HIF1A
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Official Full Name
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
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Overview
Hypoxia, a condition of low tissue O2 concentration, plays an important role in normal physiological processes and tumor formation. Under hypoxic conditions mammalian cells up regulate the expression of hypoxic genes, including induction of angiogenesis and a switch to anaerobic metabolism, in order to survive. HIF-1 (Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is composed of two subunits, HIF-1alphaand HIF-1beta also known as aryl hydrocarbon receptor nuclear translocator (ARNT)) that are members of the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) (bHLH-PAS) family of transcription factors. HIF-1 is essential for angiogenesis, embryonic development, and is associated with tumor progression, erythropoiesis, vascular development/remodeling, vasodilation, and glucose/energy metabolism. The over expression of HIF-1alphahas been demonstrated in many common human cancers including prostate and breast, in which HIF-1alpha levels are associated with increase vascularitry and tumor progression. Besides physiological hypoxia, genetic abnormalities frequently detected in human cancers, such as loss of function mutations (Von Hippel-Lindau, p53, and PTEN), are associated with induction of HIF1 activity and expression of HIF-1-inducible genes (1). -
Synonyms
HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; bHLHe78; HIF 1alpha; HIF1; MOP1; PASD8; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF-1alpha; HIF1-ALPHA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
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- E. coli
- E.coli
- HEK293
- Human
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Strep
- His|GST
- His|MBP
- His|S
- N/A
- N
- No tag
- T7
- TEV
- Involved Pathway
- Protein Function
- Interacting Protein
- HIF1A Related Articles
- HIF1A Related Research Area
HIF1A involved in several pathways and played different roles in them. We selected most pathways HIF1A participated on our site, such as HIF- signaling pathway, mTOR signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HIF- signaling pathway | PFKFB3;IGF1;PIK3CB;ENO2;IFNGR2;RPS6;PGK1;TFRC;MAP2K2 |
mTOR signaling pathway | RPS6KAL;INSB;PIK3CG;AKT1;RRAGC;PTENB;TSC1;RPS6;EIF4BA |
Thyroid hormone signaling pathway | PLCB3;NOTCH4;RXRG;KRAS;MED24;ATP1B3;CCND1;DIO3;CASP9 |
Pathways in cancer | LAMA2;MAPK9;RUNX1;WNT7B;LPAR5;GSK3B;PIK3R2;TFG;SMAD3 |
Proteoglycans in cancer | FZD5;RPS6;GRB2;FGFR1;TIMP3;ACTB;WNT5B;PDCD4;ESR1 |
Renal cell carcinoma | PAK1;EGLN2;AKT2;HIF1A;TCEB2;EPAS1;TGFB1;FH1;VEGFA |
Central carbon metabolism in cancer | HK2;PDK1;SIRT3;LDHA;IDH1;PIK3CB;GLS;PIK3R1;PDGFRA |
Choline metabolism in cancer | DGKG;RAC1;PPAP2B;PIP5K1B;PIK3CD;DGKZ;DGKQ;PDPK1;TSC1 |
HIF1A has several biochemical functions, for example, Hsp90 protein binding, enzyme binding, histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIF1A itself. We selected most functions HIF1A had, and list some proteins which have the same functions with HIF1A. You can find most of the proteins on our site.
Function | Related Protein |
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Hsp90 protein binding | HIF1A;CDC37;TELO2;AHR;RPS3;ERBB2;UNC45A;EIF2AK3;ERN1 |
enzyme binding | CD4;MLL5;PLSCR1;PTEN;DDX5;SIRT3;PEX5;MAPK14;HAND2 |
histone acetyltransferase binding | EID1;CEBPB;HIF1A;CITED2;PCNA;TRIP4;SP1;EGR1;TAF7 |
histone deacetylase binding | CDC20;BRMS1L;ZNHIT1;HDAC10;MAGEA1;TFAP4;RAD9;CEBPB;HES1 |
nuclear hormone receptor binding | CTNNB1;NRIP1;MED1;NCOA3;NCOR1;CRY1;NCOA1;HIF1A;Ankar |
protein binding | USP22;RBBP5;LDHA;ALDOC;MAPRE3;GRB10;GBP2;CSDE1;IRF3 |
protein heterodimerization activity | H3F3C;SMAD1;HIST1H2BI;NKX2;PRMT5;POLA1;CLCN3;TAF9B;DMRT1 |
protein kinase binding | B4GALT1;SPAG16;FGF19;FBXO5;CALM;MAP3K12;FGR;TELO2;MAPK6 |
contributes_to sequence-specific DNA binding | SMAD4;HIF1A;TCF3;HNRNPAB;NEUROD1;TRIM28;HDAC4;FIGLA;EPAS1 |
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | CIR1;PTH;ATF2;SOX9;GTF2IRD1;T;USF2;PDX1;RELA |
contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | ARNT;HIF1A |
transcription factor activity, RNA polymerase II transcription factor binding | MYOCD;NACC2;GATA4;SMAD4;TWIST2;ZNF296;THRAA;HIF1A;MAMSTR |
transcription factor activity, sequence-specific DNA binding | TGIF2;SCAND1;DMRTA1;HOXA5A;STAT5A;PA2G4;RARAA;TBX22;TBX19 |
transcription factor activity, transcription factor binding | ASCL1A;HIF1A;LDB1B;NEUROG1;LDB1A;ASCL1B;TP63;TRP63;FOXO1 |
transcription factor binding | KDM1A;EGR1;IRF4;GATA3;TBX5;CEBPA;WWP2;PURA;PRKDC |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFKB2;FLI1;ATF2;SOX2;MYOCD;MEOX1;FOXK2;OTX2;PATZ1 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MYOG;HOXD8;REST;MSX1;GRHL3;SOHLH1;NHLH1;TRP53;PAX9 |
ubiquitin protein ligase binding | YWHAZ;MFN2;TRIOBP;DTX1;RNF20;NKD2;TRIB1;LRPPRC;PML |
HIF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIF1A.
VHL
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Q&As (7)
Ask a questionHIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.
HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.
HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.
In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.
HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.
Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.
Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.
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