ikbkb
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  • Official Full Name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • Background
  • NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms
  • IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
Cat.#:IKBKB-501HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKB Protein, MYC/DDK-tagged
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Cat.#:IKBKB-125HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB protein, GST-tagged
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Cat.#:IKBKB-14132HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB, GST-tagged
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Cat.#:IKBKB-1720HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB protein, His & GST-tagged
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Cat.#:IKBKB-28877THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IKBKB
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Cat.#:IKBKB-53HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IKBKB protein, Flag-tagged, Biotinylated
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Cat.#:IKBKB-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human hIKKB-beta, His-tagged
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Cat.#:IKBKB-88HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKKB-beta, active
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Cat.#:IKBKB-89HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKB-beta
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Cat.#:Ikbkb-1721MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ikbkb protein, His & T7-tagged
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Cat.#:IKBKB-2225RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IKBKB Protein, His-tagged
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Cat.#:IKBKB-3048CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKBKB
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Cat.#:IKBKB-6658ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKB
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Cat.#:IKBKB-1027HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged
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Cat.#:IKBKB-2661HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB, GST-His
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Cat.#:IKBKB-760HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human IKBKB, His-S
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Cat.#:IKBKB-849HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IKBKB cell lysate
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Involved Pathway

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TAOK1; RAF1A; CACNG1A; CACNA1SB; MAP3K11; MAPK8A; DUSP3; PPM1A; RAP1A; MAPK11
Ras signaling pathway
PIK3R5; PLCE1; CALML5; KIT; Pdgfa&Pdgfb; FGF21; RGL2; FGF17; RAC3; RGL1
Chemokine signaling pathway
GM2506; GNG5; PTK2; CXCL1; CXCL8; LOC100033925; CCL13; ELMO1; PF4V1; GNG7
NF-kappa B signaling pathway
PLCG2; ZAP70; Ccl21c; BCL10; TNFAIP3; TRAF3; UBE2I; TAB2; MYD88; TRAF1
FoxO signaling pathway
IKBKB; TGFB1; MAPK13; MAP2K2A; PRMT1; SIRT1; BCL6A; KLF2A; SMAD2; SGK2
mTOR signaling pathway
AKT3A; PTEN; CAB39L; PDPK1; RPS6KA1; ULK3; RRAGD; HIF1AB; BRAF; RPS6KB1
PIK-Akt signaling pathway
TCL1; G6PC; TRP53; GH2; TP53; PRL; IFNB1; BCL2L1; TEK; GH1
Apoptosis
DCC; AIFM1; TRP53; STK24B; IRF4A; NTRK1; DSG1; SPNA2; GZMF; PIK3CD
Osteoclast differentiation
MAPK3; NFATC2; CSF1R; IFNGR1; PPP3CB; GRB2; IKBKB; PLCG2; PIK3R3; CAMK4
Toll-like receptor signaling pathway
Ifna15; MAPK9; MAPK12B; IFNB1; RAC1A; IL-8; MYD88; TLR9; TLR8; RIPK1L
NOD-like receptor signaling pathway
CARD9; RIPK2; MAPK12B; CASPA; MAPK13; MAPK11; CCL5; HSP90AA1.2; MAPK12; RELA
RIG-I-like receptor signaling pathway
TRADD; CASP10; IFNPHI3; IL12B; NT5C3; RIPK1; TRIM25; MAPK12; IFNA17; RNF207B
Cytosolic DNA-sensing pathway
IFNA10; AIM2; IFNA16; IKBKG; DDX58; IKBKB; IL1B; POLR2L; POLR3F; POLR2E
T cell receptor signaling pathway
NFKBIA; AKT2; PIK3CG; MAPK13; FOS; CD8B; GSK3B; SOS1; PIK3R2; MUC1
B cell receptor signaling pathway
NFKB1; PIK3R1; PIK3CD; PDK2B; CMTM3; CD19; NFATC3; INPPL1; HRAS; NRAS
TNF signaling pathway
RIPK1; MMP9; MAPK12; CREB3L3; CREB3L2; TAB2; TRADD; CREB3L1; MAP3K7; CASP7
Neurotrophin signaling pathway
PSEN2; CALML3; CAMK2D; NFKBIE; IRS1; MAP2K1; NTF3; SHC3; MAP3K3; MAP3K1
Insulin signaling pathway
BRAF; PRKACA; GRB2A; RPS6KB2; TSC2; CALM1A; FOXO1A; RAF1; PRKAG1; CALML5
Adipocytokine signaling pathway
AKT2L; MAPK9; ACSL4A; PRKAG2; POMC; RXRGA; PTPN11; PRKAB1; IRS2; ADIPOR1B
Type II diabetes mellitus
IRS4; IRS2; HK1; HK3; PIK3R3; PIK3CG; MAFA; SOCS3; PIK3CB; PIK3CD
Insulin resistance
TNFRSF1A; NOS3; NFKBIA; PPARAB; MAPK8A; PPP2R4; PYGL; PPP1R3DA; PTPRFB; PCK1
Non-alcoholic fatty liver disease (NAFLD)
INS; IL1B; MLXIPL; NDUFV1; AKT1; IRS1; NDUFB2; NDUFB6; NDUFA13; AKT2
Epithelial cell signaling in Helicobacter pylori infection
LYN; JAM2; ATP6V1B2; ATP6V1C2; ATP6V1G2; NFKB1; MAPK12; ATP6V0B; ATP6V0C; PAK1
Shigellosis
SRC; MAPK3; ELMO1; UBE2D2; ROCK2; PFN1; U2AF1L4; ACTG1; PFN3; BTRC
Chagas disease (American trypanosomiasis)
FADD; AKT1; Ccl12; PLCB1; IL-8; PPP2CA; TGFB2; GNAI1; C1QB; IFNGR2
Toxoplasmosis
Toxoplasma Gondii Microneme Protein MIC3; HLA-DMA; NFKBIA; LAMB4; CD40; LAMA5; HLA-DQA1; GNAI3; HLA-DRB3; H2-AA
Hepatitis C
Ifna15; IFNA4; MAPK3; CLDN23; TRAF3; PIK3R1; CLDN6; RIPK1; PIK3R2; NRAS
Hepatitis B
RAF1; PIK3R2; CCNA2; TLR2; HRAS; CREB3L1; IFNA8; STAT6; PIK3CA; IL-8
Influenza A
CASP9; IL1A; GSK3B; HSPA1B; OAS1; AKT2; DDX58; IL-8; NLRX1; MAP2K4
HTLV-I infection
ZFP36; RELA; RB1; HLA-DRB4; NFATC4; WNT8B; RELB; MYBL1; PRKACB; VCAM1
Herpes simplex infection
HLA-DRA; SRSF1; CDC34; CD74A; SRSF5; ARNTL1A; TNFSF14; TAP2; MHC2A; BLA
Epstein-Barr virus infection
POLR2E; LYN; POLR2F; POLR3G; Fcer2a; POLR2H; RB1; PIK3R2; IFNG; HSPB1
Pathways in cancer
TRAF4; TCEB2; IGF1R; AKT2; FZD8; AXIN2; PDGFRB; SPI1; PTGS2; MAPK8
MicroRNAs in cancer
GLS; NOTCH4; EZR; SOCS1; PTEN; ABCB1; MAPK7; HOXD10; Casp3; PLCG1
Pancreatic cancer
TGFA; PIK3R3; VEGFA; ARAF; SMAD4; RB1; STAT3; RAD51; AKT1; MAP2K1
Prostate cancer
TP53; SMARCD1; IKBKB; NDRG1; AKT1; PIK3CB; FOXO1; CREB5; FOXA1; ARID1A
Chronic myeloid leukemia
STAT5A; SMAD3; CTBP1; RB1; ABL1; PIK3R2; TGFBR2; HRAS; CBLC; CCND1
Acute myeloid leukemia
PML; TCF7; PIK3CD; CCNA1; IKBKG; CEBPA; RUNX1; SOS1; PIK3CG; SPI1
Small cell lung cancer
CASP9; AKT1; ITGB1; ITGA2; LAMA3; COL4A1; NFKBIA; RB1; BCL2; RXRB

Protein Function

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP2C1; MKI67; C9orf96; BMPR1AB; EPHB1; CERK; ERBB4A; ABCA1; TBCK; ACSL1
Function IkappaB kinase activity
Related Protein CHUK; IKBKE; IKBKB
Function protein binding
Related Protein CSNK1G2; WDR24; KRT40; GATA4; ACAA1; ANKFY1; SERBP1; CIAO1; CGGBP1; RAMP3
Function protein heterodimerization activity
Related Protein FLOT2; MCL1A; TLR6; TENM2; NEUROD2; POLA1; CHRNB4; TPD52; ADRA1B; HIST1H2AG
Function protein homodimerization activity
Related Protein SLC9A7; MGST1; MBL1; KIAA0947; FGFR1; NR6A1B; HEYL; PRPS2; FAP; MLL1
Function protein kinase activity
Related Protein PDK4; MAP3K12; MAP2K5; SCYL2; GM4922; RPS6KA3; LTK; GSG2; CDK13; ULK1A
Function protein kinase binding
Related Protein CASP9; FAM83B; CALM1; CENPJ; ILK; MAPK4; MAPK6; NCS1; BCAR1; PPP1R12A
Function protein serine/threonine kinase activity
Related Protein MAP3K14; DCKL1B; NLK1; STK33; TRPM6; CAMK1DB; CDK15; AKT3A; CSNK2A1; MAPK11
Function scaffold protein binding
Related Protein TREM2; NLGN1; MDM2; CRIPT; GRIN2A; DLG4; MAP2K2; CAV2; SHANK3; SRC

Interacting Protein

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
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