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HDAC4

  • Official Full Name

    histone deacetylase 4

  • Overview

    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
  • Synonyms

    HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDAC4-395H Active Recombinant Human Histone Deacetylase 4, GST-tagged Insect Cell GST
Human HDAC4-1357H Active Recombinant Human HDAC4, GST-tagged Sf9 Insect Cell GST 612 aa-end
Human HDAC4-95H Recombinant Human HDAC4 Protein, GST/His-tagged Insect Cell GST/His 627-1084
Human HDAC4-518H Recombinant Human HDAC4, Gly & Pro tagged Insect Cell His
Human HDAC4-1592H Recombinant Human Distone Deacetylase 4, GST-tagged Sf9 Insect Cell GST
Human HDAC4-28266TH Recombinant Human HDAC4, His-tagged E.coli His
Human HDAC4-28265TH Recombinant Human HDAC4 Sf9 Insect Cell N/A 473 amino acids
Human HDAC4-4645H Recombinant Human HDAC4 Protein, GST-tagged Wheat Germ GST
Human HDAC4-001HCL Recombinant Human HDAC4 cell lysate Insect Cell N/A
Human HDAC4-022H Recombinant Human HDAC4 Protein, GST-tagged Insect Cells GST 627-1085
Human HDAC4-095H Recombinant Human HDAC4 Protein, GST-tagged Insect cell GST 627-1085
Human HDAC4-1053H Recombinant Human HDAC4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HDAC4-256HFL Active Recombinant Full Length Human HDAC4 Protein, C-Flag-tagged Mammalian cells Flag
Human HDAC4-1044H Recombinant Human HDAC4 Protein (T648-T1057), Tag Free E.coli No tag T648-T1057
Human HDAC429133H Recombinant Human HDAC4 (648-1057) Protein
Human HDAC4-3613HF Recombinant Full Length Human HDAC4 Protein, GST-tagged In Vitro Cell Free System GST 972 amino acids
Human HDAC4-1054H Recombinant Human HDAC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HDAC423292H Recombinant Human HDAC4 (648-1057) Protein
Human HDAC4-1054H-B Recombinant Human HDAC4 Protein Pre-coupled Magnetic Beads HEK293
Human HDAC4-1308H Recombinant Human HDAC4 protein(Met612-Leu1084) Insect Cells N/A Met612-Leu1084
Human HDAC4-1045H Recombinant Human HDAC4 Protein (T648-T1057), His tagged E.coli His T648-T1057
Human HDAC4-3406H Recombinant Human HDAC4 Protein (Thr648-Thr1057), His tagged E.coli His Thr648-Thr1057
Mouse Hdac4-1369M Recombinant Mouse Hdac4 protein, His-tagged E.coli His Arg904~Leu1076
Mouse HDAC4-7531M Recombinant Mouse HDAC4 Protein Mammalian Cell His
Mouse Hdac4-3369M Recombinant Mouse Hdac4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HDAC4-4091M-B Recombinant Mouse HDAC4 Protein Pre-coupled Magnetic Beads HEK293
Mouse HDAC4-4091M Recombinant Mouse HDAC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HDAC4-2817R Recombinant Rat HDAC4 Protein Mammalian Cell His
Rat HDAC4-2472R-B Recombinant Rat HDAC4 Protein Pre-coupled Magnetic Beads HEK293
Rat HDAC4-2472R Recombinant Rat HDAC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HDAC4-3616Z Recombinant Zebrafish HDAC4 Mammalian Cell His
Chicken HDAC4-5886C Recombinant Chicken HDAC4 Mammalian Cell His
Kit-1740 HDAC4 Fluorogenic Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDAC4 Related Articles
  • HDAC4 Related Research Area
  • HDAC4 Related Signal Pathway

HDAC4 involved in several pathways and played different roles in them. We selected most pathways HDAC4 participated on our site, such as Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismGNGT2;HIST1H2AL;CREB5;GRIN3B;HIST1H2BK;GNG2;HIST1H4G;HIST1H2AK;HIST1H2AD
Epstein-Barr virus infectionAKAP8L;PSMD6;HSPB1;EIF2AK2;POLR2J;YWHAH;SPN;POLR2J2;SNW1
Viral carcinogenesisSKP2;HLA-C;HNRNPK;EGR3;HIST1H4H;TRAF2;HIST1H2BC;CASP8;ACTN3
MicroRNAs in cancerSTAT3;MTOR;KRAS;SLC7A1;SPRY2;MDM2;NRAS;APC2;MARCKS

HDAC4 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC4 itself. We selected most functions HDAC4 had, and list some proteins which have the same functions with HDAC4. You can find most of the proteins on our site.

