HSPB8
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Official Full Name
heat shock 22kDa protein 8 -
Overview
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. -
Synonyms
HSPB8;heat shock 22kDa protein 8;H11;HMN2;CMT2L;DHMN2;E2IG1;HMN2A;HSP22;heat shock protein beta-8;OTTHUMP00000239768;protein kinase H11;alpha-crystallin C chain;E2-induced gene 1 protein;heat shock 27kDa protein 8;small stress protein-like protein HSP22
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Non
- His
- MBP
- GST
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
HSPB8 involved in several pathways and played different roles in them. We selected most pathways HSPB8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HSPB8 has several biochemical functions, for example, identical protein binding,protein binding,NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPB8 itself. We selected most functions HSPB8 had, and list some proteins which have the same functions with HSPB8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | ZHX2,GRIN3A,ABCD1,TRIM5,ZNF703,VWF,NLRC4,CNTN2,PSME3,SHARPIN |
| protein binding | FOXP1,SNRPB2,KRT38,NMNAT1,ARHGEF12,ZMAT2,ITGB1BP2,CNOT3,ZNF238,MIS12 |
| NOT protein kinase activity | PXK,STRADB,STRADA,MLKL,TRIB2,TRIB1 |
Interacting Protein
HSPB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPB8.
HSPB7;BAG3;HSPB2
Resources
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References
- Tao, X; Lu, W; et al. HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. NEUROLOGICAL RESEARCH 37:229-237(2015).
- Giorgetti, E; Rusmini, P; et al. Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy. HUMAN MOLECULAR GENETICS 24:64-75(2015).
