Recombinant Human HDAC4 protein(Met612-Leu1084)

• Cat.No.: HDAC4-518H
• Product Overview: Recombinant Human HDAC4 protein(NP_006028.2)(Met612-Leu1084) was expressed and purified in Insect Cells with two additional amino acids (Gly & Pro ) at the N-terminus.

Specification

• Source: Insect Cells
• Species: Human
• Tag: N/A
• Protein length: Met612-Leu1084
• Form: Lyophilized from sterile 20mM Tris,500mM NaCl, pH 7.4, 10%gly.
• Molecular Mass: The secreted recombinant human HDAC4 consists of 475 amino acids and predicts a molecular mass of 50.9 KDa. The apparent molecular mass of the protein is approximately 51 KDa in SDS-PAGE under reducing conditions due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
• Official Symbol: HDAC4
• Synonyms: HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; histone deacetylase A; AHO3; BDMR; HDAC-4; HDAC-A
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• UniProt ID: P56524

Reviews

04/29/2022

Dependable protein-protein interaction assays; integral for our experiments.

12/23/2021

Efficient protein purification services; consistent yield and purity.

12/19/2018

Expertise in protein engineering; excellent service, highly recommended.

Q&As

What is the impact of HDAC4 on cardiac hypertrophy and heart failure pathogenesis?

HDAC4 affects cardiac hypertrophy and heart failure by regulating cardiac gene expression.

What are the mechanisms by which HDAC4 modulates immune responses and inflammation?

HDAC4 regulates immune responses and inflammation through gene expression control.

What role does HDAC4 play in neuronal development and neurodegenerative diseases?

HDAC4 is important for neuronal development and linked to neurodegenerative diseases.

How do environmental factors like stress and diet influence the activity and regulation of HDAC4?

Stress and diet influence HDAC4 activity, affecting its role in gene regulation and cell processes.

How do mutations in the HDAC4 gene contribute to skeletal muscle development and related disorders?

Mutations in HDAC4 disrupt skeletal muscle development and contribute to muscular disorders.

How does HDAC4 regulate gene expression through histone modification in different cell types?

HDAC4 controls gene expression by altering histone acetylation, affecting chromatin structure.

How does HDAC4 interact with non-histone proteins and influence their function?

HDAC4 interacts with non-histone proteins, influencing various cellular functions.