ikbkb
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  • Official Full Name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • Background
  • NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms
  • IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
Cat.#:IKBKB-501HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKB Protein, MYC/DDK-tagged
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Cat.#:IKBKB-125HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB protein, GST-tagged
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Cat.#:IKBKB-14132HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB, GST-tagged
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Cat.#:IKBKB-1720HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKB protein, His & GST-tagged
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Cat.#:IKBKB-28877THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IKBKB
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Cat.#:IKBKB-53HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IKBKB protein, Flag-tagged, Biotinylated
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Cat.#:IKBKB-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human hIKKB-beta, His-tagged
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Cat.#:IKBKB-88HTag:GST|His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKKB-beta, active
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Cat.#:IKBKB-89HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKB-beta
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Cat.#:Ikbkb-1721MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ikbkb protein, His & T7-tagged
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Cat.#:IKBKB-2225RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IKBKB Protein, His-tagged
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Cat.#:IKBKB-3048CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKBKB
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Cat.#:IKBKB-6658ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKB
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Cat.#:IKBKB-1027HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged
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Cat.#:IKBKB-2661HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IKBKB, GST-His
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Cat.#:IKBKB-760HTag:His
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human IKBKB, His-S
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Cat.#:IKBKB-849HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IKBKB cell lysate
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Involved Pathway

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG1A; KRAS; PPP3CCA; PRKACB; MAPK4; LAMTOR3; MAPK8B; Pdgfa&Pdgfb; NTRK2; NFKB1
Ras signaling pathway
ABL2; PLA1A; Pdgfa&Pdgfb; FGF4; PRKACA; CALM4; LAT; NF1; CSF1; FGF3
Chemokine signaling pathway
GNG7; CXCR3; PRKACB; CCR6; HCK; Ccl27a; SHC1; GSK3B; CCL26; GNG3
NF-kappa B signaling pathway
BCL2A1A; ERC1; LYN; TRIM25; TNFRSF13C; TNFRSF11A; RELB; TNFAIP3; DDX58; BIRC2
FoxO signaling pathway
HOMER3; RAF1B; MAPK12B; CAT; PIK3CB; MAPK8B; TGFB1; G6PC2; PRKAG3; CDKN1BB
mTOR signaling pathway
PIK3R5; MAPK1; INS2; STRADA; RICTOR; PRKCBB; AKT3A; MTOR; PTEN; BRAF
PIK-Akt signaling pathway
FGF11; PTK2; CREB3L2; GSK3B; FGF22; TRP53; FN1; FOXO3; KIT; FIGF
Apoptosis
STK24; NFKB1; IRF4A; STK26; VIML; BOKA; BAX; PIK3R1; PPP3CCA; CASP8
Osteoclast differentiation
SOCS1; SIRPG; PIK3CG; PPP3R2; NOX1; LILRB1; SFPI1; FCGR3; NFATC1; RAC1
Toll-like receptor signaling pathway
TLR1LB; CD40; IL6; TLR4BB; TOLLIP; TRAF3; MAPK13; MAP2K2A; NFKBIAB; TLR2
NOD-like receptor signaling pathway
IL8L1; RELA; TNF; CXCL1; HSP90B1; MAPK13; IL8L2; CCL2; MAPK11; SGUT1
RIG-I-like receptor signaling pathway
ISG15; TBKBP1; RNF125; IFNB; TANK; IFNA3; OTUD5A; IRF3; IL8L2; RIPK1L
Cytosolic DNA-sensing pathway
PYCARD; CCL4; IFNA4; IFNA17; RIPK1; POLR2EB; IFI202B; POLR2F; IFNA14; POLR3H
T cell receptor signaling pathway
NCK1; FYN; PTPRC; GSK3B; EVLB; MAPK13; NFKB1; CABIN1; Il2; PPP3CC
B cell receptor signaling pathway
NFATC1; PTPN18; Cd79a, Cd79b; ITK; BCL10; PLEKHA1; IKBKB; PIK3CA; LILRB3; PIK3R3
TNF signaling pathway
IKBKG; CASP7; PTGS2; MAP2K6; CFLAR; CCL2; TNFRSF1B; MAPK10; PIK3CD; TNFRSF1A
Neurotrophin signaling pathway
BRAF; SH2B3; PIK3R5; TRAF6; NGFRAP1; BAX; ABL1; RPS6KA2; BDNF; KIDINS220
Insulin signaling pathway
PRKAR2A; PRKACG; PRKAG2; PRKACAB; RAF1B; AKT3A; HKDC1; ACACB; RAPGEF1; PYGL
Adipocytokine signaling pathway
MAPK9; ACSL1; TNFRSF1A; ACSL5; PCK1; RXRGB; STAT3; STK11; PPARA; PRKAA1
Type II diabetes mellitus
MAFA; MAPK9; HK2; HK3; PRKCD; PIK3CD; MTOR; PIK3R2; TNF; MAPK8
Insulin resistance
CREB3L1; FOXO1; PDPK1B; PRKCBA; GFPT1; MAPK8A; PPP1R3C; PCK1; SLC2A1; PIK3R2
Non-alcoholic fatty liver disease (NAFLD)
UQCR11; NDUFA13; IL6; NDUFV3; INSR; NDUFB2; MLXIPL; PRKAG1; NDUFB5; UQCRC2
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1E1; ATP6V1F; ATP6V1A; ATP6V1G2; PTPN11; MAP2K4; JAM3; ATP6V1E2; IL-8; CCL5
Shigellosis
IKBKG; CDC42; ARPC5L; RIPK2; ROCK2; MAPK9; IL-8; ELMO1; PFN4; U2AF1
Chagas disease (American trypanosomiasis)
AKT2; PPP2CA; ACE; LOC100033925; PIK3CB; GNAO1; IL-8; IL10; NFKB1; FADD
Toxoplasmosis
PIK3R1; MAPK12; HLA-DRA; MAPK8; PIK3CD; ALOX5; HLA-DRB1; SOCS1; MYD88; H2-AB1
Hepatitis C
CLDN17; Ifna15; IFNA7; CLDN9; STAT3; CLDN8; IKBKB; CLDN10; CD81; OAS1B
Hepatitis B
NFATC3; APAF1; PIK3CD; MAPK8; IFIH1; TGFB3; TGFB2; MMP9; IFNA5; MAPK10
Influenza A
PML; IFNA12; IFNA3; SOCS3; HSPA2; IFN-a; TLR7; Fasl; TNFRSF10D; NXF2
HTLV-I infection
PTTG1; AKT2; WNT2B; MAP3K1; HLA-DQA2; FZD7; RRAS2; TRP53INP1; NFATC2; POLE2
Herpes simplex infection
OAS2; IFNA6; SRSF4; IRF9; HLA-C; PER2; IFIT1; SRSF6; EIF2AK3; MAVS
Epstein-Barr virus infection
PLCG2; POLR2D; HLA-C; TAB2; POLR1C; IL10RA; HLA-DQB1; CD40; PIK3R2; TBPL2
Pathways in cancer
GNG11; PTGS2; RARB; RXRB; BDKRB2; STK4; KIT; LPAR6; LPAR4; CDH1
MicroRNAs in cancer
HMOX1; SHC1; TGFB2; SLC7A1; ZEB1; STAT3; MAPK7; CCNE1; ST14; MAP2K1
Pancreatic cancer
IKBKB; TGFA; TGFB1; RALGDS; PIK3CA; SMAD3; PIK3CG; SMAD4; BAD; ARHGEF6
Prostate cancer
CPN1; CREB3L1; PIK3CG; GSK3B; PIK3R1; HRAS; INSRR; CCNE1; EP300; NFKBIA
Chronic myeloid leukemia
PIK3R3; SMAD4; SHC1; CTBP2; HDAC1; ARAF; RELA; PIK3R2; MAP2K2; CRKL
Acute myeloid leukemia
FLT3; CHUK; MYC; PIK3CD; PIK3CB; NFKB1; MAP2K2; BAD; NRAS; ZBTB16
Small cell lung cancer
NFKBIA; APAF1; TRAF1; TP53; PIAS2; LAMC1; TRAF5; FHIT; LAMA3; LAMB1

