Recombinant Human HDAC4 Protein, GST-tagged


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Recombinant Human HDAC4 Protein, GST-tagged

HDAC4 Related Products

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Cat.No. : HDAC4-022H
Product Overview : Recombinant Human HDAC4 protein (627-1085) with a N-terminal GST-tag was expressed in baculovirus expression system
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Source : Insect Cells
Species : Human
Tag : GST
Molecular Mass : 75.2 kDa
Protein length : 627-1085
Purity : 60% estimated by SDS-PAGE
Unit Definition : One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.1 mg/ml BSA, and 20 µM fluorogenic HDAC class 2a substrate.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 45 mM Tris-HCl, pH 8.0, with 124 mM NaCl, 2.4 mM KCl, 18 mM glutathione, and 10% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE Analysis of HDAC4 :

Lane 1: MW Markers
Lane 2: HDAC4 (5 µg)

HDAC4 Deacetylase Activity :

Gene Name : HDAC4 histone deacetylase 4 [ Homo sapiens (human) ]
Official Symbol : HDAC4
Synonyms : HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; histone deacetylase 4; histone deacetylase A; EC
Gene ID : 9759
mRNA Refseq : NM_006037
Protein Refseq : NP_006028
MIM : 605314
UniProt ID : P56524
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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