htra1
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  • Official Full Name
  • HtrA serine peptidase 1
  • Background
  • This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
  • Synonyms
  • HTRA1; HtrA serine peptidase 1; protease, serine, 11 (IGF binding) , PRSS11; serine protease HTRA1; HtrA; IGFBP5 protease; IGFBP5-protease; protease, serine, 11 (IGF binding); high-temperature requirement A serine peptidase 1; L56; ARMD7; ORF480; PRSS11
Cat.#:HTRA1-2578MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse HTRA1 Protein (141-480 aa), His-tagged
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Cat.#:HTRA1-5230HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HTRA1 Protein, GST-tagged
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Cat.#:HTRA1-1859HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA1 protein, His & GST-tagged
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Cat.#:HtrA1-2890HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HtrA1, His-tagged
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Cat.#:HTRA1-47HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HTRA1, His-tagged
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Cat.#:HTRA1-660HTag:Myc|DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HTRA1 Protein, MYC/DDK-tagged
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Cat.#:HTRA1-7942MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HTRA1 Protein
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Cat.#:HTRA1-2972RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HTRA1 Protein
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Cat.#:HTRA1-2177RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HTRA1 Protein, His-tagged
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Cat.#:HTRA1-2015HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HtrA Serine Peptidase 1, His-tagged
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Cat.#:HtrA1-2889HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HtrA1, Truncated, His-tagged
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Cat.#:HTRA1-2891HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA1, His-tagged
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Cat.#:HTRA1-5329HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HTRA1 293 Cell Lysate
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Protein Function

HTRA1 has several biochemical functions, for example, insulin-like growth factor binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA1 itself. We selected most functions HTRA1 had, and list some proteins which have the same functions with HTRA1. You can find most of the proteins on our site.
Function
Related Protein
Function insulin-like growth factor binding
Related Protein HTRA3; IGFBP2B; CYR61L1; IGFBP3; IGFBP6B; ESM1; NOV; IGF1RB; IGFBP5B; HTRA1B
Function serine-type endopeptidase activity
Related Protein PRSS59.2; F12; PRSS2; MMP8; ELA2; CTSC; PLAUA; PRSS27; TMPRSS11E; LOC780933
Function serine-type peptidase activity
Related Protein KLK1B26; PRSS8; PRSS52; PREP; DPP9; TMPRSS13A; KLK15; EGFBP2; SLC38A8; HTRA1

Interacting Protein

HTRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA1.
IMPDH1; NOS3; CSNK2B; FAM46A; yibD; GRB2; GOLT1B

HTRA1 Related Articles

Sohn, EH; Wang, K; et al. COMPARISON OF DRUSEN AND MODIFYING GENES IN AUTOSOMAL DOMINANT RADIAL DRUSEN AND AGE-RELATED MACULAR DEGENERATION. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 35:48-57(2015).
Zielonka, S; Weber, N; et al. Shark Attack: High affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. JOURNAL OF BIOTECHNOLOGY 191:236-245(2014).