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Recombinant Human HDAC4 Protein, GST-tagged

Cat.No. : HDAC4-022H
Product Overview : Recombinant Human HDAC4 protein (627-1085) with a N-terminal GST-tag was expressed in baculovirus expression system
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Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Source : Insect Cells
Species : Human
Tag : GST
Molecular Mass : 75.2 kDa
Protein length : 627-1085
Purity : 60% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, and 20 µM fluorogenic HDAC class 2a substrate.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 45 mM Tris-HCl, pH 8.0, with 124 mM NaCl, 2.4 mM KCl, 18 mM glutathione, and 10% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
Gene Name : HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]
Official Symbol : HDAC4
Synonyms : HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98
Gene ID : 9759
mRNA Refseq : NM_006037
Protein Refseq : NP_006028
MIM : 605314
UniProt ID : P56524

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of HDAC4 on cardiac hypertrophy and heart failure pathogenesis? 12/03/2022

HDAC4 affects cardiac hypertrophy and heart failure by regulating cardiac gene expression.

What are the mechanisms by which HDAC4 modulates immune responses and inflammation? 06/14/2022

HDAC4 regulates immune responses and inflammation through gene expression control.

What role does HDAC4 play in neuronal development and neurodegenerative diseases? 10/10/2020

HDAC4 is important for neuronal development and linked to neurodegenerative diseases.

How do environmental factors like stress and diet influence the activity and regulation of HDAC4? 03/29/2020

Stress and diet influence HDAC4 activity, affecting its role in gene regulation and cell processes.

How do mutations in the HDAC4 gene contribute to skeletal muscle development and related disorders? 03/16/2020

Mutations in HDAC4 disrupt skeletal muscle development and contribute to muscular disorders.

How does HDAC4 regulate gene expression through histone modification in different cell types? 04/01/2019

HDAC4 controls gene expression by altering histone acetylation, affecting chromatin structure.

How does HDAC4 interact with non-histone proteins and influence their function? 07/19/2018

HDAC4 interacts with non-histone proteins, influencing various cellular functions.

Customer Reviews (3)

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Reviews
04/29/2022

    Dependable protein-protein interaction assays; integral for our experiments.

    12/23/2021

      Efficient protein purification services; consistent yield and purity.

      12/19/2018

        Expertise in protein engineering; excellent service, highly recommended.

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