|Official Full Name||interleukin 10 receptor, alpha|
|Background||The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]|
|Synonyms||IL10RA; interleukin 10 receptor, alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IL10RA involved in several pathways and played different roles in them. We selected most pathways IL10RA participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||CXCL5; PRLR; IL18; TNFRSF13B; IL2RG; CCL1; IL12RB1; IFNE; CXCR4A; IFNL3|
|Epstein-Barr virus infection||EIF2AK3; PIK3CB; CSNK2A2; HLA-DPB1; POLR2D; RELA; PRKACB; PSMC5; SYK; TAB2|
|Jak-STAT signaling pathway||BCL2L1; AOX2P; IL22RA2; PIAS2; IFNA1; CRFB4; MYCB; IFNW1; OSM; IFNA2|
|Toxoplasmosis||XIAP; PIK3R5; CYCS; HLA-DOA; NFKB1; CD40; IL12A; TRAF6; HSPA1L; HLA-DRB3|
|Tuberculosis||APAF1; PPP3CB; IFNA16; TGFB3; LBP; NFYA; RAF1; HLA-DPB1; CD209A; IFNGR1|
IL10RA has several biochemical functions, for example, interleukin-10 binding, interleukin-10 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RA itself. We selected most functions IL10RA had, and list some proteins which have the same functions with IL10RA. You can find most of the proteins on our site.
|interleukin-10 receptor activity||IL10RA|
|protein binding||MAPRE2; CNIH2; INSIG1; RBM11; ADAM22; EIF2B4; PCGF1; MTERFD2; PDE2A; DZIP1|
|receptor activity||GABRA5; CSF2RB; GUCY1B3; LILRB3; PVRL1B; GRIA3A; VMN1R41; CCR6; PVR; GRIN1B|
|signal transducer activity||GPR25; OLFR18; VMN1R46; PPP5C; CREBBP; MIER1; V2RH32; MRGPRB8; TAS2R140; PLCB2|
IL10RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RA.
NS; il10h_ebvb9; UL111A; IL10; q6f051_bacan; dnaE; ilvC2