hdac4
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  • Official Full Name
  • histone deacetylase 4
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase A;
Cat.#:HDAC4-1053HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HDAC4 Protein, MYC/DDK-tagged
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Cat.#:HDAC4-4645HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC4 Protein, GST-tagged
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Cat.#:HDAC4-1592HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Distone Deacetylase 4, GST-tagged
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Cat.#:HDAC4-28265THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC4
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Cat.#:HDAC4-28266THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDAC4, His-tagged
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Cat.#:HDAC4-395HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 4, GST-tagged
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Cat.#:HDAC4-518HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC4, Gly & Pro tagged
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Cat.#:HDAC4-95HTag:GST/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human HDAC4 Protein, GST/His-tagged
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Cat.#:Hdac4-1369MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdac4 protein, His-tagged
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Cat.#:HDAC4-7531MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDAC4 Protein
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Cat.#:HDAC4-2817RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDAC4 Protein
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Cat.#:HDAC4-5886CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDAC4
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Cat.#:HDAC4-3616ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDAC4
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Cat.#:HDAC4-1357HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HDAC4 (Active), GST-tagged
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Cat.#:HDAC4-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HDAC4 cell lysate
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Cat.#:Kit-1740Tag:
Source (Host):Species:
Product nameHDAC4 Fluorogenic Assay Kit
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Involved Pathway

HDAC4 involved in several pathways and played different roles in them. We selected most pathways HDAC4 participated on our site, such as Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H2AO; HIST1H2AB; PPP1CB; HIST1H4J; SLC18A1; TH; HIST1H2BL; SHC1; PDYN; HIST1H2AA
Epstein-Barr virus infection
CSNK2B; HLA-DRB3; TRADD; POLR2J; ITGAL; ENTPD1; POLR2J2; EIF2AK1; TRP53; PSMD12
Viral carcinogenesis
SRC; RBL2; NFKB1; MDM2; RB1; IKBKG; HRAS; CCNE2; STAT5A; HIST2H4A
MicroRNAs in cancer
CCND1; IRS1; BMF; HRAS; SPRY2; ABCB1; FSCN1; EFNA3; HDAC4; TP63

Protein Function

HDAC4 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC4 itself. We selected most functions HDAC4 had, and list some proteins which have the same functions with HDAC4. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7A; HDAC2; HDAC11; HDAC3; HDAC9B; HDAC9; HDAC8; HDAC4; HDAC1; HDAC7
Function RNA polymerase III transcription factor binding
Related Protein HDAC5; HDAC4
Function activating transcription factor binding
Related Protein PSIP1; MEF2C; EP300; MEF2A; TAF9; EEF1D; ATOH8; PRDM16; HDAC7; GATA4
Function chromatin binding
Related Protein NKX6-1; ELK1; CRTC2; MITF; UPF1; TICRR; NR5A1B; STAT5B; TFAM; CAPNS2
Function core promoter binding
Related Protein EZH2; CALCOCO1; SFPQ; ELK1; MTA1; SAFB; RBMX; E2F2; INSM1B; HMGA2
Function histone deacetylase activity
Related Protein MTA2; ATXN3L; HDAC11; HDAC8; HDAC4; HDAC1; HDAC2; HDAC9B; HDAC3; HDAC10
Function histone deacetylase binding
Related Protein HDAC5; SUDS3; RUNX2; CBX5; NKX2-5; HOXA10; PHB; NCOR1; TOP2B; YY1
Function potassium ion binding
Related Protein SLC24A5; PKM2; PKLR; SLC24A4A; ATP1A1; SLC24A2; PDXK; KCNJ11; SLC24A1; KCNA4
Function protein binding
Related Protein RPS6KA3; ADAM8; BLOC1S1; TMEM19; GTF2F2; MARK4; C22orf28; TUBA1A; NUBP2; LBP
Function protein deacetylase activity
Related Protein HDAC3; SIRT1; HDAC5; HDAC4; SIN3A; HDAC10; HDAC9; SIRT2; HDAC1; HDAC2
Function protein kinase binding
Related Protein TELO2; CDK5; SPAG16; SPDYB; SLC12A4; PAK2; MLKL; SPRED1; KIF14; PIH1D1
Function repressing transcription factor binding
Related Protein SKI; KAT5; HDAC7A; RELA; NOC2L; TBP; CTBP1; NFYB; GMNN; HHEX
Function contributes_to sequence-specific DNA binding
Related Protein HIF1A; TCF3; HNRNPAB; EPAS1; SMAD4; FIGLA; TRIM28; NEUROD1; ARNT; HDAC4
Function transcription corepressor activity
Related Protein CTCF; BCL11A; ALX1; TFCP2L1; SKIL; SIRT6; JAZF1; FEV; SF1; TLE2
Function transcription factor binding
Related Protein DRG1; WWP2; NKX2-5; NR0B1; MSX2; PELP1; KCNA3; HYAL1; DOT1L; RBFOX2
Function contributes_to transcription regulatory region DNA binding
Related Protein TCF12; TCF3; HAND1; TAF1; HDAC5; NR1H3; ATF4; NFYB; NFYA; RXRA
Function zinc ion binding
Related Protein ZNF385C; MICALL2A; BPTF; LMO4B; ABLIM2; PGGT1B; ZNF3; TRIM35-31; ADAMTS3; ZDHHC21

Interacting Protein

HDAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC4.
YWHAG; YWHAZ; YWHAE; YWHAH

HDAC4 Related Articles

Wild, EJ; Tabrizi, SJ; et al. Targets for Future Clinical Trials in Huntington's Disease: What's in the Pipeline?. MOVEMENT DISORDERS 29:1434-1445(2014).
Hannan, JL; Kutlu, O; et al. Valproic Acid Prevents Penile Fibrosis and Erectile Dysfunction in Cavernous Nerve-Injured Rats. JOURNAL OF SEXUAL MEDICINE 11:1442-1451(2014).