ikbkb
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  • Official Full Name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • Background
  • NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms
  • IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
Cat.#:IKBKB-501HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKB Protein, MYC/DDK-tagged
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Cat.#:IKBKB-125HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB protein, GST-tagged
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Cat.#:IKBKB-14132HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB, GST-tagged
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Cat.#:IKBKB-1720HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB protein, His & GST-tagged
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Cat.#:IKBKB-28877THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IKBKB
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Cat.#:IKBKB-53HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IKBKB protein, Flag-tagged, Biotinylated
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Cat.#:IKBKB-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human hIKKB-beta, His-tagged
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Cat.#:IKBKB-88HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKKB-beta, active
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Cat.#:IKBKB-89HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKB-beta
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Cat.#:Ikbkb-1721MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ikbkb protein, His & T7-tagged
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Cat.#:IKBKB-2225RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IKBKB Protein, His-tagged
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Cat.#:IKBKB-3048CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKBKB
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Cat.#:IKBKB-6658ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKB
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Cat.#:IKBKB-1027HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged
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Cat.#:IKBKB-2661HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB, GST-His
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Cat.#:IKBKB-760HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human IKBKB, His-S
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Cat.#:IKBKB-849HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IKBKB cell lysate
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Involved Pathway

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GADD45AB; MAPK8B; PPM1A; IL1A; RAF1B; GADD45BB; RAC2; TRP53; PAK2A; FGF2
Ras signaling pathway
ANGPT4; SHC3; RASA4; REL; IKBKB; FGF14; PIK3CG; INS; FGF18; RASSF1
Chemokine signaling pathway
CDC42; DOCK2; PPBP; CXCR2; XCL1; MAPK1; CXCR6; FGR; CXCL8; ELMO1
NF-kappa B signaling pathway
PLCG2; IL1R1; IRAK1; LTB; ICAM1; ZAP70; VCAM1; BCL2A1A; TRADD; LAT
FoxO signaling pathway
KLF2; PIK3R1; PLK1; PIK3R2; SGK2; SMAD3A; RAF1B; KLF2A; INS1; STK11
mTOR signaling pathway
IKBKB; PIK3CA; PRKAA2; EIF4E2RS1; RPTOR; PRKCB; RPS6KA3B; DDIT4; PIK3R1; IRS1
PIK-Akt signaling pathway
TP53; FGF3; PDGFRA; PKN1; GHR; IL3RA; IFNA14; NFKB1; PRKAA2; PRLR
Apoptosis
PIK3R3A; DSG2; PPP3CB; CAPN1A; CRADD; IL3RA; IL1RAP; AKT3A; CASP4; AKT1
Osteoclast differentiation
NFATC1; RELB; SIRP-BETA; NOX1; TGFB2; FHL2; MAP2K7; IFNGR1; NCF4; PIK3R2
Toll-like receptor signaling pathway
RAC1A; RIPK1; IL-8; MAPK12A; TLR5B; NFKBIA; IL12A; IL6; IRAK4; MYD88
NOD-like receptor signaling pathway
NAIP6; HSP90AB1; CXCL2; NFKBIAB; MAPK14A; ERBB2IP; CARD18; CCL2; IKBKB; IL18
RIG-I-like receptor signaling pathway
ATG5; NFKBIB; IFIH1; MAP3K1; RNF125; IFNA2; IFNA13; IFNA4; RIPK1L; IKBKG
Cytosolic DNA-sensing pathway
ZBP1; ADAR; POLR3C; IL18; IFN-a; IKBKG; NFKBIA; IFNA6; IFNA14; MB21D1
T cell receptor signaling pathway
KRAS; CBL; SOS1; MAP2K2; NFKB1; PPP3CB; GRAPA; SHB; MAP3K7; CD4
B cell receptor signaling pathway
IFITM1; PIK3R3; ITK; PPP3CC; PIK3R1; PIK3CB; PPP3CB; MAP2K1; CSK; TTC6
TNF signaling pathway
MAP2K4; DNM1L; MAGI2; MAP2K7; RELA; TRAF1; TNF; MAPK1; CXCL3; MAPK12
Neurotrophin signaling pathway
NTRK3; MAPK7; CALM2; SHC2; ZFP110; ARHGDIG; ARHGDIB; Fasl; PIK3R5; CALM1
Insulin signaling pathway
PIK3CA; FLOT2A; BADB; PYGL; CALM3A; PTPRFB; CALM1A; PRKACA; PRKAR2AB; ARAF
Adipocytokine signaling pathway
NFKB1; PRKAB1A; ACSL3B; SOCS3; ADIPOQ; ACSL4B; TRADD; AKT2L; PRKAG2; MAPK8B
Type II diabetes mellitus
PIK3CG; PIK3CD; ADIPOQ; PKM2; PKLR; IKBKB; HK3; SOCS2; PIK3R5; TNF
Insulin resistance
PCK2; CREB3L2; PRKCBB; SLC27A3; PPP1CA; CD36; CREB3L1; RPS6KA6; CREB1A; NFKBIA
Non-alcoholic fatty liver disease (NAFLD)
NDUFS7; GSK3B; NDUFB5; UQCR10; UQCRC2; NDUFA3; NDUFB11; NDUFB9; NDUFV1; SDHA
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1A; MAPK10; ATP6V1C2; NOD1; ATP6V0A1; MAP2K4; ATP6V1G3; MAPK11; MAP3K14; CXCR1
Shigellosis
NFKBIB; BTRC; MAPK8; PFN3; ROCK1; MAPK10; U2AF1; ATG5; CD44; U2AF1L4
Chagas disease (American trypanosomiasis)
CCL3L3; C1QB; IKBKG; MAP2K4; SMAD3; PLCB2; TLR6; PIK3CD; IL12A; TGFB3
Toxoplasmosis
AKT2; STAT1; TNF; IKBKB; TYK2; GNAI2; TGFB2; IL10RA; LY96; TGFB1
Hepatitis C
PPP2CB; PIK3CB; CLDN20; TRADD; CLDN16; HRAS; PIAS1; IFNA14; MAPK8; PPP2R2B
Hepatitis B
TICAM2; TLR3; SMAD4; IFNA10; Casp3; KRAS; DDB2; IFNA8; IFNA13; STAT3
Influenza A
IFN-a; HLA-DRB1; TNFRSF10D; IKBKE; TNFRSF10C; DDX58; PIK3CB; IFNA5; PABPN1; MAVS
HTLV-I infection
CD3D; RAN; MYBL2; ETS2; ATF4; SLC25A6; RRAS2; FOS; IKBKB; WNT9B
Herpes simplex infection
TAF4B; IFNA3; HLA-DQB1; NFKB1; NXF1; TAB2; C1QBP; IRF7; FAS; PPP1CAA
Epstein-Barr virus infection
TBK1; HSPA1A; HLA-DRB5; SKP2; CD38; PSMC3; POLR2D; POLR2C; MAPK8; POLR3GL
Pathways in cancer
LPAR4; LAMB3; ARHGEF12; ROCK1; LAMA3; LAMA4; TRAF6; WNT8A; BIRC5; HRAS
MicroRNAs in cancer
CDC25C; CDC25B; RECK; ABCB1A; GLS2; IRS1; MDM2; CCNE1; STAT3; MMP16
Pancreatic cancer
AKT1; RELA; SMAD2; BCL2L1; PIK3R1; PIK3CG; MAPK1; TRP53; PIK3R2; ARAF
Prostate cancer
INS1; CCND1; ARAF; MAP2K2; IKBKB; PDGFD; SMARCA4; MAPK1; Ar; FGFR1
Chronic myeloid leukemia
KRAS; STAT5B; PTPN11; CBLC; NFKBIA; PIK3R1; SHC1; RB1; PIK3CD; STAT5A
Acute myeloid leukemia
MYC; AKT2; GRB2; HRAS; SFPI1; BAD; FLT3; PML; CHUK; PIK3R3
Small cell lung cancer
PIK3CA; RARB; ITGAV; RXRA; BIRC7; AKT2; PTK2; BCL2; RELA; MAX

