ikbkb
Share
  • Official Full Name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • Background
  • NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms
  • IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
Cat.#:IKBKB-501HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKB Protein, MYC/DDK-tagged
+Inquiry
Cat.#:IKBKB-125HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB protein, GST-tagged
+Inquiry
Cat.#:IKBKB-14132HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB, GST-tagged
+Inquiry
Cat.#:IKBKB-1720HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB protein, His & GST-tagged
+Inquiry
Cat.#:IKBKB-28877THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IKBKB
+Inquiry
Cat.#:IKBKB-53HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IKBKB protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:IKBKB-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human hIKKB-beta, His-tagged
+Inquiry
Cat.#:IKBKB-88HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKKB-beta, active
+Inquiry
Cat.#:IKBKB-89HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKB-beta
+Inquiry
Cat.#:Ikbkb-1721MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ikbkb protein, His & T7-tagged
+Inquiry
Cat.#:IKBKB-2225RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IKBKB Protein, His-tagged
+Inquiry
Cat.#:IKBKB-3048CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKBKB
+Inquiry
Cat.#:IKBKB-6658ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKB
+Inquiry
Cat.#:IKBKB-1027HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged
+Inquiry
Cat.#:IKBKB-2661HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB, GST-His
+Inquiry
Cat.#:IKBKB-760HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human IKBKB, His-S
+Inquiry
Cat.#:IKBKB-849HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IKBKB cell lysate
+Inquiry

Involved Pathway

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK14A; MAP3K1; SRFA; MEF2CA; FGF22; MAP3K11; ELK1; FGF14; RPS6KAL; MECOM
Ras signaling pathway
PLA2G4D; PRKCA; Kitl; PLA2G6; TBK1; FGF4; FGF21; SOS1; SHC2; KITLG
Chemokine signaling pathway
AKT2; CCL26; CCL20; CXCR6; CCL25; AMCF-II; RAP1B; GNG10; CCL22; GM1987
NF-kappa B signaling pathway
RIPK1; PLAU; Bcl2a1b; IL1R1; TNFSF14; LCK; RELA; ICAM1; IKBKB; IRAK4
FoxO signaling pathway
RAG1; HRASA; AKT2L; AKT2; EGFRA; SMAD2; SGK2B; MAPK14B; MAPK8; PIK3R3
mTOR signaling pathway
PIK3R3; TSC2; RPS6KB1; PRR5; PDPK1B; RPS6; PRKAA2; PDPK1; PIK3CA; PIK3R5
PIK-Akt signaling pathway
PRL; FGF10; G6PC; PTK2; KITLG; GSK3B; COL27A1; BRCA1; Fgf15; ITGA2B
Apoptosis
CYCS; PPP3R1B; FASLG; STK24A; CASP8L1; HIST1H1A; PRKAR1B; BCL2A; CASP2; PLEC
Osteoclast differentiation
IL1R1; TGFBR2; PPP3CB; PIK3CA; PIK3CG; FOSL1; RELA; SOCS3; MAP2K6; GAB2
Toll-like receptor signaling pathway
IFNA13; TOLLIP; IFNB; MAP2K4B; MAPK14B; TBK1; AKT3A; TLR5B; MAPK8; PIK3CA
NOD-like receptor signaling pathway
CASP8; IKBKG; MAP3K7IP3; NFKBIA; CASP5; NAIP6; IL8L2; MAPK1; MAPK8; PSTPIP1A
RIG-I-like receptor signaling pathway
FADD; TRAF3; TRAF6; SIKE1; IL8L1; ISG15; TBK1; IFNA17; IL12A; IFNB
Cytosolic DNA-sensing pathway
PYCARD; RIPK3; MAVS; IL18; POLR2E; ZBP1; POLR3GL; IFNA3; IKBKB; POLR2H
T cell receptor signaling pathway
CD247; NFKBIB; PAK6; OXSR1A; CD8B1; MAPK12; PIK3R1; NFATC1; AKT1; PAK7
B cell receptor signaling pathway
DAPP1; PDK2; CDK4; NEDD9; PPP3CA; ITPR2; PPP3CC; VAV2; HRAS; BCL10
TNF signaling pathway
Casp3; FAS; CCL5; MAPK13; MAP3K5; PIK3CG; TRAF2; ATF4; RPS6KA5; CASP10
Neurotrophin signaling pathway
CAMK2B; MAPK8; PTPN11; BDNF; RAP1B; NGFRAP1; CAMK2A; MATK; BRAF; IRAK2
Insulin signaling pathway
NRAS; FASN; RPS6KB2; RAF1B; G6PCA.1; INPPL1; MKNK2; PHKG1; PPP1R3C; SLC2A4
Adipocytokine signaling pathway
CAMKK1; ACSL5; ACSL3A; ACSL1; MAPK9; TNFRSF1A; PTPN11B; ACSL3; NFKBIAA; ACSL4
Type II diabetes mellitus
MAPK10; PIK3R3; PIK3CD; SOCS3; INS; PKM2; PIK3CG; PIK3CB; IRS1; PDX1
Insulin resistance
TNF; NFKBIA; PRKAB1A; CRTC2; TRIB3; PRKAG3B; PIK3R3A; IRS2; PPP1R3CB; PRKCBB
Non-alcoholic fatty liver disease (NAFLD)
NDUFA4L2; NFKB1; NDUFS3; Casp3; NDUFC1; IKBKB; MAPK9; NDUFA2; NDUFA5; ITCH
Epithelial cell signaling in Helicobacter pylori infection
JAM2; ATP6V1E2; PLCG2; LYN; MET; ADAM17; ATP6V1B1; RELA; F11R; IKBKG
Shigellosis
ROCK1; HCLS1; MAPK8; PFN1; ELMO1; ELMO2; MAPK13; ATG5; MAD2L2; MAPK9
Chagas disease (American trypanosomiasis)
MAPK3; PPP2CA; IFNG; IRAK1; GNAI3; IL12B; CXCL8; PPP2R1B; PIK3R1; GNAL
Toxoplasmosis
NFKBIA; LAMA3; PPIF; PIK3R3; MAPK3; IL12A; MAP2K6; HLA-DQB1; TGFB3; IRGM1
Hepatitis C
IKBKE; IFNA10; IL-8; PPP2R1B; EIF3E; IRF1; RNASEL; IKBKG; IFNA13; TBK1
Hepatitis B
MAPK10; CCNE2; PIK3R2; Fasl; NFATC3; CASP9; TLR3; IFNA2; OSTN; IKBKE
Influenza A
CYCS; BMA2; MAP2K6; FAS; EIF2AK2; HLA-DRB5; ADAR; PIK3R1; OAS1; RAF1
HTLV-I infection
TP53; XBP1; SPI1; CD3E; CD3D; RELB; IL2RA; ANAPC7; FZD3; TGFB3; HLA-DRB3
Herpes simplex infection
SRSF6; EIF2AK2; MHC1UEA; CDC34A; TAF5L; CDK1; Hc; CCL2; TAF6L; CASP8
Epstein-Barr virus infection
HLA-DPB1; MAP2K4; POLR3B; TBPL1; MAPK10; RIPK1; HLA-G; SPI1; POLR2I; TRAF6
Pathways in cancer
FGF21; NFKB2; FZD5; CBL; PIK3CA; GNAI2; FGF8; GNG12; ITGA6; LAMC1
MicroRNAs in cancer
ZFPM2; RDX; SOCS1; HRAS; ZEB2; STMN1; ITGB3; EZH2; NFKB1; CDC25B
Pancreatic cancer
BCL2L1; SMAD3; RAC1; RAF1; RAD51; AKT1; IKBKG; RALBP1; KRAS; PLD1
Prostate cancer
PIK3R2; PTEN; BRAF; MAP2K1; PIK3CA; AKT2; CREB5; NFKBIA; CCNE2; NKX3
Chronic myeloid leukemia
TGFB3; MAPK3; RUNX1; CBL; MECOM; STAT5A; TGFB1; ARAF; KRAS; NFKBIA
Acute myeloid leukemia
MAP2K1; BAD; ARAF; CEBPA; RUNX1; PML; PIK3R1; ZBTB16; PIK3R3; PIM1
Small cell lung cancer
BCL2; ITGA3; PIK3R3; IKBKG; CYCS; LAMB1; CKS2; ITGA2B; TRAF2; ITGB1

