hspb8
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  • Official Full Name
  • heat shock 22kDa protein 8
  • Background
  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
  • Synonyms
  • HSPB8; heat shock 22kDa protein 8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; heat shock protein beta-8; OTTHUMP00000239768; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22
Cat.#:HSPB8-5120HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSPB8 Protein, GST-tagged
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Cat.#:HSPB8-1254HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Heat Shock 22kDa Protein 8
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Cat.#:HSPB8-165HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPB8 protein, His/MBP-tagged
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Cat.#:HSPB8-2025HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Heat Shock 22kDa Protein 8, His-tagged
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Cat.#:HSPB8-27526THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPB8, His-tagged
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Cat.#:HSPB8-29389THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPB8
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Cat.#:HSPB8-7919MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HSPB8 Protein
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Cat.#:HSPB8-2954RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSPB8 Protein
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Cat.#:HSPB8-2170RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HSPB8 Protein, His-tagged
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Cat.#:HSPB8-5907ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HSPB8
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Cat.#:HSPB8-5345HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HSPB8 293 Cell Lysate
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Protein Function

HSPB8 has several biochemical functions, for example, identical protein binding, protein binding, NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPB8 itself. We selected most functions HSPB8 had, and list some proteins which have the same functions with HSPB8. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein DYNLT1F; APLP1; PITX2; ESR1; PARP1; CSK; ZNF212; GOT1L1; CSNK2B; IK
Function protein binding
Related Protein DAK; KIF20A; KLHL7; SEMA3E; BDKRB1; NEK9; CD200R2; GAS7; EDARADD; PTTG1IP
Function NOT protein kinase activity
Related Protein STRADA; HSPB8; TRIB2; STRADB; MLKL; TRIB1; PXK

Interacting Protein

HSPB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPB8.
HSPB7; BAG3; HSPB2

HSPB8 Related Articles

Tao, X; Lu, W; et al. HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. NEUROLOGICAL RESEARCH 37:229-237(2015).
Giorgetti, E; Rusmini, P; et al. Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy. HUMAN MOLECULAR GENETICS 24:64-75(2015).