hdac5
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  • Official Full Name
  • histone deacetylase 5
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9
Cat.#:HDAC5-312HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC5 Protein
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Cat.#:HDAC5-4647HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC5 Protein, GST-tagged
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Cat.#:Hdac5-1593MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Mouse Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-396HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-96HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HDAC5 Protein, His-tagged
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Cat.#:HDAC5-2055RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC5 Protein, His-tagged
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Cat.#:HDAC5-1358MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse HDAC5 (Active), GST-tagged
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Cat.#:HDAC5-5604HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC5 293 Cell Lysate
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Cat.#:Kit-1741Tag:
Source (Host):Species:
Product nameHDAC5 Fluorogenic Assay Kit
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Involved Pathway

HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST2H3A; GNGT1; HIST1H4F; H3F3A; HIST3H2A; HIST1H4D; HIST1H4L; GNB2; HIST1H3G; HIST1H2AL
B Cell Receptor Signaling Pathway
DUSP4; PPP3R2; PDK2B; RAP2A; RAC3; PIK3CA; NFKBIB; RAF1; MAP4K1; MAPK4
Cell cycle
RAD21A; VRK1; CLSPN; TGFB3; SPC24; DIDO1; VRK2; PMF1; MYC; ORC2
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
JAG2; HDAC5; HDAC6; CDK8; MIB1; ADAM10; CCNC; HEY2; JAG1; HEYL
Constitutive Signaling by NOTCH1 PEST Domain Mutants
JAG1; MIB1; JAG2; CCNC; HDAC5; HEY1; HEY2; HEYL; ADAM10; CDK8
Disease
PSTPIP2; AP2S1; gag; KREMEN2; CPSF4; WHSC2; FDX1; AP1G1; STX1B; STRA6
Diseases of signal transduction
STRA6; KREMEN2; FKBP1A; TRIM24; FGFR1OP2; RNF43; FGFR1OP; HEY1; HEY2; CCNC
Epstein-Barr virus infection
HLA-DRB3; PSMD4; CR2; PSMD11; SND1; NFKBIA; TBPL1; RIPK1; PSMD2; PLCG1

Protein Function

HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC3; HDAC7; HDAC10; HDAC9B; HDAC4; HDAC7A; HDAC1; HDAC2; HDAC9; HDAC8
Function RNA polymerase III transcription factor binding
Related Protein HDAC4; HDAC5
Function chromatin binding
Related Protein NCAPD3; EGFR; CHAF1B; JARID2; SOX9; SIRT7; ARID5A; HMGN5; TFAP2A; JUN
Function core promoter binding
Related Protein KDM3A; MYOG; IFI203; SFPQ; CCAR1; HDAC1; E2F2; INSM1A; INSM1B; AGO2
Function histone deacetylase activity
Related Protein HDAC8; HDAC9; HDAC3; HDAC5; HDAC7; HDAC10; HDAC4; HDAC1; MTA2; HDAC2
Function histone deacetylase binding
Related Protein SFPQ; NKX3-1; MEF2B; RELA; TCF21; SP1; NRIP1; ANKRA2; MEF2D; HIF1A
Function metal ion binding
Related Protein PPM1F; TPH1B; TRMT1; ZFP326; ZFP668; OSR2; ZNF394; ZDHHC22; CSGALNACT1; PDE6A
Function protein binding
Related Protein CHST13; LMO3; CFH; RPL39L; CCDC117; CD200; ZBED1; ACSF2; ADCYAP1; ZMYM4
Function protein deacetylase activity
Related Protein SIRT1; HDAC10; HDAC1; HDAC2; HDAC3; SIN3A; HDAC4; HDAC9; SIRT2; HDAC5
Function protein kinase C binding
Related Protein DSP; FLNA; AVPR1A; CASQ2; GRK5; GNB2L1; SDPRA; HAND2; PARD3; DACT2
Function repressing transcription factor binding
Related Protein HMGB1; CBX5; SKI; NOC2L; EIF4E; PRDM5; KAT5; TCF3; TLE4; HDAC5
Function transcription corepressor activity
Related Protein C1D; HSBP1; NEUROD2; FEV; APEX1; ZNF136; KDM5B; SKOR2; E2F8; SIRT1
Function transcription factor binding
Related Protein MSX2; FOXC1; PIK3R1; NR0B2A; HES4; BCOR; NLK; RORA; SIX2; HDAC5
Function contributes_to transcription regulatory region DNA binding
Related Protein RXRA; NFYC; TCF12; ATF4; TAF1; NFYB; HDAC5; NFYA; HDAC4; NR1H3

Interacting Protein

HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.
YWHAZ; SFN; YWHAB; YWHAE; ICP0; BRMS1; RUNX3

HDAC5 Related Articles

Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).
Maxwell, JT; Natesan, S; et al. Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 287:-(2012).