Protein Function

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SBK3; AARSD1; SRPK1A; BLM; ASNA1; KATNAL2; TARS2; DQX1; MAT1A; MAP2K2
Function IkappaB kinase activity
Related Protein IKBKB; IKBKE; CHUK
Function protein binding
Related Protein PKD1; PROM1; RAB39A; RFC4; CDKAL1; MOBKL1A; GSDMA2; CDC7; MYLIPA; PHLDA1
Function protein heterodimerization activity
Related Protein PANX2; NPAS4; HEXA; PEF1; TOP2B; CD3D; TAF4B; HIST1H4H; PIK3R1; TAF8
Function protein homodimerization activity
Related Protein CAMK2A; SNX2; CHMP4C; TLR13; MIXL1; RIPK2; TERT; ADD1; ERN1; CRYM
Function protein kinase activity
Related Protein MAP2K1; POMK; ERBB4A; PRKCA; MAP4K3; DAPK1; PRKCG; MAPKAPK2; IGF1RB; CSNK1E
Function protein kinase binding
Related Protein APC; KIF14; PPP1R12C; SPDYB; RNF138; NEFH; PRKAG3; ATF2; SOCS1; BAD
Function protein serine/threonine kinase activity
Related Protein MAPK11; DYRK2; STK33; STK16; MAPK14A; ACVR1BA; ATM; MAP2K2; STK38A; VRK3
Function scaffold protein binding
Related Protein P2RY1; CRIPT; NOS3; MAP2K2; PARK7; CIT; LRP4; NCK2; NLGN4Y; PANX1

Interacting Protein

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
IKBKG