Active Recombinant Full Length Human HTRA1 Protein, C-Flag-tagged

• Cat.No.: HTRA1-19HFL
• Product Overview: Recombinant Full Length Human HTRA1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Protein degradation enzyme
  Enzyme activity
• Molecular Mass: 49 kDa
• AA Sequence: MQIPRAALLPLLLLLLAAPASAQLS RAGRSAPLAAGCPDRCEPARCPPQP EHCEGGRARDACGCCEVCG APEGAACGLQEGPCGEGLQCVVPFG VPASATVRRRAQAGLCVCASSEPVC GSDANTYANLCQLRAASRR SERLHRPPVIVLQRGACGQGQEDPN SLRHKYNFIADVVEKIAPAVVHIEL FRKLPFSKREVPVASGSGF IVSEDGLIVTNAHVVTNKHRVKVEL KNGATYEAKIKDVDEKADIALIKID HQGKLPVLLLGRSSELRPG EFVVAIGSPFSLQNTVTTGIVSTTQ RGGKELGLRNSDMDYIQTDAIINYG NSGGPLVNLDGEVIGINTL KVTAGISFAIPSDKIKKFLTESHDR QAKGKAITKKKYIGIRMMSLTSSKA KELKDRHRDFPDVISGAYI IEVIPDTPAEAGGLKENDVIISING QSVVSANDVSDVIKRESTLNMVVRR GNEDIMITVIPEEIDP
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein

Gene Information

• Gene Name: HTRA1 HtrA serine peptidase 1 [ Homo sapiens (human) ]
• Official Symbol: HTRA1
• Synonyms: L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; CADASIL2
• Gene ID: 5654
• mRNA Refseq: NM_002775.5
• Protein Refseq: NP_002766.1
• MIM: 602194
• UniProt ID: Q92743