Recombinant Human HDAC4 Protein, GST-tagged HDAC4-022H

Recombinant Human HDAC4 Protein, GST-tagged

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Recombinant Human HDAC4 Protein, GST-tagged

HDAC4 Related Products

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Cat.No. : HDAC4-022H
Product Overview : Recombinant Human HDAC4 protein (627-1085) with a N-terminal GST-tag was expressed in baculovirus expression system
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Source : Insect Cells
Species : Human
Tag : GST
Molecular Mass : 75.2 kDa
Protein length : 627-1085
Purity : 60% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, and 20 µM fluorogenic HDAC class 2a substrate.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 45 mM Tris-HCl, pH 8.0, with 124 mM NaCl, 2.4 mM KCl, 18 mM glutathione, and 10% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE Analysis of HDAC4 :

Lane 1: MW Markers
Lane 2: HDAC4 (5 µg)

HDAC4 Deacetylase Activity :

Gene Name : HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]
Official Symbol : HDAC4
Synonyms : HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98
Gene ID : 9759
mRNA Refseq : NM_006037
Protein Refseq : NP_006028
MIM : 605314
UniProt ID : P56524

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