Recombinant Human HIF1A

• Cat.No.: HIF1A-640H
• Product Overview: Recombinant Human HIF1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Human
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Homo sapiens ]
• Official Symbol: HIF1A
• Gene ID: 3091
• mRNA Refseq: NM_001243084.1
• Protein Refseq: NP_001230013.1
• MIM: 603348
• UniProt ID: C0LZJ3

Reviews

03/19/2022

Reliable product, satisfied customer.

03/28/2021

Good value for money.

11/07/2018

Product exceeded expectations.

Q&As

How does HIF1A contribute to metabolic reprogramming in cells?

HIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.

How does HIF1A influence immune responses under hypoxic conditions?

HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.

What role does HIF1A play in angiogenesis?

HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.

In what way is HIF1A implicated in cancer progression?

In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.

What is the primary function of HIF1A in response to hypoxia?

HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.

How is HIF1A regulated at the post-translational level?

Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.

What therapeutic strategies are being developed to target HIF1A in diseases?

Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.