HDAC2

  • Official Full Name

    histone deacetylase 2
  • Overview

    This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
  • Synonyms

    HDAC2;histone deacetylase 2;HD2;RPD3;YAF1;YY1-associated factor 1;transcriptional regulator homolog RPD3

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Rat
  • E.coli
  • Insect Cells
  • Sf9 Cells
  • Human
  • Hi-5 Insect Cells
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Fc
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
HDAC2-13706H Recombinant Human HDAC2, GST-tagged E.coli Human GST C-term-299a.a.
HDAC2-393H Active Recombinant Human HDAC2 protein, His-tagged Insect Cells Human His
HDAC2-1355H Active Recombinant Human HDAC2, GST-tagged Sf9 Cells Human GST Full length
HDAC2-28263TH Active Recombinant Human HDAC2, His-tagged Insect Cells Human His
HDAC2-1590H Recombinant Human Histone Deacetylase 2, GST-tagged Sf9 Cells Human GST
HDAC2-1699H Recombinant Human Histone Deacetylase 2, His-tagged Human Human His
HDAC2-28264TH Recombinant Human HDAC2 Insect Cells Human Non 488 amino acids
HDAC2-3565H Recombinant Human HDAC2, His-tagged Hi-5 Insect Cells Human His
HDAC2-4642H Recombinant Human HDAC2 Protein, His-tagged Insect Cells Human His
HDAC2-6394C Recombinant Chicken HDAC2 Mammalian Cells Chicken His
HDAC2-7529M Recombinant Mouse HDAC2 Protein Mammalian Cells Mouse His
HDAC2-93H Recombinant Human HDAC2 Protein, GST-tagged Insect Cells Human GST 1-488
HDAC2-5605HCL Recombinant Human HDAC2 293 Cell Lysate HEK293 Human Non
HDAC1-551H Recombinant Human HDAC1 protein, His-tagged E.coli Human His Met1~Ile428
HDAC212813H Recombinant Human HDAC2 (1-488)-HIS (digested with Trypsin) Protein Human
HDAC2-13707H Recombinant Human HDAC2 protein, His/GST-tagged E.coli Human GST&His Met1~Pro488
HDAC2-13708H Recombinant Human HDAC2 protein, His-tagged E.coli Human His Met1~Pro488
Hdac2-1621M Recombinant Mouse Hdac2 Protein, His&GST-tagged E.coli Mouse GST&His Met1-Pro488
HDAC2-21R Recombinant Rat HDAC2 protein(Met1~Pro488), His-tagged E.coli Rat His Met1~Pro488
HDAC2-2984H Recombinant Human HDAC2 Protein (Full Length), C-Fc tagged Mammalian Cells Human Fc Full L. Full Length
HDAC2-2985H Recombinant Human HDAC2 Protein (Pro386-Pro488), N-His tagged E.coli Human His Pro386-Pro488
HDAC2-4090M Recombinant Mouse HDAC2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HDAC2-4090M-B Recombinant Mouse HDAC2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
HDAC2-47H Recombinant Human HDAC2 Protein, His-tagged Insect Cells Human His
Kit-1738 HDAC2 Kinetic Assay Kit Non
Kit-2284 HDAC2 Immunoprecipitation (IP) & Activity Assay Kit Non

    Involved Pathway

    HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection PSMD8,CD40,IL10RA,MAPK12,PRKACG,POLR2C,XPO1,HSPA6,HLA-DRB4,MAP2K4
    Chronic myeloid leukemia TGFB3,PIK3CG,RB1,BAD,PIK3R2,HDAC1,PIK3CB,RAF1,SHC2,CBLC
    Viral carcinogenesis NFKBIA,HIST1H2BM,SRF,HIST1H4K,MAPK3,CREB3L2,EGR3,HIST1H2BF,GTF2A1L,HIST1H4A
    Pathways in cancer AGTR1A,MAP2K1,BDKRB2,SMO,WNT9B,CSF1R,BIRC8,Flt3l,NKX3-1,PTGER3
    Huntingtons disease NDUFA6,CREB3L1,ATP5F1,NDUFA4,SOD1,DNALC4,DNAL1,NDUFA8,SLC25A4,CREB3L2
    Cell cycle MAU2,CUL1,YWHAG1,MYC,NDEL1A,TUBGCP3,CEP78,ORC4L,MSH4,HIST2H3C
    Alcoholism HIST1H4M,HIST2H2AC,H2AFB3,HIST2H2BE,HIST1H2AH,HIST1H2BE,MAPK1,NTRK2,HIST1H2BC,HIST3H2BB-PS
    Transcriptional misregulation in cancer MLL1,ASPSCR1,TRAF1,LRP2BP,HPGD,RUNX1,KDM6A,RXRG,MDM2,MLLT3
    Thyroid hormone signaling pathway PLN,RXRG,MED12L,MED30,PIK3R1,SLC16A2,DIO1,PRKACG,RXRB,MAPK1

    Protein Function

    HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),NF-kappaB binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC3,HDAC4,HDAC8,HDAC10,HDAC6,HDAC9,HDAC9B,HDAC11,HDAC5,HDAC7A
    histone deacetylase activity NACC2,HDAC6,HDAC4,HDAC8,HDAC9B,HDAC1,MTA2,HDAC5,HDAC11,SIRT1
    RNA polymerase II repressing transcription factor binding GATA6,BBS10,BBS7,PPARA,TTC8,SP1,MIXL1,STAT3,MTA2,GSC
    protein deacetylase activity SIN3A,HDAC10,HDAC3,SIRT2,HDAC5,HDAC4,HDAC1,SIRT1,HDAC9
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding ACTL6A,SMARCE1,SMARCC2,CHD4,MTA2,ACTB,MBD3,HDAC1,SMARCB1,SMARCA4
    deacetylase activity MACROD2,NDST3,AADAC,SIRT1,NDST1,MAPK1IP1L,MACROD1,NDST4,HDAC1,C6orf130
    core promoter binding HMGA2,NEUROG3,E2F3,HDAC1,PSPC1,IRF9,SFPQ,CRY1,ELK4,RBMX
    transcription factor binding MAPK1,TRIB1,IFI16,TAF7,VDRA,HMGA1,FOXF2,HES2,LEF1,NAB2
    chromatin binding SFPQ,TAF2,EYA3,TICRR,JMJD5,MEF2C,UXT,YBX1,PLAC8,NKX2

    Interacting Protein

    HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.

    HDAC1;SIN3A;MTA1

    HDAC2 Related Signal Pathway

    Resources

    References

    • Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
    • Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).

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