Recombinant Human Distone Deacetylase 4, GST-tagged

• Cat.No.: HDAC4-1592H
• Product Overview: Recombinant human HDAC4 (612-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 612-end a.a.
• Description: HDAC4 or Histone Deacetylase 4 belongs to class II of the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. Binding of the N terminus of HDAC4 to MEF2C represses MEF2C transcription activity.
• Applications: HDAC Assay; Western Blot
• Molecular Weight: 77 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >95%
• Concentration: 0.1 ug/ul
• Specific Activity: 60 RLU/min/ng
• Sequences: 612-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Cell cycle; Endochondral Ossification; MicroRNAs in cardiomyocyte hypertrophy; Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class II; Signaling events mediated by HDAC Class III; Sumoylation by RanBP2 regulates transcriptional repression

Gene Information

• Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
• Official Symbol: HDAC4
• Synonyms: HDAC4; histone deacetylase 4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288; histone deacetylase 4; OTTHUMP00000164483; histone deacetylase A
• Gene ID: 9759
• mRNA Refseq: NM_006037
• Protein Refseq: NP_006028
• MIM: 605314
• UniProt ID: P56524
• Chromosome Location: 2q37
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; histone deacetylase binding; protein binding; protein deacetylase activity; repressing transcription factor binding; contributes_to sequence-specific DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding