igf2r
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  • Official Full Name
  • Insulin-like Growth Factor 2 Receptor
  • Background
  • The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
  • Synonyms
  • cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR1; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; CD222 antigen; MPRI; CD222; CIMPR; M6P-R; IGF2R; insulin-like growth factor 2 receptor
Cat.#:IGF2R-29238THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2R, His-tagged
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Cat.#:IGF2R-611HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human IGF2R, His-tagged
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Cat.#:IGF2R-625HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human IGF2R, Fc-tagged, Biotinylated
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Cat.#:IGF2R-626HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human IGF2R, Fc-tagged
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Cat.#:IGF2R-677HTag:HIS
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IGF2R, His-tagged
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Cat.#:IGF2R-8069MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IGF2R Protein
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Cat.#:Igf2r-849MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igf2r protein, His-tagged
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Cat.#:Igf2r-1729RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igf2r protein, His & T7-tagged
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Cat.#:IGF2R-6529CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF2R
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Cat.#:IGF2R-3631ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGF2R
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Cat.#:IGF2R-619HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 2 Receptor
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Involved Pathway

IGF2R involved in several pathways and played different roles in them. We selected most pathways IGF2R participated on our site, such as Lysosome, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysosome
GM2A; ATP6AP1B; ACP5; AP1M1; NPC1; CTSE; CTSSB.2; ASAH1A; ATP6V0A4; SLC11A1
Endocytosis
CHMP1B; HSP70; CAPZA3; MHC1UXA2; FLT1; GRK5; GIT2; CAPZB; AGAP1; CHMP7

Protein Function

IGF2R has several biochemical functions, for example, glycoprotein binding, identical protein binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2R itself. We selected most functions IGF2R had, and list some proteins which have the same functions with IGF2R. You can find most of the proteins on our site.
Function
Related Protein
Function glycoprotein binding
Related Protein B2M; FBXO6; VIM; LDLR; RAB14; SHB; Serpina1b; FBXO17; SERPINA1A; CNTN2
Function identical protein binding
Related Protein TRIP10; RCAN1; TRIM21; HOOK1; DAPK2; INS; BCL2; MDM2; PAK2; RBM10
Function insulin-like growth factor binding
Related Protein KAZALD1; HTRA4; IGF1RA; DEFB126; HTRA1B; CTGFA; Igfbpl1; CYR61L1; IGFBP3; HTRA3
Function insulin-like growth factor-activated receptor activity
Related Protein IGF2R; IGF1R
Function mannose binding
Related Protein BSG; MRC1; COLEC10; MBL2; CD209; MANBA; LMAN2; CLEC4M; CD209C; IGF2R
Function phosphoprotein binding
Related Protein MS4A2; SAG; PAFAH1B1; PKD2; PRKCSH; SNCA; CSNK1D; TBL2; LRP11; PLAT
Function protein binding
Related Protein NMUR2; MYL2; HADHB; KIF2C; SPRR2A; AMOTL2; LGALS9C; NUMA1; PENK; FNIP1
Function receptor activity
Related Protein CD244; FKBP3; NOTCH1B; PAQR9; GFRA4A; NOTCH4; DARC; KLRG1; GP6; ROBO4
Function transporter activity
Related Protein SLC6A18; KIF20A; FXYD2; XPO1; AQP8B; SLC5A12; SLCO1A5; RLBP1; ABCB8; GABRA5

Interacting Protein

IGF2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2R.
GGA1; GGA3; IGF2

IGF2R Related Articles

O'Doherty, AM; Magee, DA; et al. DNA methylation dynamics at imprinted genes during bovine pre-implantation embryo development. BMC DEVELOPMENTAL BIOLOGY 15:-(2015).
Moore, GE; Ishida, M; et al. The role and interaction of imprinted genes in human fetal growth. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 370:-(2015).