Protein Function

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CHD1L; RAF1A; PTK7A; DARS2; MASTL; BMPR1AB; CHD4A; NLRP5; ABCG2D; DCAMKL2
Function IkappaB kinase activity
Related Protein IKBKE; IKBKB; CHUK
Function protein binding
Related Protein PLN; RPP38; RFX1; GNAI1; ZNF34; PALB2; SF3B3; DTX1; KRT14; FBXO17
Function protein heterodimerization activity
Related Protein H3F3C; PANX2; TAF6; HIST1H2AI; DDX1; ANO9A; HIST1H2BN; CABYR; NFYC; SNX2
Function protein homodimerization activity
Related Protein HPGD; GIPC1; MFF; ECE1; CREB3; MAOB; AP1S2; LILRB1; MITD1; GOT2
Function protein kinase activity
Related Protein ERBB3A; BMPR1BB; GUCY2C; TBCK; MAP4K6; MOK; PRKG1A; RPS6KA3A; STK25B; TGFBR1A
Function protein kinase binding
Related Protein CCNT2A; MAPK4; JAK2; ADRA2A; DLG1L; PAK2; CAV2; DLG1; PRKAB1; CD3E
Function protein serine/threonine kinase activity
Related Protein LIMK1; STK17B; DAPK3; STK39; TTK; ADCK1; PKN1B; MAP2K2; CSNK2A2; PRKCBB
Function scaffold protein binding
Related Protein CHRNA7; KRT18; DLG4; PDE4D; CASP8; PANX1; CACNA1G; KCNQ1; HOMER1; CRIPT

Interacting Protein

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
IKBKG