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IL29

  • Official Full Name

    interleukin 29 (interferon, lambda 1)

  • Overview

    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
  • Synonyms

    IL29; interleukin 29 (interferon, lambda 1); interleukin 29; interleukin-29; IFNL1; IL 29; IFN-lambda-1; cytokine Zcyto21; interferon lambda-1; interferon-lambda-1; interferon, lambda 1; IL-29;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Human
  • Pig
  • CHO
  • E.coli
  • HEK293
  • Human cells
  • Mammalian cells
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL29-003H Active Recombinant Human IL29, HIgG1 Fc-tagged CHO Fc
Human IL29-001H Active Recombinant Human IL29, MIgG2a Fc-tagged CHO Fc
Human IL29-002H Active Recombinant Human IL29, HIgG1 Fc-tagged, mutant CHO Fc
Human IL29-602H Recombinant Human Interleukin 29 (interferon, lambda 1) HEK293 N/A
Human IL29-381H Recombinant Human IL29 protein, His-tagged HEK293 His Met1-Thr200
Human IL29-100H Recombinant Human IL29 protein E.coli N/A 181
Human IL29-14194H Recombinant Human IL29, His-tagged E.coli His 24-200a.a.
Human IL29-222H Recombinant Human Interleukin 29 (Interferon, Lambda 1), His-tagged Mammalian cells His
Human IL29-5228HCL Recombinant Human IL29 293 Cell Lysate HEK293 N/A
Human IL29-5200H Active Recombinant Human IL29 Protein E.coli N/A
Human IL29-131H Active Recombinant Human IL29 Protein (Pro23-Thr200), C-His tagged, Animal-free, Carrier-free E.coli C-His Pro23-Thr200
Human IL29-3152H-B Recombinant Human IL29 Protein Pre-coupled Magnetic Beads HEK293
Human IL29-37H Interleukin-29 (Interferon Lamda 1) Reference standard N/A
Human IL29-2309H Recombinant Human IL29 Protein, His-tagged E.coli N-His Gly20-Thr200
Human IL29-4621H Recombinant Human IL29 protein, His-SUMO-tagged E.coli His-SUMO 21-200aa
Human IL29-34H Active Recombinant Human IL29 Protein, Animal Free Human cells
Human IL29-3152H Recombinant Human IL29 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL29-513H Recombinant Human IL29 Protein 200
Pig IL29-1034P Recombinant Pig IL29 Protein, His-tagged E.coli N-His Gly20-Ile191
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL29 Related Articles
  • IL29 Related Research Area

IL29 involved in several pathways and played different roles in them. We selected most pathways IL29 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL29 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFN-a;CXCL12;Il4ra;CSF2RA;CSF1;IFNG1-2;IFNA5;KITLGB;LIFRA
Jak-STAT signaling pathwayIFNA4;SOCS3B;NT5C3;RNF207B;Ifna11;PIAS4B;IFNE;IL2RGB;STAT2

IL29 has several biochemical functions, for example, cytokine activity, interleukin-28 receptor binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL29 itself. We selected most functions IL29 had, and list some proteins which have the same functions with IL29. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL25;IFNPHI2;GDF10;TNFSF9;IFNA12;Il1f9;LEFTY1;Ctf2;INHBB
interleukin-28 receptor binding
receptor bindingANGPTL2;GRP;NRG2B;GRIN2A;CNTFR;UFD1L;MIF;RAB8B;FZD1

IL29 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL29 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL29.

Ghoneum, M; Agrawal, S; et al. MGN-3/BIOBRAN ENHANCES GENERATION OF CYTOTOXIC CD8+T CELLS VIA UPREGULATION OF DEC-205 EXPRESSION ON DENDRITIC CELLS. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 27:523-530(2014).
Zhang, LL; Jilg, N; et al. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. JOURNAL OF HEPATOLOGY 55:289-298(2011).
WILLIAMS, RC; MALONE, CC; et al. IGG ANTI-F(AB')(2) ANTIBODIES FROM SLE PATIENTS REACT WITH IMMUNODOMINANT RESIDUES IN KAPPA-CDRS, BUT SHOW REDUCED C-KAPPA REGION REACTIVITY. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY 77:366-373(1995).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How should the dose of IL29 be determined? 08/01/2022

The dose of IL29 should be determined according to the specific disease and patient situation, and the most appropriate dose usually needs to be determined through clinical trials and individualized treatment.

What is the difference between IL29 and IL28? 06/02/2021

IL29 and IL28 are two similar interferons that are similar in structure and function, but with some minor differences such as receptor affinity and signaling pathways.

What are the advantages of IL29 compared with traditional drugs? 03/22/2021

IL29 is highly targeted and safe, and can stimulate the response of the own immune system, which has better therapeutic effect and fewer side effects than traditional drugs.

Does IL29 have antioxidant effects? 01/11/2021

At present, there are no clear studies to prove that IL29 has a direct antioxidant effect, but it may indirectly affect oxidative stress response by regulating immune system function.

Recombinant IL29 has potential in the treatment of which autoimmune diseases? 07/06/2020

IL29 has potential in the treatment of rheumatoid arthritis, hepatitis B, psoriasis and other autoimmune diseases.

Are there side effects of IL29? 04/18/2020

It may cause some mild side effects, such as fever, fatigue, headache, etc., but it is generally reversible, and serious side effects are rare.

Customer Reviews (3)

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Reviews
10/12/2022

    Storage conditions are very simple and can be stored for a long time.

    04/30/2022

      Anti-pollution ability is very strong, not easy to be polluted.

      09/12/2019

        Labeling effect is very good, can be fluorescent labeling and so on.

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