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HDAC5

  • Official Full Name

    histone deacetylase 5

  • Overview

    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293 cells
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDAC5-396H Active Recombinant Human Histone Deacetylase 5, GST-tagged Insect Cell GST
Human HDAC5-96H Active Recombinant Human HDAC5 Protein, His-tagged Insect Cell His 476 amino acids
Human HDAC5-4647H Recombinant Human HDAC5 Protein, GST-tagged Wheat Germ GST
Human Hdac5-1593M Recombinant Mouse Histone Deacetylase 5, GST-tagged Sf9 Insect Cell GST
Human HDAC5-5604HCL Recombinant Human HDAC5 293 Cell Lysate HEK293 N/A
Human HDAC5-2638H Recombinant Human HDAC5 Protein (681-1087), His tagged E.coli His 681-1087
Human HDAC5-164H Recombinant Human HDAC5 Protein, His-tagged Insect cell His
Human HDAC5-48H Recombinant Human HDAC5 Protein, His-tagged Insect Cell His 657-1,123
Human HDAC5-312H Active Recombinant Human HDAC5 Protein HEK293 cells N/A amino acids 679-1095
Human HDAC5-2637H Recombinant Human HDAC5 Protein (Phe681-Ser1087), N-His tagged E.coli N-His Phe681-Ser1087
Mouse HDAC5-1358M Active Recombinant Mouse HDAC5, GST-tagged Sf9 Insect Cell GST 617 aa-end
Rhesus Macaque HDAC5-2055R Recombinant Rhesus monkey HDAC5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HDAC5-1876R Recombinant Rhesus Macaque HDAC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HDAC5-1876R-B Recombinant Rhesus Macaque HDAC5 Protein Pre-coupled Magnetic Beads HEK293
Kit-1741 HDAC5 Fluorogenic Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDAC5 Related Articles
  • HDAC5 Related Research Area
  • HDAC5 Related Signal Pathway

HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismCRH;HIST1H3H;HIST1H2BB;HIST2H2BE;HIST1H3A;H3F3B;HIST1H4G;GRIN2A;HIST1H4K
B Cell Receptor Signaling PathwayHRAS;IFITM1;RAF1;CRKL;TTC6;MAPK1;ITK;PLEKHA2;ITPR2
Cell cycleNUP50;CSNK1E;GADD45B;ENSAA;CCNE1;CENPP;ORC4L;TEX15;ZBTB17
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsCCNC;MIB1;JAG1;HEY2;CDK8;ADAM10;JAG2;HEYL;HDAC5
Constitutive Signaling by NOTCH1 PEST Domain MutantsMIB1;JAG2;HEY1;HDAC6;HDAC5;ADAM10;CCNC;CDK8;JAG1
DiseaseNUP50;PPIA;TIRAP;CDK9;RLBP1;SUPT4H1;AP1S1;STX1B;MTRR
Diseases of signal transductionHEY1;CDC37;STRA6;RBP1;KREMEN2;LRRFIP1;JAG1;TNKS2;RNF43
Epstein-Barr virus infectionHLA-DPB1;SHFM1;NUP214;HSPA1B;HLA-DRA;AKT1;RIPK1;HLA-F;PSMD13

HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.

Function Related Protein
NAD-dependent histone deacetylase activity (H3-K14 specific)HDAC8;HDAC9B;HDAC3;HDAC11;HDAC2;HDAC10;HDAC5;HDAC7A;HDAC6
RNA polymerase III transcription factor bindingHDAC4;HDAC5
chromatin bindingUBTF;PAX3;PPARGC1A;CREBBP;KAT2B;YBX1;ATAD2B;SHMT2;RNF20
core promoter bindingHNRNPU;HDAC4;EP300;KLF4;SFPI1;MYOG;E2F3;GTF2B;RBMX
histone deacetylase activityHDAC9B;HDAC6;SIRT1;HDAC2;HDAC5;HDAC9;HDAC11;MTA2;HDAC7
histone deacetylase bindingTCF21;CRY1;NRIP1;FOXP3;MAPK8;HIST1H1B;YY1;HDAC9;MEF2A
metal ion bindingZNF100;AGBL4;ADAMTS16;ZNF180;ZFAND5B;TRIM35-24;ZNF726;ZFP354B;GALNTL1
protein bindingPPFIA4;INTS9;TXNDC12;EDA;BAG4;SKA3;OLFM3;HMGB1;PPP3R1
protein deacetylase activitySIRT1;HDAC4;HDAC3;SIN3A;HDAC2;SIRT2;HDAC9;HDAC5;HDAC10
protein kinase C bindingGRK5;SDC4;HDAC7A;HDAC5;HDAC7;SDPR;PKN1;UGT1A7;SDPRA
repressing transcription factor bindingPRDM5;TBP;CTBP1;DDX20;HDAC1;NOC2L;RELA;KAT5;PARK7
transcription corepressor activityMTA1;TBL1Y;MAP3K10;NR1H4;ATF3;GMNN;HAND1;ZFPM1;ZHX3
transcription factor bindingDIP2B;PURA;ATOH8;NLRP3;APBB2;MECP2;SMARCD3;BCOR;NFYC
contributes_to transcription regulatory region DNA bindingNFYB;NFYC;HDAC4;HDAC5;NR1H3;ATF4;TCF12;TAF1;NFYA

HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.

YWHAZ; SFN; YWHAB; YWHAE; ICP0; BRMS1; RUNX3

Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).
Maxwell, JT; Natesan, S; et al. Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 287:-(2012).
  • Q&As
  • Reviews

Q&As (6)

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Is there a relationship between HDAC5 and neurological diseases? 11/26/2022

It has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.

What is the link between HDAC5 and cardiovascular disease? 04/17/2022

This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.

What is the relationship between HDAC5 and disease? 04/17/2022

HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.

How is HDAC5 activity regulated? 02/08/2021

The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.

Do HDAC5 inhibitors have a role in treatment? 07/07/2020

HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.

Which role of HDAC5 in cancer? 01/21/2020

This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.

Customer Reviews (3)

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Reviews
02/22/2022

    The HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.

    12/22/2021

      It performs well in ELISA and is very suitable for immunoassays.

      02/13/2020

        It has strong antibacterial activity and is not easy to be contaminated.

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