Function Related Protein
NAD-dependent histone deacetylase activity (H3-K14 specific)HDAC9B;HDAC1;HDAC8;HDAC4;HDAC2;HDAC7;HDAC6;HDAC5;HDAC3
RNA polymerase III transcription factor bindingHDAC5;HDAC4
activating transcription factor bindingPPARG;ZFP516;HDAC7A;EEF1D;HDAC1;MEF2C;TAF9;PSIP1;MEF2D
chromatin bindingSNAI2;SMAD6;ZMYND11;PYGO2;ARID3A;ASF1A;JMJD5;TOP1;CENPB
core promoter bindingRBMX;ARNTL;IFI16;E2F3;MTF1;NONO;PYDC3;HDAC2;HNRNPU
histone deacetylase activityHDAC1;HDAC4;HDAC8;HDAC9;HDAC2;SIRT2;HDAC7;HDAC6;SIRT1
histone deacetylase bindingGCM1;FOXP3;MYOCD;TRAF6;SKOR2;MEF2A;CDC20;MAPK8;NCOR2
potassium ion bindingKCNJ11;ATP1A1;PKM2;PKLR;SLC24A1;HDAC4;PKMB;SLC24A2;PKMA
protein bindingHELLS;MICU1;SMAD5;THSD4;C19orf73;NELL2;MAPK11;BPTF;CTSG
protein deacetylase activitySIRT1;HDAC4;HDAC2;SIN3A;HDAC10;SIRT2;HDAC5;HDAC3;HDAC1
protein kinase bindingSPDYB;NSF;HCLS1;RB1CC1;TPCN2;PTK2;IBTK;PRKCZ;CD3E
repressing transcription factor bindingMYC;CBX5;KAT5;HDAC5;TBP;ARNTL;HDAC1;HDAC4;NOC2L
contributes_to sequence-specific DNA bindingPPARG;HIF1A;ARNT;SMAD4;EPAS1;TCF3;HNRNPAB;NEUROD1;TRIM28
transcription corepressor activityNR1H4;ZFPM1;HDAC4;MTA1;HDAC7A;THRB;ASXL1;LHX1;NCOR2
transcription factor bindingFOXA1;PBX2;CREBBP;HMGA1;TFDP1B;STK4;RARA;CD34;ETS1
contributes_to transcription regulatory region DNA bindingNFYC;ATF4;TCF12;RXRA;NFYA;HDAC5;NR1H3;TCF3;HDAC4
zinc ion bindingADH5;EWSR1;IRGF4;TAF2;NR2F6A;DDX58;PHF11;RNFT1;TRIM6

HDAC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC4.

YWHAG; YWHAZ; YWHAE; YWHAH

Wild, EJ; Tabrizi, SJ; et al. Targets for Future Clinical Trials in Huntington's Disease: What's in the Pipeline?. MOVEMENT DISORDERS 29:1434-1445(2014).
Hannan, JL; Kutlu, O; et al. Valproic Acid Prevents Penile Fibrosis and Erectile Dysfunction in Cavernous Nerve-Injured Rats. JOURNAL OF SEXUAL MEDICINE 11:1442-1451(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the impact of HDAC4 on cardiac hypertrophy and heart failure pathogenesis? 12/03/2022

HDAC4 affects cardiac hypertrophy and heart failure by regulating cardiac gene expression.

What are the mechanisms by which HDAC4 modulates immune responses and inflammation? 06/14/2022

HDAC4 regulates immune responses and inflammation through gene expression control.

What role does HDAC4 play in neuronal development and neurodegenerative diseases? 10/10/2020

HDAC4 is important for neuronal development and linked to neurodegenerative diseases.

How do environmental factors like stress and diet influence the activity and regulation of HDAC4? 03/29/2020

Stress and diet influence HDAC4 activity, affecting its role in gene regulation and cell processes.

How do mutations in the HDAC4 gene contribute to skeletal muscle development and related disorders? 03/16/2020

Mutations in HDAC4 disrupt skeletal muscle development and contribute to muscular disorders.

How does HDAC4 regulate gene expression through histone modification in different cell types? 04/01/2019

HDAC4 controls gene expression by altering histone acetylation, affecting chromatin structure.

How does HDAC4 interact with non-histone proteins and influence their function? 07/19/2018

HDAC4 interacts with non-histone proteins, influencing various cellular functions.

Customer Reviews (3)

Write a review
Reviews
04/29/2022

    Dependable protein-protein interaction assays; integral for our experiments.

    12/23/2021

      Efficient protein purification services; consistent yield and purity.

      12/19/2018

        Expertise in protein engineering; excellent service, highly recommended.

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