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HTRA1

  • Official Full Name

    HtrA serine peptidase 1

  • Overview

    This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
  • Synonyms

    HTRA1; HtrA serine peptidase 1; protease, serine, 11 (IGF binding) , PRSS11; serine protease HTRA1; HtrA; IGFBP5 protease; IGFBP5-protease; protease, serine, 11 (IGF binding); high-temperature requirement A serine peptidase 1; L56; ARMD7; ORF480; PRSS11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • SUMO
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTRA1-2891H Active Recombinant Human HTRA1, His-tagged E.coli His
Human HTRA1-47H Recombinant Human HTRA1, His-tagged Sf9 Insect Cell His
Human HtrA1-2890H Recombinant Human HtrA1, His-tagged Insect Cell His
Human HTRA1-2015H Recombinant Human HtrA Serine Peptidase 1, His-tagged Insect Cell His
Human HtrA1-2889H Recombinant Human HtrA1, Truncated, His-tagged E.coli His
Human HTRA1-660H Recombinant Human HTRA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HTRA1-5329HCL Recombinant Human HTRA1 293 Cell Lysate HEK293 N/A
Human HTRA1-1125H Recombinant Human HTRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HTRA1-090H Recombinant Human HTRA1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HTRA1-3172H Recombinant Human HTRA1 Protein (Gly204-Leu364), N-His tagged E.coli N-His Gly204-Leu364
Human HTRA1-128H Recombinant Human HTRA1 Mutant (K346I) Protein, Myc/DDK-tagged HEK293 Myc/DDK 161-369
Human HTRA1-1125H-B Recombinant Human HTRA1 Protein Pre-coupled Magnetic Beads HEK293
Human HTRA1-129H Recombinant Human HTRA1 Mutant (R310A, E306A) Protein, Myc/DDK-tagged HEK293 Myc/DDK 161-369
Human HTRA1-1859H Recombinant Human HTRA1 protein, His & GST-tagged E.coli His/GST Gly204~Leu364
Human HTRA1-19HFL Active Recombinant Full Length Human HTRA1 Protein, C-Flag-tagged Mammalian cells Flag
Human HTRA1-5230H Recombinant Human HTRA1 Protein, GST-tagged Wheat Germ GST
Human HTRA1-131H Recombinant Human HTRA1 Mutant (R302A) Protein, Myc/DDK-tagged HEK293 Myc/DDK 161-369
Human HTRA1-130H Recombinant Human HTRA1 Mutant (S328A) Protein, Myc/DDK-tagged HEK293 Myc/DDK 161-369
Human HTRA1-132H Recombinant Human HTRA1 Mutant (L345G) Protein, Myc/DDK-tagged HEK293 Myc/DDK 161-369
Human HTRA1-4654H Recombinant Human HTRA1 protein, His-SUMO-tagged E.coli His-SUMO 23-480aa
Human HTRA1-5712HF Recombinant Full Length Human HTRA1 Protein, GST-tagged In Vitro Cell Free System GST 447 amino acids
Mouse HTRA1-7942M Recombinant Mouse HTRA1 Protein Mammalian Cell His
Mouse HTRA1-2578M Recombinant Mouse HTRA1 Protein (141-480 aa), His-tagged E.coli His 141-480 aa
Mouse Htra1-3462M Recombinant Mouse Htra1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HTRA1-4381M-B Recombinant Mouse HTRA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HTRA1-4381M Recombinant Mouse HTRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HTRA1-2972R Recombinant Rat HTRA1 Protein Mammalian Cell His
Rat HTRA1-2627R Recombinant Rat HTRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HTRA1-2627R-B Recombinant Rat HTRA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HTRA1-2177R Recombinant Rhesus monkey HTRA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HTRA1-1998R Recombinant Rhesus Macaque HTRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HTRA1-1998R-B Recombinant Rhesus Macaque HTRA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTRA1 Related Articles
  • HTRA1 Related Research Area

HTRA1 involved in several pathways and played different roles in them. We selected most pathways HTRA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HTRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

HTRA1 has several biochemical functions, for example, insulin-like growth factor binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA1 itself. We selected most functions HTRA1 had, and list some proteins which have the same functions with HTRA1. You can find most of the proteins on our site.

Function Related Protein
insulin-like growth factor bindingCYR61L1;WISP1B;IGFBP2A;CYR61;DEFB126;HTRA4;KAZALD2;IGF1RA;IGFBP5A
serine-type endopeptidase activityF2;HTRA1A;GZMF;TPP2;PRSS50;TPP1;HTRA3;PRSS41;GM5077
serine-type peptidase activityPRSS59.2;MCPT9;PREP;PLAUB;PRSS16;ST14A;Reln;DPP4;C1R

HTRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA1.

IMPDH1; NOS3; CSNK2B; FAM46A; yibD; GRB2; GOLT1B

Sohn, EH; Wang, K; et al. COMPARISON OF DRUSEN AND MODIFYING GENES IN AUTOSOMAL DOMINANT RADIAL DRUSEN AND AGE-RELATED MACULAR DEGENERATION. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 35:48-57(2015).
Zielonka, S; Weber, N; et al. Shark Attack: High affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. JOURNAL OF BIOTECHNOLOGY 191:236-245(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between the structure and function of HTRA1 protein? 05/26/2023

The structure of the HTRA1 protein determines its function. The serine protease domain is the main functional region of HTRA1 protein, which has catalytic activity and can degrade proteins. In addition, the HTRA1 protein has a number of different domains that are closely related to its function.

Describe the treatment strategy of HTRA1 protein? 09/16/2022

Therapeutic strategies for HTRA1 protein include inhibiting its activity, regulating its expression level, and altering its structure. Several drugs are already undergoing clinical trials to evaluate their efficacy against cancer and other diseases.

How can disease be treated by regulating the expression of HTRA1 protein? 10/28/2021

There are currently no treatments that directly regulate HTRA1 protein expression. However, some diseases can be treated by inhibiting their activity or regulating their expression levels. For example, some drugs can inhibit the activity of the HTRA1 protein to treat cancer or Alzheimer's disease.

Is HTRA1 involved in cell signal transduction? 08/03/2021

HTRA1 protein can be used as a signal transduction molecule by binding to receptors on the cell surface to transmit signals to the cell interior and participate in cell proliferation, differentiation and apoptosis.

How does HTRA1 protein participate in extracellular matrix remodeling? 07/24/2021

This protein can degrade a variety of proteins in the extracellular matrix, including collagen, elastin and fibrin, and thus participate in extracellular matrix remodeling.

What method is used to detect the expression level of HTRA1 protein in biological samples? 06/15/2021

The expression level of HTRA1 protein in biological samples can be detected by immunohistochemistry, western blot and real-time quantitative PCR.

Customer Reviews (3)

Write a review
Reviews
06/06/2022

    The structure of HTRA1 is stable and not easy to mutate, which ensures the reliability of the experimental results.

    08/17/2021

      The solubility and ion exchange capacity are very good, which is convenient for subsequent experimental processing and purification.

      11/10/2020

        It is easy to operate and does not require complex operation steps.

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