HDAC4

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HDAC4

Official Full Name histone deacetylase 4
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Synonyms HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase A;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC4-022H Recombinant Human HDAC4 Protein, GST-tagged Insect Cells GST
    Mouse Hdac4-3369M Recombinant Mouse Hdac4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HDAC4-001HCL Recombinant Human HDAC4 cell lysate Insect Cell N/A
    Human HDAC4-1053H Recombinant Human HDAC4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HDAC4-1357H Recombinant Human HDAC4 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC4-1592H Recombinant Human Distone Deacetylase 4, GST-tagged Sf9 Insect Cell GST
    Human HDAC4-28265TH Recombinant Human HDAC4 Sf9 Insect Cell N/A
    Human HDAC4-28266TH Recombinant Human HDAC4, His-tagged E.coli His
    Human HDAC4-395H Recombinant Human Histone Deacetylase 4, GST-tagged Insect Cell GST
    Human HDAC4-4645H Recombinant Human HDAC4 Protein, GST-tagged Wheat Germ GST
    Human HDAC4-518H Recombinant Human HDAC4, Gly & Pro tagged Insect Cell His
    Human HDAC4-95H Recombinant Human HDAC4 Protein, GST/His-tagged Insect Cell GST/His
    Mouse Hdac4-1369M Recombinant Mouse Hdac4 protein, His-tagged E.coli His
    Mouse HDAC4-7531M Recombinant Mouse HDAC4 Protein Mammalian Cell His
    Rat HDAC4-2817R Recombinant Rat HDAC4 Protein Mammalian Cell His
    Chicken HDAC4-5886C Recombinant Chicken HDAC4 Mammalian Cell His
    Zebrafish HDAC4-3616Z Recombinant Zebrafish HDAC4 Mammalian Cell His
    Kit-1740 HDAC4 Fluorogenic Assay Kit N/A

    HDAC4 involved in several pathways and played different roles in them. We selected most pathways HDAC4 participated on our site, such as Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism HDAC7A; HIST1H2AK; CALML3; GM14476; H2AFJ; HIST1H2BP; HIST1H3F; HIST1H2AJ; HIST2H2BB; HIST2H4
    Epstein-Barr virus infection ICAM1; FCER2; POLR2J2; POLR2C; TYK2; HLA-DQA1; POLR3B; CR2; POLR2J; PSMD4
    Viral carcinogenesis HDAC7A; SYK; CREB5; KAT2B; HIST1H2BB; NFKBIA; IKBKG; RHOA; PIK3R1; CDK1
    MicroRNAs in cancer PDGFRA; IRS2; CCND2; PRKCG; NRAS; HRAS; BRCA1; IGF2BP1; ZEB2; CCNE2

    HDAC4 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC4 itself. We selected most functions HDAC4 had, and list some proteins which have the same functions with HDAC4. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC8; HDAC11; HDAC1; HDAC4; HDAC3; HDAC7; HDAC9B; HDAC9; HDAC10; HDAC6
    RNA polymerase III transcription factor binding HDAC4; HDAC5
    activating transcription factor binding EEF1D; ZFP516; PSIP1; PRDM16; HDAC1; TAF9; PPARG; MEF2A; HDAC7A; SMAD2
    chromatin binding NUPR1; SUV39H1; TLE4; MSH6; TWIST2; MEIS3; LRWD1; KDM6B; SP100; TBL1Y
    core promoter binding AGO1; HMGA2; E2F8; FOXP3; E2F1; PSPC1; NPAS2; FOXO3; EZH2; REST
    histone deacetylase activity HDAC9; ATXN3L; HDAC2; HDAC1; HDAC5; HDAC10; HDAC11; HDAC8; HDAC4; NACC2
    histone deacetylase binding NACC2; MEF2A; NR2E1; HOXA10; DHX36; ANKRD1; WDTC1; BCOR; BRMS1LA; USF1
    potassium ion binding KCNA4; SLC24A5; SLC24A4; SLC24A2; PDXK; PKLR; SLC24A4A; KCNJ11; ATP1A1; SLC24A1
    protein binding AP3M1; MPHOSPH6; COPS7A; ZNF785; BCOR; MKRN2; GJA1; NRIP1; RPS6KA5; IL17F
    protein deacetylase activity HDAC9; SIRT1; HDAC10; SIRT2; SIN3A; HDAC1; HDAC4; HDAC3; HDAC2; HDAC5
    protein kinase binding FAM83E; PARK2; C10orf46; BAD; BCAR1; CCNL1B; SPRY2; RAB8A; PPP1R12C; FGFR1OP
    repressing transcription factor binding HDAC7; EIF4E; PRDM5; RUNX2; MAGEA2B; CTNNB1; KAT5; TLE4; CBX5; RELA
    contributes_to sequence-specific DNA binding FIGLA; PPARG; SMAD4; TCF3; EPAS1; TRIM28; ARNT; HIF1A; HDAC4; NEUROD1
    transcription corepressor activity E4F1; MXD4; NRIP1; SFMBT1; NSD1; MECP2; LHX1A; HIPK2; RUNX1T1; TRIB3
    transcription factor binding PPARG; PPARGC1A; IGHMBP2; TWIST1; DDX3X; HDAC1; NIF3L1; PURA; HEY2; NKX2-1
    contributes_to transcription regulatory region DNA binding TCF3; NFYA; TCF12; HDAC4; NR1H3; RXRA; HAND1; NFYB; HDAC5; ATF4
    zinc ion binding MT1E; VPS8; SIVA1; MEX3B; RNF133; PHF8; BTR16; NUP153; LNPEP; NR1H3

    HDAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC4.

    YWHAG; YWHAZ; YWHAE; YWHAH

    Wild, EJ; Tabrizi, SJ; et al. Targets for Future Clinical Trials in Huntington's Disease: What's in the Pipeline?. MOVEMENT DISORDERS 29:1434-1445(2014).
    Hannan, JL; Kutlu, O; et al. Valproic Acid Prevents Penile Fibrosis and Erectile Dysfunction in Cavernous Nerve-Injured Rats. JOURNAL OF SEXUAL MEDICINE 11:1442-1451(2014).

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