HDAC5 Protein, histone deacetylase 5


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Official Full Name histone deacetylase 5
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293 cells
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC5-312H Recombinant Human HDAC5 Protein HEK293 cells N/A
    Human HDAC5-48H Recombinant Human HDAC5 Protein, His-tagged Insect Cell His
    Human Hdac5-1593M Recombinant Mouse Histone Deacetylase 5, GST-tagged Sf9 Insect Cell GST
    Human HDAC5-396H Recombinant Human Histone Deacetylase 5, GST-tagged Insect Cell GST
    Human HDAC5-4647H Recombinant Human HDAC5 Protein, GST-tagged Wheat Germ GST
    Human HDAC5-5604HCL Recombinant Human HDAC5 293 Cell Lysate HEK293 N/A
    Human HDAC5-96H Recombinant Human HDAC5 Protein, His-tagged Insect Cell His
    Mouse HDAC5-1358M Recombinant Mouse HDAC5 (Active), GST-tagged Sf9 Insect Cell GST
    Rhesus Macaque HDAC5-2055R Recombinant Rhesus monkey HDAC5 Protein, His-tagged Mammalian Cell His
    Kit-1741 HDAC5 Fluorogenic Assay Kit N/A

    HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway ACTR3; IKBKG; PPP3CB; CDK7; LCP2A; SYK; CSK; BTK; Cd79a, Cd79b; GSK3AB
    Cell cycle BRCC3; MCM3; CSNK2A2; RCC2; E2F2; ORC2; NCAPG2; NCAPG; CSNK2B; CUL1A
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants ADAM10; CDK8; MIB1; CCNC; HDAC5; HEYL; JAG1; HEY1; JAG2; HEY2
    Constitutive Signaling by NOTCH1 PEST Domain Mutants HEY2; ADAM10; HDAC5; MIB1; HDAC6; JAG1; HEY1; CDK8; JAG2; HEYL
    Diseases of signal transduction CPSF6; KREMEN2; HEY1; TRIM24; OPN1LW; CDK8; FGFR1OP2; HEY2; CTBP2; TNKS2
    Epstein-Barr virus infection MAPK8; LYN; RELA; VIM; HLA-E; SPN; YWHAG; EIF2AK4; POLR3F; RAN

    HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC7; HDAC2; HDAC6; HDAC9B; HDAC1; HDAC7A; HDAC11; HDAC3; HDAC9; HDAC5
    RNA polymerase III transcription factor binding HDAC5; HDAC4
    chromatin binding CBX5; BAZ1B; RBMX; PDX1; WACA; NAP1L2; NKX2; NCOA2; SVEP1; ATXN7
    core promoter binding E2F8; NPAS2; MYOG; NOTCH1; KDM3A; SPI1; RB1; NKX2-1; MED1; SAFB
    histone deacetylase activity HDAC1; HDAC6; MTA2; HDAC5; ATXN3L; HDAC8; HDAC2; HDAC10; HDAC9; HDAC7
    histone deacetylase binding ANKRD1; CBX5; RFXANK; CDC20; PRDM1; DHX36; GLI3; HOXA10; BRMS1L; YWHAE
    metal ion binding PFKMA; NANOS1; ZNF7; NPEPPS; CAR3; ZNF740; ENDOG; BTR18; RXRBB; SCRT2
    protein binding BEX2; CXorf41; KRT18; CHN1; SDC4; HILPDA; CBX6; NTRK3; PHAX; GPS1
    protein deacetylase activity SIRT1; SIN3A; HDAC4; HDAC2; HDAC10; HDAC9; HDAC1; SIRT2; HDAC3; HDAC5
    protein kinase C binding SDPR; PAWR; AKT2; SDPRA; PRKCSH; DACT3; PLEK; HAND2; SDPRB; TRPV4
    repressing transcription factor binding EIF4E; MYC; DDX20; TBP; PARK7; GMNN; KAT5; HDAC9; HDAC4; HMGB1
    transcription corepressor activity SETD8; TSG101; RLIM; E4F1; SAP30; YY1; AEBP2; YAF2; NSD1; HDAC4
    transcription factor binding FIGLA; HDAC5; HTT; NAB1; KCNA3; NLRP3; RNF4; WWP2; BCOR; SNF8
    contributes_to transcription regulatory region DNA binding NFYA; RXRA; TCF12; HAND1; NFYC; TAF1; NR1H3; HDAC4; ATF4; TCF3

    HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.


    Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).
    Maxwell, JT; Natesan, S; et al. Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 287:-(2012).

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