4; BBS5; SP1; PROL1; STAT3; GTF2A2
Function chromatin binding
Related Protein BAZ1B; TRPS1; CBX7; JMJD5; CRX; SUZ12; SIX1; AIRE; ELK1; EOMES
Function core promoter binding
Related Protein CLOCK; PSPC1; IRF9; TFAP2C; SAFB; AGO2; KDM3A; MYOG; RBMX; INSM1B
Function deacetylase activity
Related Protein AADAC; NDST4; SIRT1; MACROD1; NDST3; MAPK1IP1L; NDST1; HDAC1; MACROD2; HDAC2
Function enzyme binding
Related Protein ATP2A2; TAF10; SORT1; IQCB1; PRKDC; SLC18A1; TMBIM6; SCNM1-PS; THRB; PEX5
Function heat shock protein binding
Related Protein HSPA8; PACRG; DNAJA2; KCNJ11; DNAJC7; DNAJB6; CDC37L1; DNAJA3A; GPR37; PARK2
Function histone deacetylase activity
Related Protein SIRT1; HDAC1; ATXN3L; NACC2; HDAC2; MTA2; SIRT2; HDAC10; HDAC4; HDAC3
Function contributes_to nucleosomal DNA binding
Related Protein HDAC1; GATAD2B; HDAC2; ACTB; ACTL6A; SMARCA4; RBBP4; SMARCB1; SMARCC1; SMARCE1
Function poly(A) RNA binding
Related Protein ZFP326; PRAC; HSP90AA1; LUC7L3; PURB; TRA2A; SLC16A3; TMEM38A; CSDE1; COA6
Function protein binding
Related Protein EPB49; DDX19B; NUP62L; PYY; DDX21; MTMR2; CHORDC1; H3F3B; NDUFS7; CTBP1
Function protein deacetylase activity
Related Protein SIRT2; HDAC9; SIN3A; HDAC5; SIRT1; HDAC4; HDAC3; HDAC2; HDAC10; HDAC1
Function sequence-specific DNA binding
Related Protein DLX6; DLX1A; HOXC8; HOXA7; FLI1A; ARX; NFE2; FOXC1A; MNX2A; DMRT2
Function transcription factor binding
Related Protein SMAD2; MYOD1; MYC; PRKDC; DR1; DOT1L; ADD1; TRERF1; PPARG; ARRB1

Interacting Protein

HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.
HDAC1; SIN3A; MTA1

HDAC2 Related Articles

Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).