Protein Function

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2F; ATAD2; DDX59; ERN2; PFKFB2; ABCA8; CLCN4-2; SMARCA2; HSP90AA1; EPHA2A
Function IkappaB kinase activity
Related Protein IKBKE; IKBKB; CHUK
Function protein binding
Related Protein ZNF664-FAM101A; ADAP2; ZNRF1; PRKACB; HTR3C; CCDC25; PDCD6; CDC42EP2; TNFAIP8L2; PRMT3
Function protein heterodimerization activity
Related Protein HEXA; NFYBA; UGT1A4; HIST1H4E; Fzd4; IKZF4; SOX14; HIST4H4; CEBPG; NAE1
Function protein homodimerization activity
Related Protein RASGRP1; CHMP1A; KLHL7; UPK1A; XDH; TNNC1; NRBP1; DARS2; CTBP2; TARBP2
Function protein kinase activity
Related Protein HIPK3A; ACVR1L; PLK1; PHKG1B; IGF1RA; LIMK1; MAP4K1; MAP4K3; PRKCBA; BMPR1BB
Function protein kinase binding
Related Protein TBL2; WAS; CCND2; TPRKB; MVP; GRIN2A; DVL1; HDAC7; CAMK2N1; MAML1
Function protein serine/threonine kinase activity
Related Protein DAPK2; SRPK2; MAPK13; STK25; NEK12; RIPK1; CASK; PIM1; STK17B; STK35L
Function scaffold protein binding
Related Protein KRT8; HOMER1; LRP4; KCNQ1; NLGN4X; GRIN2A; PARK7; SRC; SHANK1; KCNA5

Interacting Protein

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
IKBKG