il10ra
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  • Official Full Name
  • interleukin 10 receptor, alpha
  • Background
  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms
  • IL10RA; interleukin 10 receptor, alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain;
Cat.#:IL10RA-001HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IL10RA Protein
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Cat.#:IL10RA-002HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL10RA Protein
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Cat.#:IL10RA-1116HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL10RA Protein (Met1-Asn235), His-tagged
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Cat.#:IL10RA-988RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus IL10RA Protein (Thr9-Asn245), His-tagged
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Cat.#:IL10RA-14141HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL10RA, GST-tagged
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Cat.#:IL10RA-211HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL10RA, MIgG2a Fc-tagged
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Cat.#:IL10RA-212HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL10RA, HIgG1 Fc-tagged
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Cat.#:IL10RA-236HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL10RA protein
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Cat.#:IL10RA-29631THTag:
Source (Host):Species:Human
Product nameRecombinant Human IL10RA
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Cat.#:IL10RA-54HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL10RA, His-tagged
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Cat.#:IL10RA-9302HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL10RA protein, MYC/DDK-tagged
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Cat.#:IL10RA-9390HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL10RA protein, His-tagged
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Cat.#:Il10ra-1726MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il10ra protein, His & GST-tagged
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Cat.#:IL10RA-8837CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL10RA, Fc tagged
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Cat.#:IL10RA-3393CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL10RA
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Cat.#:IL10RA-4812ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL10RA
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Cat.#:IL10RA-1648HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Interleukin 10 Receptor, Alpha
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Cat.#:IL10RA-492HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 10 Receptor, Alpha, Fc Chimera
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Cat.#:IL10RA-1185CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL10RA cell lysate
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Involved Pathway

IL10RA involved in several pathways and played different roles in them. We selected most pathways IL10RA participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL1; CCL27B; CCL21; IFNA10; CCL27; CXCL13; IL11; BMPR1AB; Ccl12; IL22RA2
Epstein-Barr virus infection
IKBKB; CD44; POLR1C; TAB2; PSMD11; POLR2J2; CDK1; IKBKG; ITGAL; HSPA2
Jak-STAT signaling pathway
STAT1A; CNTF; GM-CSF; CSF3; IL21; IL21R; IFNGR2; PRLR; CRFB2; PIK3CD
Toxoplasmosis
IRAK4; MAP2K6; HLA-DMB; CASP9; CASP8; MAPK13; TNFRSF1A; IKBKB; IFNGR1; ITGA6
Tuberculosis
CALML5; TLR4; MAPK8; RELA; AKT1; ATP6V0A1; CALML3; TRADD; TNF; IFNA6

Protein Function

IL10RA has several biochemical functions, for example, interleukin-10 binding, interleukin-10 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RA itself. We selected most functions IL10RA had, and list some proteins which have the same functions with IL10RA. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-10 binding
Related Protein IL10RA
Function interleukin-10 receptor activity
Related Protein IL10RA
Function protein binding
Related Protein EDEM1; IKZF2; BMI1; SEPT5; GOLGA2; ULK2; VASN; CCDC36; DDB2; CARHSP1
Function receptor activity
Related Protein PAQR4; GFRA1A; TIGIT; TACSTD2; MED16; NOTCH1B; LRRN2; RTN4RL1; ITGB3B; ATP6AP2
Function signal transducer activity
Related Protein FAS; AIP; TAAR12I; AVP; TACR1A; PLCB1; PTGER2B; OLFR186; GRM2A; PLCH1

Interacting Protein

IL10RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RA.
NS; il10h_ebvb9; UL111A; IL10; q6f051_bacan; dnaE; ilvC2

IL10RA Related Articles

Matesanz-Isabel, J; Sintes, J; et al. New B-cell CD molecules. IMMUNOLOGY LETTERS 134:104-112(2011).
Hennig, BJ; Fielding, K; et al. Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection. PLOS ONE 3:-(2008).

IL10RA Related Gene Family

IL