HDAC5
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Official Full Name
histone deacetylase 5
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Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293 cells
- Insect cell
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HDAC5 Related Articles
- HDAC5 Related Research Area
- HDAC5 Related Signal Pathway
HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alcoholism | CRH;HIST1H3H;HIST1H2BB;HIST2H2BE;HIST1H3A;H3F3B;HIST1H4G;GRIN2A;HIST1H4K |
B Cell Receptor Signaling Pathway | HRAS;IFITM1;RAF1;CRKL;TTC6;MAPK1;ITK;PLEKHA2;ITPR2 |
Cell cycle | NUP50;CSNK1E;GADD45B;ENSAA;CCNE1;CENPP;ORC4L;TEX15;ZBTB17 |
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | CCNC;MIB1;JAG1;HEY2;CDK8;ADAM10;JAG2;HEYL;HDAC5 |
Constitutive Signaling by NOTCH1 PEST Domain Mutants | MIB1;JAG2;HEY1;HDAC6;HDAC5;ADAM10;CCNC;CDK8;JAG1 |
Disease | NUP50;PPIA;TIRAP;CDK9;RLBP1;SUPT4H1;AP1S1;STX1B;MTRR |
Diseases of signal transduction | HEY1;CDC37;STRA6;RBP1;KREMEN2;LRRFIP1;JAG1;TNKS2;RNF43 |
Epstein-Barr virus infection | HLA-DPB1;SHFM1;NUP214;HSPA1B;HLA-DRA;AKT1;RIPK1;HLA-F;PSMD13 |
HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.
Function | Related Protein |
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NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC8;HDAC9B;HDAC3;HDAC11;HDAC2;HDAC10;HDAC5;HDAC7A;HDAC6 |
RNA polymerase III transcription factor binding | HDAC4;HDAC5 |
chromatin binding | UBTF;PAX3;PPARGC1A;CREBBP;KAT2B;YBX1;ATAD2B;SHMT2;RNF20 |
core promoter binding | HNRNPU;HDAC4;EP300;KLF4;SFPI1;MYOG;E2F3;GTF2B;RBMX |
histone deacetylase activity | HDAC9B;HDAC6;SIRT1;HDAC2;HDAC5;HDAC9;HDAC11;MTA2;HDAC7 |
histone deacetylase binding | TCF21;CRY1;NRIP1;FOXP3;MAPK8;HIST1H1B;YY1;HDAC9;MEF2A |
metal ion binding | ZNF100;AGBL4;ADAMTS16;ZNF180;ZFAND5B;TRIM35-24;ZNF726;ZFP354B;GALNTL1 |
protein binding | PPFIA4;INTS9;TXNDC12;EDA;BAG4;SKA3;OLFM3;HMGB1;PPP3R1 |
protein deacetylase activity | SIRT1;HDAC4;HDAC3;SIN3A;HDAC2;SIRT2;HDAC9;HDAC5;HDAC10 |
protein kinase C binding | GRK5;SDC4;HDAC7A;HDAC5;HDAC7;SDPR;PKN1;UGT1A7;SDPRA |
repressing transcription factor binding | PRDM5;TBP;CTBP1;DDX20;HDAC1;NOC2L;RELA;KAT5;PARK7 |
transcription corepressor activity | MTA1;TBL1Y;MAP3K10;NR1H4;ATF3;GMNN;HAND1;ZFPM1;ZHX3 |
transcription factor binding | DIP2B;PURA;ATOH8;NLRP3;APBB2;MECP2;SMARCD3;BCOR;NFYC |
contributes_to transcription regulatory region DNA binding | NFYB;NFYC;HDAC4;HDAC5;NR1H3;ATF4;TCF12;TAF1;NFYA |
HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.
YWHAZ; SFN; YWHAB; YWHAE; ICP0; BRMS1; RUNX3
- Q&As
- Reviews
Q&As (6)
Ask a questionIt has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.
This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.
HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.
The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.
HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.
This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.
Customer Reviews (3)
Write a reviewThe HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.
It performs well in ELISA and is very suitable for immunoassays.
It has strong antibacterial activity and is not easy to be contaminated.
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